Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Bradley K. Hack"'
Autor:
Bradley K. Hack, Pottumarthi V. Prasad, Tipu S. Puri, Ujala Bokhary, Tammy Franklin, Anthony Chang, Muhammad E Haque, Liby Mathew
Publikováno v:
Journal of Magnetic Resonance Imaging. 39:835-841
Purpose To evaluate longitudinal changes in renal oxygenation and diffusion measurements in a model of reversible unilateral ureteral obstruction (rUUO) which has been shown to induce chronic renal functional deficits in a strain dependent way. C57BL
Autor:
Chang Xu, Michael T. Eadon, Patrick N. Cunningham, Bradley K. Hack, Jessy J. Alexander, M. Eileen Dolan
Publikováno v:
Physiological Genomics. 45:877-888
Colistin (polymixin E) is an antibiotic prescribed with resurging frequency for multidrug resistant gram negative bacterial infections. It is associated with nephrotoxicity in humans in up to 55% of cases. Little is known regarding genes involved in
Autor:
Sean Foxley, Bradley K. Hack, Richard J. Quigg, Jessy J. Alexander, Rebecca Rashmi Alexander, Marta Zamora, Brian B. Roman
Publikováno v:
Brain Research. 1504:85-96
Complement activation and inflammation are key disease features of systemic lupus erythematosus. Curcumin is an anti-inflammatory agent that inhibits the complement cascade. Therefore, we hypothesized that curcumin will be protective in CNS lupus. To
Publikováno v:
Journal of Neurochemistry. 119:1041-1051
Inflammation is a key factor in a number of neurodegenerative diseases including systemic lupus erythematosus (SLE). The complement system is an important mechanism in initiating and amplifying inflammation. Our recent studies demonstrate that C5a, a
Autor:
Bradley K. Hack, Jessy J. Alexander, Robert W. Finberg, Anthony Chang, Richard J. Quigg, Alexander Jacob, Mark Haas
Publikováno v:
The Journal of Immunology. 185:3759-3767
Complement receptor 1 (CR1) on human erythrocytes (Es) and complement factor H (CFH) on rodent platelets perform immune adherence, which is a function that allows the processing of immune complexes (ICs) bearing C3 by the mononuclear phagocyte system
Autor:
Bradley K. Hack, Richard J. Quigg, Eddie T. Chiang, Joe G.N. Garcia, Alexander Jacob, Jessy J. Alexander
Publikováno v:
The FASEB Journal. 24:1682-1688
The blood-brain barrier (BBB) is a crucial anatomic location in the brain. Its dysfunction complicates many neurodegenerative diseases, from acute conditions, such as sepsis, to chronic diseases, such as systemic lupus erythematosus (SLE). Several st
Autor:
Y. C. Li, Youli Wang, Richard J. Quigg, Bradley K. Hack, Jessy J. Alexander, C. W. Heilig, Jian Zhou, Mark Haas, Andrew W. Minto
Publikováno v:
Kidney International. 70:882-891
The db/db mouse develops features of type II diabetes mellitus as the result of impaired signaling through its abnormal leptin receptor. In spite of accurate metabolic features of diabetes, renal disease manifestations in these mice are not as severe
Autor:
V.M. Holers, Bradley K. Hack, Richard J. Quigg, Stephen J. Perkins, Joel M. Guthridge, M. Aslam
Publikováno v:
Journal of Molecular Biology. 329:525-550
Complement receptor-related gene/protein y (Crry) is a cell membrane-bound regulator of complement activation found in mouse and rat. Crry contains only short complement/consensus repeat (SCR) domains. X-ray and neutron scattering was performed on re
Autor:
Damian M. Kraus, V. Michael Holers, Lihua Bao, Mark Haas, Richard J. Quigg, Jonathan K. Rakstang, Bradley K. Hack
Publikováno v:
Journal of the American Society of Nephrology. 14:670-679
Complement receptor 1-related gene/protein y (Crry) in rodents is a potent membrane complement regulator that inhibits complement C3 activation by both classical and alternative pathways. To clarify the role of complement in lupus nephritis, MRL/lpr
Autor:
Guohui Ren, Richard J. Quigg, Bradley K. Hack, Mark Haas, Patrick N. Cunningham, Andrew W. Minto, Jessy J. Alexander
Publikováno v:
Clinical Immunology. 103:43-53
Thrombotic thrombocytopenic purpura (TTP) is an immunologically mediated disease characterized by thrombocytopenia, hemolytic anemia, and pathologic changes in various organs, including the kidney, which are secondary to widespread thromboses. Centra