Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Bradley D. Tait"'
Autor:
Nina R. Ortiz, Laura J. Blair, Marc B. Cox, Jeffrey C. Sivils, David S. Culbertson, Jane Dyson, Ashley N Payan, Dan Finley, Jazzmin Jovonna Owens, Jason E. Gestwicki, Szu Yu Kuo, William E. Balch, Jaideep Chaudhary, Jay Singh, Darren M. Hutt, Chad A. Dickey, Naihsuan Guy, Bradley D. Tait, Shravan Kumar Komaragiri
Publikováno v:
Cell chemical biology, vol 27, iss 3
Cell Chem Biol
Cell Chem Biol
Summary Hsp90 plays an important role in health and is a therapeutic target for managing misfolding disease. Compounds that disrupt co-chaperone delivery of clients to Hsp90 target a subset of Hsp90 activities, thereby minimizing the toxicity of pan-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c800b824e420391f461894a73274c69
https://escholarship.org/uc/item/3k55j4vx
https://escholarship.org/uc/item/3k55j4vx
Autor:
Matthew Cullen, Cecilia M. Bastos, Lawrence Drew, Danijela Dukovski, Benito Munoz, Kenneth A. Giuliano, Shinichiro Wachi, Po-Shun Lee, Sheila Hauck, Olivia Green, Bradley D. Tait, John P. Miller
Publikováno v:
Slas Discovery
Cystic fibrosis (CF) is a lethal genetic disorder caused by mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Despite recent groundbreaking approval of genotype-specific small-molecule drugs, a significant portion of CF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0ad75dc6470779f40014d6f7a23b0b
https://doi.org/10.1177/2472555217729790
https://doi.org/10.1177/2472555217729790
Autor:
Marc B. Cox, Jay Singh, David S. Culbertson, William E. Balch, Darren M. Hutt, Chad A. Dickey, Naihsuan Guy, Bradley D. Tait, Jane Dyson, Jeffrey C. Sivils, Szu Yu Kuo, Jason E. Gestwicki
The core cytosolic Hsp90 chaperone/co-chaperone complex plays a critical role in proteostasis management of human health and disease. To identify novel compounds that alter the ability of the Hsp90 co-chaperone Aha1 to modulate the ATPase activity fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f853874b526418c3bf886b9aa7a25c43
https://doi.org/10.1101/412908
https://doi.org/10.1101/412908
Autor:
Richard I. Morimoto, Dan Garza, Darren M. Hutt, Shilpi Khanna, Maria Catarina Silva, Barbara Calamini, Bradley D. Tait, S. Adrian Saldanha, Monica A. Chalfant, William E. Balch, Franck Madoux, Peter Hodder
Publikováno v:
Nature chemical biology
Protein homeostasis (proteostasis) is essential for cellular and organismal health. Stress, aging and the chronic expression of misfolded proteins, however, challenge the proteostasis machinery and the vitality of the cell. Enhanced expression of mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3117a915694ae86c5bc2afc07502a41d
https://doi.org/10.1038/nchembio.763
https://doi.org/10.1038/nchembio.763
Autor:
John P. Miller, Bradley D. Tait
Cystic fibrosis is a genetic disease caused by mutations in the CFTR (cystic fibrosis transmembrane conductance regulator) gene that affect transcription, folding, trafficking, degradation, or channel opening of the protein. The lack of CFTR chloride
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99cc21db78cb882cc4ee0230f2ba507a
https://doi.org/10.1016/b978-0-12-800167-7.00020-1
https://doi.org/10.1016/b978-0-12-800167-7.00020-1
Autor:
Bradley D. Tait, Susan Elizabeth Hagen, Michael Lovdahl, Eric Andrew Zeikus, Carolyn Nouhan, Joanne Brodfuehrer, Donald Hupe, Christopher Andrew Gajda, John M. Domagala, Greg Zeikus, Elizabeth A. Lunney, Steve Vanderroest, Alexander Pavlovsky, Andrej Urumov, James Saunders, Stephen J. Gracheck, Eric Wise, Tod P. Holler
Publikováno v:
Journal of Medicinal Chemistry. 44:2319-2332
