Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Bradley I. Reinfeld"'
Autor:
Evan B. Glass, Alyssa A. Hoover, Kennady K. Bullock, Matthew Z. Madden, Bradley I. Reinfeld, Whitney Harris, Dominique Parker, Demetra H. Hufnagel, Marta A. Crispens, Dineo Khabele, W. Kimryn Rathmell, Jeffrey C. Rathmell, Andrew J. Wilson, Todd D. Giorgio, Fiona E. Yull
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-19 (2022)
Abstract Background Current cancer immunotherapies have made tremendous impacts but generally lack high response rates, especially in ovarian cancer. New therapies are needed to provide increased benefits. One understudied approach is to target the l
Externí odkaz:
https://doaj.org/article/695878c019a54c44a19092e66e5e5079
Autor:
Paolo A. Ascierto, Lisa H. Butterfield, Katie Campbell, Bruno Daniele, Michael Dougan, Leisha A. Emens, Silvia Formenti, Filip Janku, Samir N. Khleif, Tomas Kirchhoff, Alessandro Morabito, Yana Najjar, Paul Nathan, Kunle Odunsi, Akash Patnaik, Chrystal M. Paulos, Bradley I. Reinfeld, Heath D. Skinner, John Timmerman, Igor Puzanov
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-20 (2021)
Abstract Over the last few years, numerous clinical trials and real-world experience have provided a large amount of evidence demonstrating the potential for long-term survival with immunotherapy agents across various malignancies, beginning with mel
Externí odkaz:
https://doaj.org/article/9bf022f4904a44f583c759901d1d9f53
Autor:
Keene L Abbott, Ahmed Ali, Bradley I Reinfeld, Amy Deik, Sonu Subudhi, Madelyn D Landis, Rachel A Hongo, Kirsten L Young, Tenzin Kunchok, Christopher S Nabel, Kayla D Crowder, Johnathan R Kent, Maria Lucia L Madariaga, Rakesh K Jain, Kathryn E Beckermann, Caroline A Lewis, Clary B Clish, Alexander Muir, W Kimryn Rathmell, Jeffrey Rathmell, Matthew G Vander Heiden
Publikováno v:
eLife, Vol 13 (2024)
The tumor microenvironment is a determinant of cancer progression and therapeutic efficacy, with nutrient availability playing an important role. Although it is established that the local abundance of specific nutrients defines the metabolic paramete
Externí odkaz:
https://doaj.org/article/3b4cd2338c48457fa0f024644fdf44e6
Autor:
Connor J. Beebout, Gabriella L. Robertson, Bradley I. Reinfeld, Alexandra M. Blee, Grace H. Morales, John R. Brannon, Walter J. Chazin, W. Kimryn Rathmell, Jeffrey C. Rathmell, Vivian Gama, Maria Hadjifrangiskou
Publikováno v:
Nat Microbiol
Urinary tract infections are among the most common human bacterial infections and place a significant burden on healthcare systems due to associated morbidity, cost, and antibiotic use. Despite being a facultative anaerobe, uropathogenic Escherichia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade45698889a88dd2a2d3accefdf47c8
https://doi.org/10.1038/s41564-022-01205-w
https://doi.org/10.1038/s41564-022-01205-w
Autor:
Jackie E. Bader, Melissa M. Wolf, Matthew Z. Madden, Bradley I. Reinfeld, Emily N. Arner, Emma S. Hathaway, KayLee K. Steiner, Gabriel A. Needle, Madelyn D. Landis, Matthew A. Cottam, Xiang Ye, Anthos Christofides, Vassiliki A. Boussiotis, Scott M. Haake, Kathryn E. Beckermann, W. Kimryn Rathmell, Alyssa H. Hasty, Jeffrey C. Rathmell
SummaryObesity is a leading risk factor for progression and metastasis of many cancers1,2, yet can also promote improved survival for some cancers3-5and enhance responses to some immune checkpoint blockade therapies6-8. The role of the immune system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49d0164754ab7126af577d9ebfafebf8
https://doi.org/10.1101/2022.11.12.515348
https://doi.org/10.1101/2022.11.12.515348
Autor:
