Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Bradley J, Molyneaux"'
Autor:
Ruchit V. Patel, Lilin Tong, Bradley J. Molyneaux, Nirav J. Patel, Mohammed A. Aziz-Sultan, Amar Dhand, Wenya Linda Bi
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
IntroductionIntracranial hemorrhages present across a spectrum of clinical phenotypes, with many patients transferred across hospitals to access higher levels of neurocritical care. We sought to characterize patient dispositions following intracrania
Externí odkaz:
https://doaj.org/article/84012d0378b145c4ad863281bf9140ac
Autor:
Keiko A. Fukuda, Kavit Shah, Cynthia Kenmuir, Derrick Barnagian, Baraa Nawash, Shashvat Desai, Marcelo Rocha, Matthew Starr, Eileen Roach, Stephanie Henry, Bradley J. Molyneaux, Ashutosh P. Jadhav
Publikováno v:
Stroke: Vascular and Interventional Neurology, Vol 4, Iss 3 (2024)
Background Our health care systems continue to face significant strain due to chronically taxed intensive care resources. A subgroup of patients following thrombolytic stroke may not require prolonged intensive monitoring, alleviating some burden. He
Externí odkaz:
https://doaj.org/article/d8737377a84d4215985b154110a4c5f2
Autor:
Jinwei Zhang, Mohammad Iqbal H. Bhuiyan, Ting Zhang, Jason K. Karimy, Zhijuan Wu, Victoria M. Fiesler, Jingfang Zhang, Huachen Huang, Md Nabiul Hasan, Anna E. Skrzypiec, Mariusz Mucha, Daniel Duran, Wei Huang, Robert Pawlak, Lesley M. Foley, T. Kevin Hitchens, Margaret B. Minnigh, Samuel M. Poloyac, Seth L. Alper, Bradley J. Molyneaux, Andrew J. Trevelyan, Kristopher T. Kahle, Dandan Sun, Xianming Deng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
SPAK kinase is a master regulator of cation-Cl− cotransporters. Here the authors describe a new SPAK inhibitor with robust protective effects in rodent hydrocephalous and ischemic stroke models.
Externí odkaz:
https://doaj.org/article/3b3910c818a141759af3688133b30605
Publikováno v:
The Neurohospitalist. 13:169-172
Cenobamate is an effective new adjunctive antiseizure medication (ASM) for treatment resistant focal epilepsy. It has broad spectrum anticonvulsant activity and may be a useful medication for super refractory status epilepticus (SRSE), but has not ye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fce69a7508240f34bed68c6959af1be
https://doi.org/10.1177/19418744221147083
https://doi.org/10.1177/19418744221147083
Autor:
Keiko A Fukuda, Kavit Shah, Cynthia Kenmuir, Derrick Barnagian, Baraa Nawash, Mackenzie Nelson, Shashvat Desai, Marcelo Rocha, Matthew Starr, Eileen Roach, Stephanie Henry, Bradley J Molyneaux, Ashutosh P Jadhav
IntroductionOur health care systems continue to face significant strain due to chronically taxed intensive care resources. A subgroup of post-thrombolytic stroke patients may not require prolonged intensive monitoring, alleviating some burden. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e9139125d2a66ea629d287cb0634588
https://doi.org/10.1101/2023.03.27.23287831
https://doi.org/10.1101/2023.03.27.23287831
Autor:
Mohammad Iqbal H. Bhuiyan, Cullen B. Young, Israt Jahan, Md Nabiul Hasan, Sydney Fischer, Nur Farah Meor Azlan, Mingjun Liu, Ansuman Chattopadhyay, Huachen Huang, Kristopher T. Kahle, Jinwei Zhang, Samuel M. Poloyac, Bradley J. Molyneaux, Adam C. Straub, Xianming Deng, Delphine Gomez, Dandan Sun
Publikováno v:
Stroke
Background: Worsened stroke outcomes with hypertension comorbidity are insensitive to blood pressure-lowering therapies. In an experimental stroke model with comorbid hypertension, we investigated causal roles of ang II (angiotensin II)–mediated st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55550fbefbd3eb67eb23abdd0eb66361
https://doi.org/10.1161/strokeaha.121.038351
https://doi.org/10.1161/strokeaha.121.038351
Autor:
Noriyuki Kishi, Jessica L. MacDonald, Julia Ye, Bradley J. Molyneaux, Eiman Azim, Jeffrey D. Macklis
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Rett syndrome is a neurodevelopmental disorder caused by mutations in Mecp2. Here the authors show that Mecp2 loss-of-function leads to upregulation of the NF-κB pathway, and that reducing NF-κB signalling ameliorates phenotypes of Mecp2-null mice,
Externí odkaz:
https://doaj.org/article/573f6b6aaf6a4976a621f82c8007141a
Publikováno v:
Practical Neurology. :pn-2023
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a318011181ecefe1cff08fce768e7956
https://doi.org/10.1136/pn-2023-003732
https://doi.org/10.1136/pn-2023-003732
Autor:
Kevin N Sheth, W Taylor Kimberly, Gregory W Albers, Bruce C Campbell, Charlotte Cordonnier, H E Hinson, Bradley J Molyneaux, Raul G Nogueira, Jeffrey L Saver, Thorsten Steiner, Kazunori Toyoda, Max Wintermark, Randa Hareedy, Michael Wald, Ray Zhang, Nikolaos K Ziogas, Marco Rizzo
Publikováno v:
Stroke. 53
Objective: To present baseline data from initially enrolled participants in CHARM, a Phase 3 study evaluating whether intravenous (IV) glibenclamide (BIIB093) improves functional outcomes at 90 days in individuals with large hemispheric infarction (L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e23adc9a169b8cb2bf547a5f6d1e6022
https://doi.org/10.1161/str.53.suppl_1.tp20
https://doi.org/10.1161/str.53.suppl_1.tp20
Autor:
Mohammad Iqbal H. Bhuiyan, Sydney Fischer, Shivani M. Patel, Helena Oft, Ting Zhang, Lesley M. Foley, Jinwei Zhang, T. Kevin Hitchens, Bradley J. Molyneaux, Xianming Deng, Dandan Sun
Publikováno v:
Neurochemistry International. 162:105441
SPAK inhibitor ZT-1a was previously shown to be neuroprotective in murine ischemic stroke models. In this study, we further examined the efficacy of four ZT-1a derivatives (ZT-1c, -1d, -1g and -1h) on reducing stroke-induced sensorimotor function imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f863692a7dc3bc3a783959244d1036c2
https://doi.org/10.1016/j.neuint.2022.105441
https://doi.org/10.1016/j.neuint.2022.105441