Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Bradley M. Hover"'
Autor:
Sarah Charlop-Powers, Sean F. Brady, Jeanne Garbarino, Paula Y. Calle, Bradley M. Hover, Helen M. Forgione, Krista L. McGuire, Clara C. Pregitzer, Zachary Charlop-Powers, Jeffrey Maniko, Christophe Lemetre, Melinda A. Ternei
Publikováno v:
Proceedings of the National Academy of Sciences. 113:14811-14816
Numerous therapeutically relevant small molecules have been identified from the screening of natural products (NPs) produced by environmental bacteria. These discovery efforts have principally focused on culturing bacteria from natural environments r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e8985a4543f457dbf55925f24a2698d
https://doi.org/10.1073/pnas.1615581113
https://doi.org/10.1073/pnas.1615581113
Publikováno v:
Journal of Industrial Microbiology and Biotechnology. 43:129-141
Bacterial natural products have proven to be invaluable starting points in the development of many currently used therapeutic agents. Unfortunately, traditional culture-based methods for natural product discovery have been deemphasized by pharmaceuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d011d27d7d5ee72d09b3774e5731be
https://doi.org/10.1007/s10295-015-1706-6
https://doi.org/10.1007/s10295-015-1706-6
Publikováno v:
Biochemistry. 54:7229-7236
Molybdenum cofactor (Moco) is essential for all kingdoms of life, plays central roles in various biological processes, and must be biosynthesized de novo. During its biosynthesis, the characteristic pyranopterin ring is constructed by a complex rearr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909e5560d0318887c5d6db5bfce8d1dd
https://doi.org/10.1021/acs.biochem.5b00857
https://doi.org/10.1021/acs.biochem.5b00857
Autor:
Steven Park, Seong-Hwan Kim, Zachary Charlop-Powers, Jeremy G. Owen, Micah Katz, David S. Perlin, Andreia B. Estrela, Sean F. Brady, Melinda A. Ternei, Bradley M. Hover, Henrik Molina, Jeffrey Maniko
Publikováno v:
Nature microbiology. 3(4)
Despite the wide availability of antibiotics, infectious diseases remain a leading cause of death worldwide 1 . In the absence of new therapies, mortality rates due to untreatable infections are predicted to rise more than tenfold by 2050. Natural pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed4d9f9fa66cdd982ea956beec3ccd7
https://pubmed.ncbi.nlm.nih.gov/29588534
https://pubmed.ncbi.nlm.nih.gov/29588534
Publikováno v:
SLAS Discovery. 19:387-398
The identification of small molecules that positively modulate the mitochondrial respiratory function has broad applications in fundamental research, therapeutic target validation, and drug discovery. We present an approach in which primary screens f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49240662d4c64a7f9bd7962d83de1ea2
https://doi.org/10.1177/1087057113495295
https://doi.org/10.1177/1087057113495295
The molybdenum cofactor (Moco) is essential for all kingdoms of life, plays central roles in various biological processes, and must be biosynthesized de novo. During Moco biosynthesis, the characteristic pyranopterin ring is constructed by a complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42b9d2264addc4bdc02582324a9fab3
https://europepmc.org/articles/PMC4443348/
https://europepmc.org/articles/PMC4443348/
Autor:
Bradley M. Hover, Kenichi Yokoyama
The molybdenum cofactor (Moco) is an essential redox cofactor found in all kingdoms of life. Genetic mutations in the human Moco biosynthetic enzymes lead to a fatal metabolic disorder, Moco deficiency (MoCD). Greater than 50% of all human MoCD patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95a9f19e3244c76209d0188d0a87d5a
https://europepmc.org/articles/PMC4831585/
https://europepmc.org/articles/PMC4831585/
Publikováno v:
Journal of the American Chemical Society. 135(18)
The molybdenum cofactor (Moco) is a redox cofactor found in all kingdoms of life, and its biosynthesis is essential for survival of many organisms, including humans. The first step of Moco biosynthesis is a unique transformation of guanosine 5'-triph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5b1980ae831b84a8a26906dd19ba44
https://pubmed.ncbi.nlm.nih.gov/23627491
https://pubmed.ncbi.nlm.nih.gov/23627491