Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Bradley J Wagstaff"'
Autor:
Bradley J Wagstaff, Dale J Hedges, Rebecca S Derbes, Rebeca Campos Sanchez, Francesca Chiaromonte, Kateryna D Makova, Astrid M Roy-Engel
Publikováno v:
PLoS Genetics, Vol 8, Iss 8, p e1002842 (2012)
Alu elements are trans-mobilized by the autonomous non-LTR retroelement, LINE-1 (L1). Alu-induced insertion mutagenesis contributes to about 0.1% human genetic disease and is responsible for the majority of the documented instances of human retroelem
Externí odkaz:
https://doaj.org/article/a3d6b4d5493242569bc41f608ba1e3b4
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19672 (2011)
LINE-1 (L1) retroelements emerged in mammalian genomes over 80 million years ago with a few dominant subfamilies amplifying over discrete time periods that led to distinct human and mouse L1 lineages. We evaluated the functional conservation of L1 se
Externí odkaz:
https://doaj.org/article/d4d972c4b0264f20b648c75f48379255
Publikováno v:
PLoS Genetics, Vol 5, Iss 4, p e1000458 (2009)
Mobile elements comprise close to one half of the mass of the human genome. Only LINE-1 (L1), an autonomous non-Long Terminal Repeat (LTR) retrotransposon, and its non-autonomous partners-such as the retropseudogenes, SVA, and the SINE, Alu-are curre
Externí odkaz:
https://doaj.org/article/ebaa5206f44746c68692e3529a2c6137
Autor:
Victoria P. Belancio, Catherine M. Ade, Rebecca S. Derbes, Sara B. Linker, Zoltán Ivics, Dawn deHaro, Bradley J. Wagstaff, Travis B. White, Astrid M. Roy-Engel
Publikováno v:
Gene. 642:188-198
DNA binding domains (DBDs) have been used with great success to impart targeting capabilities to a variety of proteins creating highly useful genomic tools. We evaluated the ability of five types of DBDs and strategies (AAV Rep proteins, Cre, TAL eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efce7d23abd0f088a39edb6958ad62e8
https://doi.org/10.1016/j.gene.2017.11.033
https://doi.org/10.1016/j.gene.2017.11.033
Mobile elements have significantly impacted genome structure of most organisms. The continued activity of the mobile element, LINE-1 (L1), through time has contributed to the accumulation of over half a million L1 copies in the human genome. Most cop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2406803f75fbae45470dc4933c96338
https://europepmc.org/articles/PMC6136441/
https://europepmc.org/articles/PMC6136441/
Autor:
Rebecca S. Derbes, Astrid M. Roy-Engel, Bradley J. Wagstaff, Emily N. Kroutter, Victoria P. Belancio
Publikováno v:
Molecular Biology and Evolution
Non-long terminal repeat retroelements continue to impact the human genome through cis-activity of long interspersed element-1 (LINE-1 or L1) and trans-mobilization of Alu. Current activity is dominated by modern subfamilies of these elements, leavin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f306fbb0f040f5541e4600e136bb63c
http://europepmc.org/articles/PMC3525338
http://europepmc.org/articles/PMC3525338
Autor:
David J. Begun, Bradley J. Wagstaff
Publikováno v:
Molecular Biology and Evolution. 22:818-832
Male accessory gland protein genes (Acps) evolve rapidly in the melanogaster species subgroup of Drosophila. However, conservation of Acps in more diverged lineages is poorly understood. We used comparisons of the D. melanogaster and D. pseudoobscura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2968feb97164b33ff58a60d0f42bfdd8
https://doi.org/10.1093/molbev/msi067
https://doi.org/10.1093/molbev/msi067
Publikováno v:
The Biological Bulletin. 196:63-69
Colonies of the ascidian Botryllus schlosseri (a cyclical hermaphrodite) exhibit extreme variability in egg production, and there is a large genetic component to this phenotypic variation. Therefore, the developmental bases of variation among differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f287d93465f6549551c5e5d3acbcea65
https://doi.org/10.2307/1543168
https://doi.org/10.2307/1543168
Autor:
Rebecca S. Derbes, Bradley J. Wagstaff, Francesca Chiaromonte, Dale J. Hedges, Rebeca Campos Sanchez, Astrid M. Roy-Engel, Kateryna D. Makova
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 8, Iss 8, p e1002842 (2012)
PLoS Genetics, Vol 8, Iss 8, p e1002842 (2012)
Alu elements are trans-mobilized by the autonomous non-LTR retroelement, LINE-1 (L1). Alu-induced insertion mutagenesis contributes to about 0.1% human genetic disease and is responsible for the majority of the documented instances of human retroelem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf385edcf8e0a58cd9ba06ce4966619
http://hdl.handle.net/11382/513234
http://hdl.handle.net/11382/513234
Publikováno v:
Gene. 419(1-2)
Retroelements have contributed over one third of the human genome mass. The currently active LINE-1 (L1) codes for two proteins (ORF1p and ORF2p), both strictly required for retrotransposition. In contrast, the non-coding parasitic SINE (Alu) only ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::431288d9e752ab3c85dbac4df9da1625
https://pubmed.ncbi.nlm.nih.gov/18534786
https://pubmed.ncbi.nlm.nih.gov/18534786