Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Bradley G. Klein"'
A glutamate concentration‐biased allosteric modulator potentiates NMDA‐induced ion influx in neurons
Autor:
Blaise M. Costa, Lina Cortés Kwapisz, Brittney Mehrkens, Douglas N. Bledsoe, Bryanna N. Vacca, Tullia V. Johnston, Rehan Razzaq, Dhanasekaran Manickam, Bradley G. Klein
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)
Abstract Precisely controlled synaptic glutamate concentration is essential for the normal function of the N‐methyl D‐aspartate (NMDA) receptors. Atypical fluctuations in synaptic glutamate homeostasis lead to aberrant NMDA receptor activity that
Externí odkaz:
https://doaj.org/article/af4e8464cbf4484c997b749172315022
Autor:
Douglas Bledsoe, Ceyhun Tamer, Ivana Mesic, Christian Madry, Bradley G. Klein, Bodo Laube, Blaise M. Costa
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
N-methyl D-aspartate receptors (NMDAR) play crucial role in normal brain function and pathogenesis of neurodegenerative and psychiatric disorders. Functional tetra-heteromeric NMDAR contains two obligatory GluN1 subunits and two identical or differen
Externí odkaz:
https://doaj.org/article/20aef99d51994890a5f738536e18bb13
Autor:
Rehan Razzaq, Bradley G. Klein, Blaise M. Costa, Tullia V. Johnston, Bryanna N. Vacca, Douglas N. Bledsoe, Dhanasekaran Manickam, Lina Cortés Kwapisz, Brittney Mehrkens
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)
Precisely controlled synaptic glutamate concentration is essential for the normal function of the N‐methyl D‐aspartate (NMDA) receptors. Atypical fluctuations in synaptic glutamate homeostasis lead to aberrant NMDA receptor activity that results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7040629e3e67dff531be67cd53f89f3
https://doi.org/10.1002/prp2.859
https://doi.org/10.1002/prp2.859
Publikováno v:
Somatosensorymotor research. 38(3)
Satellite glial cells (SGC) surrounding neurons in sensory ganglia can buffer extracellular potassium, regulating the excitability of injured neurons and possibly influencing a shift from acute to neuropathic pain. SGC apoptosis may be a key componen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0666a3b15ab74a1f399b42ff65251099
https://pubmed.ncbi.nlm.nih.gov/34187291
https://pubmed.ncbi.nlm.nih.gov/34187291
Autor:
Michael Mykins, Richard Helm, Stuart S. Berr, Blaise M. Costa, Douglas Bledsoe, Tyler Lucas, Todd A. Sasser, Bradley G. Klein, Hope Tobey, Caroline Campbell, Per Gunnar Brolinson
Publikováno v:
J Am Osteopath Assoc
Context In the aging brain, reduction in the pulsation of cerebral vasculature and fluid circulation causes impairment in the fluid exchange between different compartments and lays a foundation for the neuroinflammation that results in Alzheimer dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc6068768521309bc4b5dd301a22dab
https://doi.org/10.7556/jaoa.2019.121
https://doi.org/10.7556/jaoa.2019.121
Publikováno v:
European Journal of Pharmacology. 844:216-224
N-methyl D-aspartate (NMDA) receptors play a crucial role in normal brain function, pathogenesis of neurodegenerative and psychiatric disorders. Functional tetra-heteromeric NMDA receptor contains two obligatory GluN1 subunits and two identical or di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9b0c6b1b3d5683d31d2b701153c5d2
https://doi.org/10.1016/j.ejphar.2018.12.023
https://doi.org/10.1016/j.ejphar.2018.12.023
Autor:
Ramu Anandakrishnan, Hope Tobey, Steven Nguyen, Osscar Gonzalez Sandoval, Bradley G. Klein, Blaise M. Costa
Age dependent dementia is a devastating disorder afflicting the growing older population around the world. Although pharmacological agents improve symptoms of dementia, age related co-morbidities combined with adverse effects often outweigh their cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9afe7a267bbbae88ada7bc345a0301db
https://doi.org/10.21203/rs.3.rs-96274/v1
https://doi.org/10.21203/rs.3.rs-96274/v1
Autor:
Ramu Anandakrishnan, Hope Tobey, Steven Nguyen, Osscar Gonzalez Sandoval, Bradley G. Klein, Blaise M. Costa
Age dependent dementia is a devastating disorder afflicting the growing older population around the world. Although pharmacological agents improve symptoms of dementia, age related co-morbidities combined with adverse effects often outweigh their cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::879b05c57d6bb4f5829e5eda7fc9ed3a
https://doi.org/10.21203/rs.3.rs-76112/v1
https://doi.org/10.21203/rs.3.rs-76112/v1
Autor:
Per Gunnar Brolinson, Tyler Lucas, Bradley G. Klein, Stuart S. Berr, Blaise M. Costa, Brittney Mehrkens, Soumen Paul, Hope Tobey
Publikováno v:
Journal of Alzheimer's disease : JAD. 74(2)
Current advancements in neurovascular biology relates a mechanoceutics treatment, known as cranial osteopathic manipulation (COM), Alzheimer's disease (AD). COM could be used as an evidence-based treatment strategy to improve the symptoms of AD if mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53a3d387175273ac8c2e3643700e1bc
https://pubmed.ncbi.nlm.nih.gov/32039851
https://pubmed.ncbi.nlm.nih.gov/32039851
Autor:
Bradley G. Klein
Publikováno v:
Cunningham's Textbook of Veterinary Physiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9cd0eee73f99c4c8b462181db0daf15
https://doi.org/10.1016/b978-0-323-55227-1.00011-9
https://doi.org/10.1016/b978-0-323-55227-1.00011-9