Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Bradley E. Britigan"'
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 8, Pp 9149-9161 (2024)
Metals play vital roles in biological systems, with iron/heme being essential for cellular and metabolic functions necessary for survival and/or virulence in many bacterial pathogens. Given the rise of bacterial resistance to current antibiotics, the
Externí odkaz:
https://doaj.org/article/e8aded63cce24392b078b6768ea42920
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-4 (2021)
Externí odkaz:
https://doaj.org/article/3f0eaf919c234b1ba3fd2532bebaa57d
Publikováno v:
mSphere, Vol 4, Iss 4 (2019)
ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a global threat. The course of TB is negatively impacted by coexistent infection with human immunodeficiency virus type 1 (HIV). Macrophage infection with these pathogens modul
Externí odkaz:
https://doaj.org/article/0ec1f10b4c5244c699ae66c75232b0cb
Publikováno v:
Redox Biology, Vol 4, Iss C, Pp 328-339 (2015)
Mycobacterium abscessus (M.abs) is a rapidly growing mycobacterial species that infects macrophages, and is an important pathogen in patients with cystic fibrosis. We studied the early stages of M.abs infection of macrophages, with emphasis on the ro
Externí odkaz:
https://doaj.org/article/ea10cf1304cf42ea8c57b09c4bd10b85
Publikováno v:
ACS Infectious Diseases. 9:716-738
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92135539417c896391672860323c4fb4
https://doi.org/10.1021/acsinfecdis.3c00050
https://doi.org/10.1021/acsinfecdis.3c00050
Autor:
Zachary W. Scott, Seoung-ryoung Choi, Geoffrey A. Talmon, Bradley E. Britigan, Prabagaran Narayanasamy
Publikováno v:
ACS Infectious Diseases. 8:2096-2105
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eebcb18f4061ae82fd1817b17a7eef1
https://doi.org/10.1021/acsinfecdis.2c00196
https://doi.org/10.1021/acsinfecdis.2c00196
Publikováno v:
ACS Infectious Diseases. 7:2299-2309
The emergence of drug-resistant pathogens causes the greatest challenge for drug development research. Recently, gallium(III)-based compounds have received great attention as novel antimicrobial agents against drug-resistant pathogens. Here, we synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03b0683735b0897056a9a8e17e9fb26f
https://doi.org/10.1021/acsinfecdis.0c00896
https://doi.org/10.1021/acsinfecdis.0c00896
Publikováno v:
ACS Infectious Diseases. 6:2582-2591
There is an urgent need for new effective and safe antibiotics active against pathogenic mycobacterial species. Gallium (Ga) nitrate (Ga(NO3)3) and Ga porphyrin (GaPP) have each been shown to inhibit the growth of a variety of mycobacterial species.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2da030bbbcddec2045cd836cbe1bbd63
https://doi.org/10.1021/acsinfecdis.0c00113
https://doi.org/10.1021/acsinfecdis.0c00113
Publikováno v:
ACS Infectious Diseases. 5:1559-1569
Iron- and heme-uptake pathways and metabolism are promising targets for the development of new antimicrobial agents, as their disruption would lead to nutritional iron starvation and inhibition of ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2aad660d5e920deae172557bfe8554b
https://doi.org/10.1021/acsinfecdis.9b00100
https://doi.org/10.1021/acsinfecdis.9b00100
Autor:
Christopher Thompson, Katie Bailey, Maher Y. Abdalla, H. Carlo Maurer, Kenneth P. Olive, Sushil Kumar, Kasturi Banerjee, Satyanarayana Rachagani, Iman M. Ahmad, Bradley E. Britigan
Publikováno v:
Translational Research. 207:56-69
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies and has one of the worst prognoses leading to a meager 5-year survival rate of ∼8%. Chemotherapy has had limited success in extending the life span of patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9289857b4b55b1690fa5f602a72aaabc
https://doi.org/10.1016/j.trsl.2018.12.008
https://doi.org/10.1016/j.trsl.2018.12.008