Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Bradley J Backes"'
Autor:
Maike Thamsen, Rajarshi Ghosh, Vincent C Auyeung, Alexis Brumwell, Harold A Chapman, Bradley J Backes, Gayani Perara, Dustin J Maly, Dean Sheppard, Feroz R Papa
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0209824 (2019)
Endoplasmic reticulum stress (ER stress) has been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a disease of progressive fibrosis and respiratory failure. ER stress activates a signaling pathway called the unfolded protein re
Externí odkaz:
https://doaj.org/article/72a21c8a3c184effb4aa0c1bf69d7717
Autor:
Scott A. Oakes, Feroz R. Papa, Bradley J. Backes, Dustin J. Maly, Grace E. Kim, Annie Hiniker, Rachel E. Warren, Rosa Meza-Acevedo, Micah J. Gliedt, Justin Peng, Rajarshi Ghosh, Maike Thamsen, Jenny Y. Qi, Paul C. Moore
KIRA8 and GSK-PKI induce distinct apoptotic markers in INS1 tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f01540573145c2470ed78f2d3839477
https://doi.org/10.1158/0008-5472.22422192.v1
https://doi.org/10.1158/0008-5472.22422192.v1
Autor:
Scott A. Oakes, Feroz R. Papa, Bradley J. Backes, Dustin J. Maly, Grace E. Kim, Annie Hiniker, Rachel E. Warren, Rosa Meza-Acevedo, Micah J. Gliedt, Justin Peng, Rajarshi Ghosh, Maike Thamsen, Jenny Y. Qi, Paul C. Moore
CRISPR/Cas9 guide oligos, genotyping/sequencing primers, and q-PCR primers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ba83b902509eaa50fdf68b5fdaef36
https://doi.org/10.1158/0008-5472.22422183
https://doi.org/10.1158/0008-5472.22422183
Autor:
Scott A. Oakes, Feroz R. Papa, Bradley J. Backes, Dustin J. Maly, Grace E. Kim, Annie Hiniker, Rachel E. Warren, Rosa Meza-Acevedo, Micah J. Gliedt, Justin Peng, Rajarshi Ghosh, Maike Thamsen, Jenny Y. Qi, Paul C. Moore
Master regulators of the unfolded protein response (UPR), IRE1α and PERK, promote adaptation or apoptosis depending on the level of endoplasmic reticulum (ER) stress. Although the UPR is activated in many cancers, its effects on tumor growth remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::679562d6e2c3b557add888ab01883cce
https://doi.org/10.1158/0008-5472.c.6511146.v1
https://doi.org/10.1158/0008-5472.c.6511146.v1
Autor:
Vincent C. Auyeung, Michael S. Downey, Maike Thamsen, Talia A. Wenger, Bradley J. Backes, Dean Sheppard, Feroz R. Papa
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
After lung injury, damage-associated transient progenitors (DATPs) emerge, representing a transitional state between injured epithelial cells and newly regenerated alveoli. DATPs express profibrotic genes, suggesting that they might promote idiopathi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6ca567b10dbdb443a9e6d5321aceae
https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5244
https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5244
Autor:
Rajarshi Ghosh, B. Gayani K. Perera, Feroz R. Papa, Venkata Narayana Vidadala, Vincent C. Auyeung, Zachary E. Potter, Alina Olivier, Julie Zikherman, Jae-Hong Kim, Dustin J. Maly, James L. Mueller, Bradley J. Backes, Hannah C. Feldman
Publikováno v:
Nature chemical biology, vol 17, iss 11
The unfolded protein response (UPR) homeostatically matches endoplasmic reticulum (ER) protein-folding capacity to cellular secretory needs. However, under high or chronic ER stress, the UPR triggers apoptosis. This cell fate dichotomy is promoted by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0723837b01d50cfdb07ac11767477d32
https://escholarship.org/uc/item/68f3g7m2
https://escholarship.org/uc/item/68f3g7m2
Autor:
Alexis Brumwell, Harold A. Chapman, Vincent C. Auyeung, Feroz R. Papa, Maike Thamsen, Michael S. Downey, Dean Sheppard, Bradley J. Backes, Jaymin J. Kathiriya, Talia A. Wenger
Idiopathic pulmonary fibrosis (IPF) is a disease of progressive interstitial fibrosis, which leads to severe debilitation, respiratory failure, and death. In IPF, environmental exposures interact with genetic risk factors to engender critical patho-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aad9c1f7f0f13d4146f65458325184f8
https://doi.org/10.1101/2021.09.16.460705
https://doi.org/10.1101/2021.09.16.460705
Autor:
Yusuke Yamashita, Hiroyuki Mishima, Takashi Sonoki, Shohei Kishimoto, Hiroki Hosoi, Shinobu Tamura, Bradley J. Backes, Feroz R. Papa, Tatsuya Ishibashi, Akira Kinoshita, Hiroshi Kobata, Shuhei Morita, Koh-ichiro Yoshiura
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6314, p 6314 (2020)
Volume 21
Issue 17
International Journal of Molecular Sciences, Vol 21, Iss 6314, p 6314 (2020)
Volume 21
Issue 17
Background: Inositol-requiring enzyme 1&alpha
(IRE1&alpha
), along with protein kinase R-like endoplasmic reticulum kinase (PERK), is a principal regulator of the unfolded protein response (UPR). Recently, the &lsquo
mono&rsquo
sp
(IRE1&alpha
), along with protein kinase R-like endoplasmic reticulum kinase (PERK), is a principal regulator of the unfolded protein response (UPR). Recently, the &lsquo
mono&rsquo
sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5c0c084077e28d56297294a9998173
http://europepmc.org/articles/PMC7504392
http://europepmc.org/articles/PMC7504392
Autor:
Walter L. Eckalbar, Kojiro Mukai, Christopher S. Law, Zimu Deng, Frances O. Ho, Anthony K. Shum, Tomohiko Taguchi, Zhenlu Chong, Tereza Martinu, Bradley J. Backes
Publikováno v:
The Journal of Experimental Medicine
A defect in COPI transport due to mutant COPA causes multimerization of STING on the Golgi and type I interferon–driven immune dysregulation in mice. Small-molecule inhibition of STING activation is a new molecular target for treating COPA syndrome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226827923aed4bba371b7923bf5273da
https://doi.org/10.1101/2020.05.20.106500
https://doi.org/10.1101/2020.05.20.106500
Autor:
Vincent C. Auyeung, Bradley J. Backes, N.R. Bhakta, Dustin J. Maly, Prescott G. Woodruff, Feroz R. Papa, Dean Sheppard
Publikováno v:
B32. ASTHMA: MECHANISMS OF DISEASE I.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c92d484e757df64f6e3898f73684210
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2906
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2906