Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Bradley K, Yoder"'
Autor:
Elizabeth J. Wilk, Timothy C. Howton, Jennifer L. Fisher, Vishal H. Oza, Ryan T. Brownlee, Kasi C. McPherson, Hannah L. Cleary, Bradley K. Yoder, James F. George, Michal Mrug, Brittany N. Lasseigne
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-21 (2023)
Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is one of the most prevalent monogenic human diseases. It is mostly caused by pathogenic variants in PKD1 or PKD2 genes that encode interacting transmembrane proteins polycystin
Externí odkaz:
https://doaj.org/article/a29d831d0f624c96a1f2239ed4a5233e
Autor:
Zhang Li, Kurt A. Zimmerman, Sreelakshmi Cherakara, Phillip H. Chumley, James F. Collawn, Jun Wang, Courtney J. Haycraft, Cheng J. Song, Teresa Chacana, Reagan S. Andersen, Mandy J. Croyle, Ernald J. Aloria, Raksha P. Hombal, Isis N. Thomas, Hanan Chweih, Kristin L. Simanyi, James F. George, John M. Parant, Michal Mrug, Bradley K. Yoder
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 1 (2023)
Externí odkaz:
https://doaj.org/article/d33111929bb3477fae3f2ddadac69a61
Autor:
Jun Wang, Holly R. Thomas, Robert G. Thompson, Stephanie C. Waldrep, Joseph Fogerty, Ping Song, Zhang Li, Yongjie Ma, Peu Santra, Jonathan D. Hoover, Nan Cher Yeo, Iain A. Drummond, Bradley K. Yoder, Jeffrey D. Amack, Brian Perkins, John M. Parant
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 12 (2022)
Externí odkaz:
https://doaj.org/article/5728cfeb2b524af68015cb523dbf9266
Autor:
Matthew D. Cheung, Elise N. Erman, Kyle H. Moore, Jeremie M.P. Lever, Zhang Li, Jennifer R. LaFontaine, Gelare Ghajar-Rahimi, Shanrun Liu, Zhengqin Yang, Rafay Karim, Bradley K. Yoder, Anupam Agarwal, James F. George
Publikováno v:
JCI Insight, Vol 7, Iss 20 (2022)
The kidney contains a population of resident macrophages from birth that expands as it grows and forms a contiguous network throughout the tissue. Kidney-resident macrophages (KRMs) are important in homeostasis and the response to acute kidney injury
Externí odkaz:
https://doaj.org/article/b97df05f74f3447c9bc4cd10ffa3410d
Autor:
Melissa R. Bentley-Ford, Reagan S. Andersen, Mandy J. Croyle, Courtney J. Haycraft, Kelsey R. Clearman, Jeremy B. Foote, Jeremy F. Reiter, Bradley K. Yoder
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Atxn10 is a gene known for its role in cytokinesis and is associated with spinocerebellar ataxia (SCA10), a slowly progressing cerebellar syndrome caused by an intragenic pentanucleotide repeat expansion. Atxn10 is also implicated in the ciliopathy s
Externí odkaz:
https://doaj.org/article/9d7d5542e32b4071b4aa9da8b86dd96c
Autor:
Mary Claire Doss, Sean Mullen, Ronald Roye, Juling Zhou, Phillip Chumley, Elias Mrug, Darren P. Wallace, Feng Qian, Peter C. Harris, Bradley K. Yoder, Harrison Kim, Michal Mrug
Publikováno v:
American Journal of Physiology-Renal Physiology. 324:F423-F430
Total kidney volume (TKV) is a valuable readout in preclinical studies for autosomal dominant and autosomal recessive polycystic kidney diseases (ADPKD and ARPKD). Since conventional TKV assessment by manual contouring of kidney areas in all images i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbb4aca665b03f77422297186a9e127f
https://doi.org/10.1152/ajprenal.00295.2022
https://doi.org/10.1152/ajprenal.00295.2022
Autor:
Cheng J. Song, Zhang Li, Ummey Khalecha Bintha Ahmed, Sarah J. Bland, Alex Yashchenko, Shanrun Liu, Ernald J. Aloria, Jeremie M. Lever, Nancy M. Gonzalez, Marisa A. Bickel, Cory B. Giles, Constantin Georgescu, Jonathan D. Wren, Mark L. Lang, Etty N. Benveniste, Laurie E. Harrington, Leo Tsiokas, James F. George, Kenneth L. Jones, David K. Crossman, Anupam Agarwal, Michal Mrug, Bradley K. Yoder, Katharina Hopp, Kurt A. Zimmerman
Publikováno v:
J Am Soc Nephrol
BACKGROUND: Inducible disruption of cilia-related genes in adult mice results in slowly progressive cystic disease, which can be greatly accelerated by renal injury. METHODS: To identify in an unbiased manner modifier cells that may be influencing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b68546a95ed560353a481fa4245dbfd
https://doi.org/10.1681/asn.2021030278
https://doi.org/10.1681/asn.2021030278
Autor:
Michal Mrug, Cheng Jack Song, Bradley K. Yoder, Sarah J. Bland, Zhang Li, Alex Yashchenko, Kurt A. Zimmerman, David K. Crossman, Juling Zhou, Ernald Jules G. Aloria
Publikováno v:
Lab Invest
Hepatorenal fibrocystic disease (HRFCD) is a genetically inherited disorder related to primary cilia dysfunction in which patients display varying levels of fibrosis, bile duct expansion, and inflammation. In mouse models of HRFCD, the phenotype is g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e204a107cde0ea82b86c45c338cf69
https://doi.org/10.1038/s41374-021-00627-0
https://doi.org/10.1038/s41374-021-00627-0
Autor:
Zhang Li, Zhengqin Yang, Jeremie M. Lever, Kurt A. Zimmerman, Bradley K. Yoder, Mandy J. Croyle, James F. George, Anupam Agarwal
Publikováno v:
Am J Physiol Renal Physiol
Kidney resident macrophages (KRMs) are involved in maintaining renal homeostasis and in controlling the pathological outcome of acute kidney injury and cystic kidney disease in mice. In adult mice, KRMs maintain their population through self-renewal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7542d2673072d2e63ae160489016fb80
https://doi.org/10.1152/ajprenal.00129.2021
https://doi.org/10.1152/ajprenal.00129.2021
Autor:
Kurt A. Zimmerman, Zhang Li, Michal Mrug, Ernald Jules G. Aloria, Cheng Jack Song, Bradley K. Yoder, Mandy J. Croyle
Publikováno v:
Kidney360. 2:989-995
Key Points Ly6chi infiltrating macrophage numbers are increased in injured, conditional Ift88 mice, compared with controls. Loss of Ly6chi infiltrating macrophages slows injury-accelerated cystic disease. Ly6chi infiltrating macrophages drive cystic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c320092f563b39189058d682c41d367d
https://doi.org/10.34067/kid.0000882021
https://doi.org/10.34067/kid.0000882021