Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Bradley P, Sullivan"'
Autor:
Joshua O Sestak, Bradley P Sullivan, Sharadvi Thati, Laura Northrup, Brittany Hartwell, Lorena Antunez, M Laird Forrest, Charlotte M Vines, Teruna J Siahaan, Cory Berkland
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Autoimmune diseases such as multiple sclerosis (MS) are typified by the misrecognition of self-antigen and the clonal expansion of autoreactive T cells. Antigen-specific immunotherapies (antigen-SITs) have long been explored as a means to desensitize
Externí odkaz:
https://doaj.org/article/8ab9ff58c3e740d79df828ab13b98770
Autor:
John E. Froehlich, Nikita Joshi, Holly Cline-Fedewa, Anna V. Wojcicki, Matthew J. Flick, Brendan F. Johnson, Bradley P. Sullivan, Anna K. Kopec, James P. Luyendyk, Jessica L. Ray
Publikováno v:
Journal of Hepatology. 66:787-797
Background & Aims Acetaminophen (APAP)-induced liver injury is coupled with activation of the blood coagulation cascade and fibrin(ogen) accumulation within APAP-injured livers of experimental mice. We sought to define the role of fibrin(ogen) deposi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fca337eef15bbe158dc1dbc322632e08
https://doi.org/10.1016/j.jhep.2016.12.004
https://doi.org/10.1016/j.jhep.2016.12.004
Publikováno v:
ACS Macro Letters. 6:350-353
Chronic iron overload is a serious condition that develops as a consequence of long-term accumulation of iron, eventually overwhelming iron storage systems and causing oxidative stress and subsequent organ damage. Current pharmaceuticals used to trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c6cabcf975088264fa3b4280d1e9e3
https://doi.org/10.1021/acsmacrolett.6b00945
https://doi.org/10.1021/acsmacrolett.6b00945
Autor:
Melissa M. Pressnall, Cory Berkland, Stephanie N. Johnson, Chad J. Pickens, Bradley P. Sullivan, Martin A. Leon, Matthew A. Christopher, Sharadvi Thati
Publikováno v:
Mol Pharm
Multiple sclerosis represents the world's most common cause of neurological disability in young people and is attributed to a loss of immune tolerance toward proteins of the myelin sheath. Typical treatment options for MS patients involve immunomodul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e592de3d625738f0a07595abc55c45
https://pubmed.ncbi.nlm.nih.gov/31083955
https://pubmed.ncbi.nlm.nih.gov/31083955
Autor:
Bradley P. Sullivan, Aaron Smalter Hall, Joshua Sestak, Brittany L. Hartwell, Aaron Garza, Cory Berkland, Laura Northrup, David Swafford
Publikováno v:
Molecular Pharmaceutics. 13:330-343
Many current therapies for autoimmune diseases such as multiple sclerosis (MS) result in global immunosuppression, rendering insufficient efficacy with increased risk of adverse side effects. Multivalent soluble antigen arrays, nanomaterials presenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6cf25768a7b65b38000184a5c5b7202
https://doi.org/10.1021/acs.molpharmaceut.5b00825
https://doi.org/10.1021/acs.molpharmaceut.5b00825
Publikováno v:
Biomacromolecules. 16:2340-2346
Current antiobesity therapeutics are associated with side effects and/or poor long-term patient compliance, necessitating development of more efficacious and safer alternatives. Herein, we designed and engineered a new class of orally acting pharmace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d9b11f4a7bf26f3d0b4ce6f45b5dbf
https://doi.org/10.1021/acs.biomac.5b00560
https://doi.org/10.1021/acs.biomac.5b00560
Autor:
Sharadvi Thati, Joshua Sestak, Bradley P. Sullivan, Brittany L. Hartwell, Lorena R. Antunez, Cory Berkland
Publikováno v:
Journal of Pharmaceutical Sciences. 104:346-361
Continued development of multivalent nanomaterials has provided opportunities for the advancement of antigen-specific immunotherapies. New insights emerge when considering the backdrop of vaccine design, which has long employed multivalent presentati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7be9d61026c012c4d606ba9193c473
https://doi.org/10.1002/jps.24273
https://doi.org/10.1002/jps.24273
Publikováno v:
Molecular pharmaceutics. 14(1)
Current therapies to treat autoimmune diseases often result in side effects such as nonspecific immunosuppression. Therapies that can induce antigen-specific immune tolerance provide an opportunity to reverse autoimmunity and mitigate the risks assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c009ce040bfe97a427ccfaff131738e2
https://pubmed.ncbi.nlm.nih.gov/28043135
https://pubmed.ncbi.nlm.nih.gov/28043135
Autor:
Karen M. Kassel, James P. Luyendyk, Nikita Joshi, Bradley P. Sullivan, Anna K. Kopec, Matthew J. Flick, Keara Towery
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 351:288-297
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of obesity and metabolic syndrome. Robust coagulation cascade activation is common in obese patients with NAFLD. We identified a critical temporal relationship between thrombin gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a6f217277e398c8ba8c5345118e2a8
https://doi.org/10.1124/jpet.114.218545
https://doi.org/10.1124/jpet.114.218545
Autor:
Teruna J. Siahaan, Michael A. Thompson, Bradley P. Sullivan, Sharadvi Thati, Cory Berkland, Joshua Sestak, Christopher Kuehl
Publikováno v:
Journal of pharmaceutical sciences. 106(11)
Antigen-specific immunotherapy has been used to hyposensitize patients to allergens and offers an enticing approach for attenuating autoimmune diseases. Applying antigen-specific immunotherapy to mucosal surfaces such as the lungs may engage unique i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f7862762481fa9ab2bcf9034e98993
https://pubmed.ncbi.nlm.nih.gov/28625726
https://pubmed.ncbi.nlm.nih.gov/28625726