Due largely to the emergence of multi-drug-resistant HIV strains, the development of new HIV protease inhibitors remains a high priority for the pharmaceutical industry. Toward this end, we previously identified a 4-hydroxy-5,6-dihydropyrone lead com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad77410f5a7953272458465fb613cb5
https://doi.org/10.1021/jm0003844
https://doi.org/10.1021/jm0003844
Identifying small molecule regulators of the Proteostasis Network that enhance CFTR protein function
Autor:
Dan Garza, William E. Balch, Shilpi Khanna, Matthew Cullen, Kenneth A. Giuliano, Yitan Zhu, Shinichiro Wachi, Peter H. Reinhart, Hui Ge, Jennifer Andersen, Wesley Dobbs, Lawrence Drew, John P. Miller, Bradley D. Tait, Darren M. Hutt
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bb3b6accb8bd48c513543ef972a5a6f
https://doi.org/10.1096/fasebj.27.1_supplement.lb125
https://doi.org/10.1096/fasebj.27.1_supplement.lb125
Autor:
Erasga Noe Ouano, David C. Boyles, Chitase Lee, Vaishali Sahasrabudhe, Emi Kimoto, Mark C. Kowala, Yurong Lai, Jonathan Chupka, Bharat K. Trivedi, Xue-Min Cheng, Jeffrey C. Hanselman, Valerie Askew, Zhiwu Lin, P. L. Barclay, Bruce Auerbach, David B. Duignan, Jeffrey A. Pfefferkorn, Theunis C. Goosen, Bo Feng, Lisa Dillon, Richard H. Hutchings, Andrew Robertson, Robert M. Kennedy, Bradley D. Tait, Ayman El-Kattan, Scott D. Larsen, Gina Lu, Daniel Merritt Bowles, Vu Le, Mark Milad, Erick Kindt, Karl Olsen, Mark Richard Bush, John Litchfield, Carine Boustany, Rebecca Bakker-Arkema, Renato J. Scialis, Yi An Bi, Catherine Sekerke, Jaap Mandema, Karen Atkinson
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(9)
The design of drugs with selective tissue distribution can be an effective strategy for enhancing efficacy and safety, but understanding the translation of preclinical tissue distribution data to the clinic remains an important challenge. As part of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944f1fb672305f2baa7a70a0ffb7d328
https://pubmed.ncbi.nlm.nih.gov/21183342
https://pubmed.ncbi.nlm.nih.gov/21183342
Autor:
Richard H. Hutchings, Gina Lu, William Keun Chan Park, Mark C. Kowala, Melissa S. Harris, Chulho Choi, Valerie Askew, Bradley D. Tait, Catherine Sekerke, Scott D. Larsen, Jeffrey A. Pfefferkorn, Lisa Dillon, Alexander Pavlovsky, Nicole Caspers, Graeme Bainbridge, Bruce Auerbach, Jeffrey C. Hanselman, Andrew Robertson, Zhiwu Lin
Publikováno v:
Journal of medicinal chemistry. 51(1)
In light of accumulating evidence that aggressive LDL-lowering therapy may offer increased protection against coronary heart disease, we undertook the design and synthesis of a novel series of HMG-CoA reductase inhibitors based upon a substituted pyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0703f3ce9b0b0f406d7f05a0f27aaabe
https://pubmed.ncbi.nlm.nih.gov/18072721
https://pubmed.ncbi.nlm.nih.gov/18072721
Autor:
Andrew Robertson, Gina Lu, Catherine Sekerke, Bruce A. Steinbaugh, Robert M. Kennedy, Scott D. Larsen, Bruce D. Roth, Mark C. Kowala, Valerie Askew, Bharat K. Trivedi, Kevin Sun, Steve Miller, Yuntao Song, Jeffrey C. Hanselman, Lisa Dillon, William Keun Chan Park, Bradley D. Tait, Bruce Auerbach, Zhiwu Lin
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(3)
4-Sulfamoyl pyrroles were designed as novel hepatoselective HMG-CoA reductase inhibitors (statins) to reduce myalgia, a statin-induced adverse effect. The compounds were prepared via a [3 + 2] cycloaddition of a Munchnone with a sulfonamide-substitut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529bbd001cc056a0d63562fa2b448f60
https://pubmed.ncbi.nlm.nih.gov/18155906
https://pubmed.ncbi.nlm.nih.gov/18155906