Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Bradley N. Martin"'
Autor:
Yanyun Du, Qianwen Peng, Du Cheng, Ting Pan, Wanwei Sun, Heping Wang, Xiaojian Ma, Ruirui He, Huazhi Zhang, Zhihui Cui, Xiong Feng, Zhiqiang Liu, Tianxin Zhao, Wenjun Hu, Lei Shen, Wenyang Jiang, Na Gao, Bradley N. Martin, Cun-Jin Zhang, Zhanguo Zhang, Chenhui Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Cancer cells producing ligands for the immune checkpoint molecules PD-1 and CTLA-4 is an important mechanism of tumour immune resistance. Here authors show that BTNL2 expression on cancer cells generates a dysfunctional tumour immune microenvironment
Externí odkaz:
https://doaj.org/article/bc2c48f5c4eb46b6b81e3b0918f911d1
Autor:
Jianwen Chen, Ruirui He, Wanwei Sun, Ru Gao, Qianwen Peng, Liwen Zhu, Yanyun Du, Xiaojian Ma, Xiaoli Guo, Huazhi Zhang, Chengcheng Tan, Junhan Wang, Wei Zhang, Xiufang Weng, Jianghong Man, Hermann Bauer, Qing K. Wang, Bradley N. Martin, Cun-Jin Zhang, Xiaoxia Li, Chenhui Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
TAGAP gene variants are linked to human autoimmunity. Here the authors identify TAGAP as a Dectin-1 and EphB2-binding protein mediating antifungal innate immune signaling and cytokine production, and demonstrate TAGAP in non-T cells promotes Th17 res
Externí odkaz:
https://doaj.org/article/69258493889b41e28feb66c907a43116
Autor:
Cun-Jin Zhang, Chenhui Wang, Meiling Jiang, Chunfang Gu, Jianxin Xiao, Xing Chen, Bradley N. Martin, Fangqiang Tang, Erin Yamamoto, Yibo Xian, Han Wang, Fengling Li, R. Balfour Sartor, Howard Smith, M. Elaine Husni, Fu-Dong Shi, Ji Gao, Julie Carman, Ashok Dongre, Susan C. McKarns, Ken Coppieters, Trine N. Jørgensen, Warren J. Leonard, Xiaoxia Li
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Adaptor for IL-17 receptors (Act1) is known to be crucial for IL-17-mediated immune responses. Here the authors show that Act1 also functions as a negative regulator of T and B cells by direct inhibition of STAT3.
Externí odkaz:
https://doaj.org/article/0e7548ce23cd448eb502abafb308eb2a
Autor:
Chenhui Wang, Cun-Jin Zhang, Bradley N. Martin, Katarzyna Bulek, Zizhen Kang, Junjie Zhao, Guanglin Bian, Julie A. Carman, Ji Gao, Ashok Dongre, Haibo Xue, Stephen D. Miller, Youcun Qian, Dolores Hambardzumyan, Tom Hamilton, Richard M. Ransohoff, Xiaoxia Li
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
NOTCH signalling stimulates oligodendrocyte progenitor cell proliferation but how this regulates demyelinating disease is unclear. Here, the authors show that an IL-17 adaptor protein, Act1, interacts with the C-terminal fragment of NOTCH1 (NICD) to
Externí odkaz:
https://doaj.org/article/6cf86ce31a16462e8d6947a6f2906f20
Autor:
Xiaojian Ma, Zhihui Cui, Yue-Ying Wang, Songfang Wu, Yanyun Du, Huazhi Zhang, Ruirui He, Liwen Zhu, Cun-Jin Zhang, Chenhui Wang, Bradley N. Martin, Qianwen Peng, Heping Wang, Ru Gao, Jianwen Chen, Huijun Hu, Wanwei Sun
Publikováno v:
The Journal of Immunology. 206:2353-2365
IL-17A plays an essential role in the pathogenesis of many autoimmune diseases, including psoriasis and multiple sclerosis. Act1 is a critical adaptor in the IL-17A signaling pathway. In this study, we report that an anti-sense long noncoding RNA, TR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4282bdabde09ab0b048172b4364d4618
https://doi.org/10.4049/jimmunol.2001223
https://doi.org/10.4049/jimmunol.2001223
Autor:
