Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Bradley J. Stevenson"'
Publikováno v:
Protein Engineering, Design and Selection. 35
Steroid sulfate esters are important metabolites for anti-doping efforts in sports, pathology and research. Analysis of these metabolites is facilitated by hydrolysis using either acid or enzymatic catalysis. Although enzymatic hydrolysis is preferre
Publikováno v:
Protein Engineering, Design and Selection. 32:129-143
In the accompanying paper, we described evolving a lipase to the point where variants were soluble, stable and capable of degrading C8 TAG and C8 esters. These variants were tested for their ability to survive in an environment that might be encounte
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 3, p e1595 (2012)
BACKGROUND: Pyrethroids are increasingly used to block the transmission of diseases spread by Aedes aegypti such as dengue and yellow fever. However, insecticide resistance poses a serious threat, thus there is an urgent need to identify the genes an
Externí odkaz:
https://doaj.org/article/c00d6e17c97143d8bdedbc93bf850cf0
Autor:
Dimanthi R. Uduwela, Malcolm D. McLeod, Anna Pabis, Bradley J. Stevenson, Shina Caroline Lynn Kamerlin
Publikováno v:
ACS Catalysis. 8:8902-8914
Steroidal sulfate esters play a central role in many physiological processes. They serve as the reservoir for endogenous sex hormones and form a significant fraction of the steroid metabolite pool. The analysis of steroid sulfates is thus essential i
Autor:
Pie Müller, Emma Warr, Bradley J Stevenson, Patricia M Pignatelli, John C Morgan, Andrew Steven, Alexander E Yawson, Sara N Mitchell, Hilary Ranson, Janet Hemingway, Mark J I Paine, Martin J Donnelly
Publikováno v:
PLoS Genetics, Vol 4, Iss 11, p e1000286 (2008)
Insects exposed to pesticides undergo strong natural selection and have developed various adaptive mechanisms to survive. Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is receiving increasing attention because it threa
Externí odkaz:
https://doaj.org/article/fccb1cc9dea44363a0be828d5a3770a5
Autor:
Valentin Pop, Mario Thevis, Bradley J. Stevenson, Thomas Piper, Dimanthi R. Uduwela, Wilhelm Schänzer, Malcolm D. McLeod, Marlen Putz
Publikováno v:
Drug Testing and Analysis. 9:1695-1703
In the course of investigations into the metabolism of testosterone (T) by means of deuterated T and hydrogen isotope ratio mass spectrometry, a pronounced influence of the oral administration of T on sulfoconjugated steroid metabolites was observed.
Autor:
Mark J. I. Paine, Cristina Yunta, Szilárd Nász, Kay Hemmings, Lizette L. Koekemoer, Bradley J. Stevenson, Michael W. Voice, Tonderi Matambo, Patricia Pignatelli
Publikováno v:
Pesticide biochemistry and physiology. 161
Extensive use of pyrethroids for malaria control in Africa has led to widespread pyrethroid resistance in the two major African vectors of malaria An. gambiae and An. funestus. This is often associated with constitutively elevated levels of cytochrom
Autor:
Paul Ma, Adam Cawley, Bradley J. Stevenson, Kunkun Li, David L. Ollis, Christopher C. Waller, Malcolm D. McLeod
Publikováno v:
Drug Testing and Analysis. 7:903-911
The hydrolysis of sulfate ester conjugates is frequently required prior to analysis for a range of analytical techniques including gas chromatography-mass spectrometry (GC-MS). Sulfate hydrolysis may be achieved with commercial crude arylsulfatase en
Autor:
Adam Cawley, Bradley J. Stevenson, Han Ling Fam, Malcolm D. McLeod, Sumudu A. Weththasinghe, Christopher C. Waller
Publikováno v:
Drug testing and analysis. 10(2)
In vitro technologies provide the capacity to study drug metabolism where in vivo studies are precluded due to ethical or financial constraints. The metabolites generated by in vitro studies can assist anti-doping laboratories to develop protocols fo
Autor:
Lijun Cai, Yonglin Ren, Michelle Michie, Alisha Anderson, Bradley J. Stevenson, Wei Xu, Sylwester Chyb, Amalia Z. Berna, C. Faucher
Publikováno v:
Journal of economic entomology. 110(3)
The red flour beetle, Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae), is a worldwide pest of stored grains. Using "Y"-tube olfactometry we studied the response of T. castaneum to odors from simulated wheat infestations containing conspecifi