Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Bradley M. Kerr"'
Publikováno v:
Biopharmaceutics & Drug Disposition. 27:61-68
The effect of nelfinavir 1250 mg twice daily (b.i.d.) on the pharmacokinetics of methadone was determined in 14 HIV-negative methadone users. Design: The methadone dose (20–140 mg/day) was stabilized and fixed for at least 1 month before nelfinavir
Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection
Autor:
Lisa A Bauman, Eckart Schott, Bradley M. Kerr, Yves Horsmans, Tobias Mueller, Kevin R. Steffy, Averett Devron R, Simon P. Fletcher, Jean-Pierre Desager, Thomas Berg
Publikováno v:
Hepatology. 42:724-731
Immune-based therapy is the mainstay treatment for chronic hepatitis C virus (HCV) infection but causes multiple side effects and achieves durable viral clearance in only approximately 50% of patients. Most new investigational anti-HCV compounds are
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:392-397
A single-dose study and a multiple-dose study of the safety and pharmacokinetics of ruprintrivir, a new selective irreversible inhibitor of human rhinovirus 3C protease, were conducted with healthy adult volunteers. Both studies were double-blind, ra
Autor:
RenéH. Levy, Colleen J. Wurden, Kenneth E. Thummel, Deanna L. Kroetz, Frank J. Gonzalez, Susan M. Klein, Bradley M. Kerr
Publikováno v:
Biochemical Pharmacology. 47:1969-1979
A number of drugs inhibit the metabolism of carbamazepine catalyzed by cytochrome P450, sometimes resulting in carbamazepine intoxication. However, there is little information available concerning the identity of the specific isoforms of P450 respons
Autor:
Stephen E. Webber, Virginia N. Banh, Erik J. Rueden, Wei Li, Gregory J. Haley, Darian M. Bartkowski, Clark David Louis, Tingmin Wang, John S Ng, Mark R Herbert, Bradley M. Kerr, Leonid I Kirkovsky, Joseph R. Lennox, Alan X. Xiang, Averett Devron R, Simon P. Fletcher, Kevin R. Steffy, Lisa A Bauman
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 26(6-7)
ANA975, a 5-amino-3-beta -D-ribofuranosyl-3H-thiazolo[4,5-d]pyrimidin-2-one derivative, was synthesized in the search of an oral prodrug of isatoribine, a small molecule toll-like receptor 7 (TLR-7) agonist. Several strategies were studied to enable
Autor:
Yazdi K. Pithavala, Bradley M. Kerr, Michael N. Dudley, Kimberley A. Jackson, Geoffrey J. Yuen, Sara E. Rosenbaum
A population pharmacokinetic analysis was conducted on nelfinavir in patients infected with human immunodeficiency virus (HIV) who were enrolled in a phase III clinical trial. The data consisted of 509 plasma concentrations from 174 patients who rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf3c4abba34a8c9aa44f6cb15fc6bb1
https://europepmc.org/articles/PMC89969/
https://europepmc.org/articles/PMC89969/
Publikováno v:
Journal of Pharmaceutical Sciences. 80:812-814
The fraction of a dose of parent drug that is biotransformed to a specific metabolite is classically determined following separate administrations of parent drug and preformed metabolite: exercised in quantitating the fraction metabolized (fm) pharma
Autor:
Bradley M. Kerr, Lynne V. McFarland, Deanna L. Kroetz, Alan J. Wilensky, René H. Levy, Pierre Loiseau
Publikováno v:
Clinical pharmacology and therapeutics. 53(3)
An impairment or hereditary defect in microsomal epoxide hydrolase is considered a possible risk factor for drug and chemical toxicity. However, nothing is known about variability of in vivo epoxide hydrolase activity in humans. Our objectives were t
Publikováno v:
Epilepsia. 34(2)
Stiripentol (STP) was added to the antiepileptic drug (AED) regimen of 10 patients with uncontrolled atypical absence seizures (more than one seizure a day). Seven boys and three girls aged 6-16 years participated in the study. Concomitant AEDs inclu
Autor:
A. Craig Eddy, Jacques A. Tor, Bradley M. Kerr, C. Viteri, Juan M. Martinez-Lage, René H. Levy
Publikováno v:
Epilepsia. 32(2)
The inhibitory effect of stiripentol (STP) on disposition of carbamazepine (CBZ) and carbamazepine-10,11-epoxide (CBZE) was quantitated to establish CBZ dosage reduction guidelines for future clinical add-on efficacy trials of STP. In seven epileptic