Wanwei Sun, Chenhui Wang, Cun-Jin Zhang, Yanyun Du, Ru Gao, Xiaojian Ma, Xinming Jia, Heping Wang, Bradley N. Martin, Junhan Wang, Jianwen Chen, Xiaoxia Li, Ruirui He, Zhihui Cui, Huijun Hu, Huazhi Zhang, Qianwen Peng
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Each year, the global mortality rates for fungal diseases now exceed those for malaria and breast cancer and are currently comparable to those for tuberculosis and HIV. The limited scope of currently available antifungal drugs is the maj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::845976b0d7ae7e8b17ac0923797bd49f
https://pubmed.ncbi.nlm.nih.gov/34301894
https://pubmed.ncbi.nlm.nih.gov/34301894
Autor:
Ruirui, He, Songfang, Wu, Ru, Gao, Jianwen, Chen, Qianwen, Peng, Huijun, Hu, Liwen, Zhu, Yanyun, Du, Wanwei, Sun, Xiaojian, Ma, Huazhi, Zhang, Zhihui, Cui, Heping, Wang, Bradley N, Martin, Yueying, Wang, Cun-Jin, Zhang, Chenhui, Wang
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 206(10)
IL-17A plays an essential role in the pathogenesis of many autoimmune diseases, including psoriasis and multiple sclerosis. Act1 is a critical adaptor in the IL-17A signaling pathway. In this study, we report that an anti-sense long noncoding RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3b6f7cb6e4c2eb1c238eda1fc01d93e5
https://pubmed.ncbi.nlm.nih.gov/33941656
https://pubmed.ncbi.nlm.nih.gov/33941656
Autor:
Ruirui He, Bradley N. Martin, Wei Yan, Yueguang Rong, Zhihui Cui, Yanyun Du, Ru Gao, Xiaoli Guo, Chenhui Wang, Xiaojian Ma, Du Cheng, Jianwen Chen, Wanwei Sun, Huazhi Zhang, Qianwen Peng
Publikováno v:
Autophagy
Although genome-wide association studies have identified the gene RNF186 encoding an E3 ubiquitin-protein ligase as conferring susceptibility to ulcerative colitis, the exact function of this protein remains unclear. In the present study, we demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f67588f28a352ba90e8a3c485125081
Autor:
R. Balfour Sartor, Chunfang Gu, Howard Smith, Warren J. Leonard, Ken Coppieters, Yibo Xian, Meiling Jiang, Bradley N. Martin, Susan C. McKarns, Cun Jin Zhang, Ashok Dongre, Chenhui Wang, Julie Carman, Xing Chen, Jianxin Xiao, Xiaoxia Li, M. Elaine Husni, Trine N. Jørgensen, Fu Dong Shi, Han Wang, Fangqiang Tang, Ji Gao, Erin Yamamoto, Fengling Li
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
Although Act1 (adaptor for IL-17 receptors) is necessary for IL-17-mediated inflammatory responses, Act1- (but not Il17ra-, Il17rc-, or Il17rb-) deficient mice develop spontaneous SLE- and Sjögren’s-like diseases. Here, we show that Act1 functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a48823b95b34a6dae3b3818caefb9b
http://link.springer.com/article/10.1038/s41467-018-04974-3
http://link.springer.com/article/10.1038/s41467-018-04974-3
Autor:
Christina Antonopoulos, Hana M. Russo, Caroline El Sanadi, Xiaoxia Li, George R. Dubyak, Bradley N. Martin, Edward S. Mocarski, William J. Kaiser
Publikováno v:
Journal of Biological Chemistry. 290:20167-20184
We recently described the induction of noncanonical IL-1β processing via caspase-8 recruited to ripoptosome signaling platforms in myeloid leukocytes. Here, we demonstrate that activated NLRP3·ASC inflammasomes recruit caspase-8 to drive IL-1β pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7da90071afa97c300038a43609dcaa
https://doi.org/10.1074/jbc.m115.652321
https://doi.org/10.1074/jbc.m115.652321