Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Bradley J, Stith"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 128, Iss 4, Pp 193-201 (2015)
Neural tissue exposure to valproic acid (VPA) increases several pro-survival phospho-proteins that can be used as biomarkers for indicating a beneficial drug response (pAktSer473, pGSK3βSer9, pErk1/2Thr202/Tyr204). Unfortunately, targeting VPA to ne
Externí odkaz:
https://doaj.org/article/a19cb5ce2a7a4fa59001b41d61bec4be
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 11, Pp 2365-2378 (2008)
Critical developmental periods, such as fertilization, involve metabolic activation, membrane fusion events such as sperm-egg or plasma membrane-cortical granule merger, and production and hydrolysis of phospholipids. However, there has been no large
Externí odkaz:
https://doaj.org/article/7d83e086baf742d7b90aeb788060f509
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 4, Pp 854-858 (2003)
Phosphatidic acid (PA) and lysophosphatidic acid (LPA) are lipids that regulate cellular processes. PA stimulates kinases and may play a role in exocytosis and membrane fusion. LPA can induce cell proliferation, platelet aggregation, and microfilamen
Externí odkaz:
https://doaj.org/article/2bc3068ddd6943799dc0d7b32673f33e
Autor:
Colby P. Fees, Bradley J. Stith
Publikováno v:
Developmental Biology. 448:59-68
During Xenopus fertilization, the initial intracellular calcium ((Ca2+)i) release at the sperm-egg binding site (hot spot) has not been described without the use of inhibitors, nor related to underlying ER structure. Without inhibitors, we now report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0cc738d7052d43f58df15732799e1c1
https://doi.org/10.1016/j.ydbio.2019.01.004
https://doi.org/10.1016/j.ydbio.2019.01.004
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 9, Pp 1448-1454 (2000)
Lipid signaling has become a major research area of cell biology and there is a need for methods that accurately and easily measure substrates and products of lipases involved in cell signaling. In this report, we provide new methodology for separati
Externí odkaz:
https://doaj.org/article/e8ed730040ad4513ac61628e0bdaa8d1
Autor:
Colby P, Fees, Bradley J, Stith
Publikováno v:
Developmental biology. 448(1)
During Xenopus fertilization, the initial intracellular calcium ((Ca(2+))(i)) release at the sperm-egg binding site (hot spot) has not been described without the use of inhibitors, nor related to underlying ER structure. Without inhibitors, we now re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31a52ebff9991d5d049cac00b3193e25
https://pubmed.ncbi.nlm.nih.gov/30641042
https://pubmed.ncbi.nlm.nih.gov/30641042
Autor:
Bradley J. Stith
Publikováno v:
Developmental Biology. 401:188-205
This review emphasizes how lipids regulate membrane fusion and the proteins involved in three developmental stages: oocyte maturation to the fertilizable egg, fertilization and during first cleavage. Decades of work show that phosphatidic acid (PA) r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08145097697d4e84f8dace6ca21fe82e
https://doi.org/10.1016/j.ydbio.2015.02.020
https://doi.org/10.1016/j.ydbio.2015.02.020
Publikováno v:
Pharmacology Biochemistry and Behavior. 103:237-244
Valproic acid (VPA) is the most widely prescribed antiepileptic drug due to its ability to treat a broad spectrum of seizure types. However, potential complications of this drug include anticonvulsant polytherapy metabolism, organ toxicity and terato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b559c9b4c256cc500dc62db86bf987f7
https://doi.org/10.1016/j.pbb.2012.08.023
https://doi.org/10.1016/j.pbb.2012.08.023
Publikováno v:
Seminars in Cell & Developmental Biology. 17:285-292
At fertilization, eggs unite with sperm to initiate developmental programs that give rise to development of the embryo. Defining the molecular mechanism of this fundamental process at the beginning of life has been a key question in cell and developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f107eb13afe128c4b07ca28a3b89c5dd
https://doi.org/10.1016/j.semcdb.2006.02.008
https://doi.org/10.1016/j.semcdb.2006.02.008
Publikováno v:
Biochemical Pharmacology. 67:2081-2091
Metformin is a commonly used anti-diabetic but whether its mechanism involves action on the insulin receptor or on downstream events is still controversial. With a time course that was slow compared with insulin action, metformin increased tyrosine p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f8425a7a00818db674d7047d639201
https://doi.org/10.1016/j.bcp.2004.02.016
https://doi.org/10.1016/j.bcp.2004.02.016