Bradley I. Reinfeld, Andrew R. Patterson, Rachel E. Brown, Allison S. Cohen, Matthew H. Wilson, Anna Chytil, M. Noor Tantawy, Vera M. Todd, W. David Merryman, Jeffrey C. Rathmell, H. Charles Manning, Matthew G. Vander Heiden, Jackie E. Bader, Matthew Z. Madden, Abin Abraham, Alexander Muir, Frank M. Mason, Ahmed Ali, Christopher S. Williams, Richard T. O’Neil, Brian T. Do, Ayaka Sugiura, Tessa Huffstater, Kirsten Young, Rachelle W. Johnson, Caroline A. Lewis, Melissa M. Wolf, Emily F. Mason, Katherine E. Beckermann, W. Kimryn Rathmell, Fuxue Xin, Rachel Hongo
Publikováno v:
Nature. 593:282-288
Cancer cells characteristically consume glucose through Warburg metabolism1, a process that forms the basis of tumour imaging by positron emission tomography (PET). Tumour-infiltrating immune cells also rely on glucose, and impaired immune cell metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd19c20858dbb625ae521c410a238aec
https://doi.org/10.1038/s41586-021-03442-1
https://doi.org/10.1038/s41586-021-03442-1
Autor:
Evan B. Glass, Alyssa A. Hoover, Kennady K. Bullock, Matthew Z. Madden, Bradley I. Reinfeld, Whitney Harris, Dominique Parker, Demetra H. Hufnagel, Marta A. Crispens, Dineo Khabele, W. Kimryn Rathmell, Jeffrey C. Rathmell, Andrew J. Wilson, Todd D. Giorgio, Fiona E. Yull
Publikováno v:
BMC cancer. 22(1)
Background Current cancer immunotherapies have made tremendous impacts but generally lack high response rates, especially in ovarian cancer. New therapies are needed to provide increased benefits. One understudied approach is to target the large popu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0ab065299d161f657efeffe543ebde
https://pubmed.ncbi.nlm.nih.gov/35513776
https://pubmed.ncbi.nlm.nih.gov/35513776
Autor:
Michael R. Savona, Paul Brent Ferrell, Bradley I. Reinfeld, Brian O. Bachmann, Madison T. Wright, Gary A. Sulikowski, Rathmell Wk, John L. Rubinstein, Lars Plate, Haiyang Guo, Benjamin J. Reisman, Haley E. Ramsey
Cancer cells have long been recognized to exhibit unique bioenergetic requirements. The apoptolidin family of glycomacrolides are distinguished by their selective cytotoxicity towards oncogene transformed cells, yet their molecular mechanism remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6461d9d11637bdcf143daa04267a41c1
https://doi.org/10.1101/2021.05.31.445492
https://doi.org/10.1101/2021.05.31.445492
Autor:
P. Brent Ferrell, Madison T. Wright, Benjamin J. Reisman, Lars Plate, Hui Guo, Bradley I. Reinfeld, Michael R. Savona, Brian O. Bachmann, Gary A. Sulikowski, W. Kimryn Rathmell, John L. Rubinstein, Haley E. Ramsey
Publikováno v:
Nature chemical biology. 18(4)
Cancer cells have long been recognized to exhibit unique bioenergetic requirements. The apoptolidin family of glycomacrolides are distinguished by their selective cytotoxicity towards oncogene-transformed cells, yet their molecular mechanism remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2a8eef8d7705a6ccd271bc4aa7588c
https://pubmed.ncbi.nlm.nih.gov/34857957
https://pubmed.ncbi.nlm.nih.gov/34857957
Autor:
Paul Nathan, Michael Dougan, Chrystal M. Paulos, Silvia C. Formenti, Katie M. Campbell, Paolo A. Ascierto, Alessandro Morabito, Yana G. Najjar, Lisa H. Butterfield, John M. Timmerman, Filip Janku, Akash Patnaik, Samir N. Khleif, Leisha A. Emens, Bruno Daniele, Bradley I. Reinfeld, Heath D. Skinner, Tomas Kirchhoff, Igor Puzanov, Kunle Odunsi
Publikováno v:
Journal of translational medicine, vol 19, iss 1
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-20 (2021)
Journal of Translational Medicine
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-20 (2021)
Journal of Translational Medicine
Over the last few years, numerous clinical trials and real-world experience have provided a large amount of evidence demonstrating the potential for long-term survival with immunotherapy agents across various malignancies, beginning with melanoma and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a87c7662f5edb6843056f3a9723fcf2
https://escholarship.org/uc/item/2178563t
https://escholarship.org/uc/item/2178563t