Výsledky vyhledávání - "Bradley J, Behnke"

Akademický článek

Pulmonary hypertension alters blood flow distribution and impairs the hyperemic response in the rat diaphragm

Autor: Kiana M. Schulze, Andrew G. Horn, Ramona E. Weber, Bradley J. Behnke, David C. Poole, Timothy I. Musch

Publikováno v: Frontiers in Physiology, Vol 14 (2023)

Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling, respiratory muscle and cardiac impairments, and exercise intolerance. Specifically, impaired gas exchange increases work of the diaphragm; however, compromised contractile

Externí odkaz: https://doaj.org/article/a42085f5bca846f98c4a8302d5e5253f

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Akademický článek

Impaired microvascular reactivity in patients treated with 5-fluorouracil chemotherapy regimens: Potential role of endothelial dysfunction

Autor: Stephen T. Hammond, Dryden R. Baumfalk, Shannon K. Parr, Alec L.E. Butenas, Britton C. Scheuermann, Vanessa-Rose G. Turpin, Bradley J. Behnke, Mehmood H. Hashmi, Carl J. Ade

Publikováno v: International Journal of Cardiology: Heart & Vasculature, Vol 49, Iss , Pp 101300- (2023)

Background: 5-fluorouracil (5-FU) is the second most common cancer chemotherapy associated with short- and long-term cardiotoxicity. Although the mechanisms mediating these toxicities are not well understood, patients often present with symptoms sugg

Externí odkaz: https://doaj.org/article/a9209611a23c4955aa220c7b3f72a99e

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Akademický článek

Head‐up tilt does not enhance prostate tumor perfusion or oxygenation in young rats

Autor: Olivia N. Kunkel, Taylor A. Rand, Joseph G. Pyle, Dryden R. Baumfalk, Andrew G. Horn, Alexander B. Opoku‐Acheampong, Carl J. Ade, Timothy I. Musch, Michael W. Ramsey, Michael D. Delp, Bradley J. Behnke

Publikováno v: Physiological Reports, Vol 10, Iss 24, Pp n/a-n/a (2022)

Abstract Solid tumors contain hypoxic regions that contribute to anticancer therapy resistance. Thus, mitigating tumor hypoxia may enhance the efficacy of radiation therapy which is commonly utilized for patients with prostate cancer. Increasing perf

Externí odkaz: https://doaj.org/article/84675b9f2d4c4ba5a87a23269584ba48

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Supplemental oxygen administration during mechanical ventilation reduces diaphragm blood flow and oxygen delivery

Autor: Andrew G. Horn, Olivia N. Kunkel, Kiana M. Schulze, Dryden R. Baumfalk, Ramona E. Weber, David C. Poole, Bradley J. Behnke

Publikováno v: J Appl Physiol (1985)

During mechanical ventilation (MV), supplemental oxygen (O(2)) is commonly administered to critically ill patients to combat hypoxemia. Previous studies demonstrate that hyperoxia exacerbates MV-induced diaphragm oxidative stress and contractile dysf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581a77da7046be4154c0c2dfca664b1b
https://pubmed.ncbi.nlm.nih.gov/35323060

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Prolonged mechanical ventilation increases diaphragm arteriole circumferential stretch without changes in stress/stretch: Implications for the pathogenesis of ventilator‐induced diaphragm dysfunction

Autor: Dryden R. Baumfalk, Olivia N. Kunkel, David C. Poole, Bradley J. Behnke, Kiana M. Schulze, Wei-Wen Hsu, Mikaela Elizabeth Simon, Andrew G. Horn, Judy M. Muller-Delp

Publikováno v: Microcirculation. 28

INTRODUCTION Prolonged mechanical ventilation (MV; ≥6 h) results in large, time-dependent reductions in diaphragmatic blood flow and shear stress. We tested the hypothesis that MV would impair the structural and material properties (ie, increased s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22403b9014568270b8f59575a856383
https://doi.org/10.1111/micc.12727

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Impaired diaphragm resistance vessel vasodilation with prolonged mechanical ventilation

Autor: Olivia N. Kunkel, Andrew G. Horn, Bradley J. Behnke, Danielle J. McCullough, Dryden R. Baumfalk, David C. Poole, Robert T. Davis rd, Alexander B. Opoku-Acheampong, Christian S. Bruells

Publikováno v: J Appl Physiol (1985)

Mechanical ventilation (MV) is a life-saving intervention, yet with prolonged MV (i.e., ≥6 h) there are time-dependent reductions in diaphragm blood flow and an impaired hyperemic response of unknown origin. Female Sprague-Dawley rats (4–8 mo, n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcfb5b1debca8feb54c377599aa0f658
https://doi.org/10.1152/japplphysiol.00189.2019

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