Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Bradley D. Shields"'
Autor:
Bradley D. Shields, Fade Mahmoud, Erin M. Taylor, Stephanie D. Byrum, Deepanwita Sengupta, Brian Koss, Giulia Baldini, Seth Ransom, Kyle Cline, Samuel G. Mackintosh, Ricky D. Edmondson, Sara Shalin, Alan J. Tackett
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Modulation of the immune system can produce anti-tumor responses in various cancer types, including melanoma. Recently, immune checkpoint inhibitors (ICI), in single agent and combination regimens, have produced durable and long-lasting clin
Externí odkaz:
https://doaj.org/article/cef50263e016446d94ea892a09c098c1
Autor:
Alan J. Tackett, Sara C. Shalin, Fade Mahmoud, Rick Edmondson, Samuel G. Mackintosh, Stephanie D. Byrum, Kirk L. West, Aaron J. Storey, Erin M. Taylor, Brian Koss, Bradley D. Shields
Figure S1- B16.Ecad and B16.Vector lung metastases in Rag 1-/- mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4366b0ef32935f9e3a82516ad8197c
https://doi.org/10.1158/0008-5472.22422587.v1
https://doi.org/10.1158/0008-5472.22422587.v1
Autor:
Alan J. Tackett, Gang Greg Wang, Thomas F. Gajewski, Nukhet Aykin-Burns, Rick D. Edmondson, Samuel G. Mackintosh, Tung-Chin Chiang, Kimberly J. Krager, Jason B. Williams, Hidetaka Uryu, Jeong Hyun Ahn, Samrat Roy Choudhury, Charity L. Washam, Allen J. Gies, Stephanie D. Byrum, Aaron J. Storey, Erin M. Taylor, Bradley D. Shields, Brian Koss
T-cell exhaustion in cancer is linked to poor clinical outcomes, where evidence suggests T-cell metabolic changes precede functional exhaustion. Direct competition between tumor-infiltrating lymphocytes (TIL) and cancer cells for metabolic resources
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2aed658cb8479aa41c12a11abbf7a0
https://doi.org/10.1158/0008-5472.c.6512143.v1
https://doi.org/10.1158/0008-5472.c.6512143.v1
Autor:
Alan J. Tackett, Gang Greg Wang, Thomas F. Gajewski, Nukhet Aykin-Burns, Rick D. Edmondson, Samuel G. Mackintosh, Tung-Chin Chiang, Kimberly J. Krager, Jason B. Williams, Hidetaka Uryu, Jeong Hyun Ahn, Samrat Roy Choudhury, Charity L. Washam, Allen J. Gies, Stephanie D. Byrum, Aaron J. Storey, Erin M. Taylor, Bradley D. Shields, Brian Koss
Figure S1-7. Figure S1: Assessing the effect of EZH2i on in vitro T cell cytotoxic function. Figure S2: Systems approach uncovers drivers of T cell exhaustion resulting from EZH2-inhibtion. Figure S3: Loss of EZH2 function leads to metabolic exhausti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7199995713bf285261746195a1b94520
https://doi.org/10.1158/0008-5472.22425820
https://doi.org/10.1158/0008-5472.22425820
Autor:
Alan J. Tackett, Sara C. Shalin, Fade Mahmoud, Rick Edmondson, Samuel G. Mackintosh, Stephanie D. Byrum, Kirk L. West, Aaron J. Storey, Erin M. Taylor, Brian Koss, Bradley D. Shields
Identifying controlling features of responsiveness to checkpoint blockade therapies is an urgent goal in oncology research. Our group and others have previously shown melanoma tumors resistant to checkpoint blockade display features of mesenchymal tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09a61524af7276e79003b9bbc1024534
https://doi.org/10.1158/0008-5472.c.6511277.v1
https://doi.org/10.1158/0008-5472.c.6511277.v1
Autor:
Jeong Hyun Ahn, Kimberly J. Krager, Allen Gies, Rick D. Edmondson, Jason B. Williams, Bradley D. Shields, Samuel G. Mackintosh, Tung-Chin Chiang, Stephanie D. Byrum, Hidetaka Uryu, Samrat Roy Choudhury, Alan J. Tackett, Charity L. Washam, Erin M. Taylor, Thomas F. Gajewski, Nukhet Aykin-Burns, Aaron J. Storey, Gang Greg Wang, Brian Koss
Publikováno v:
Cancer Research. 80:4707-4719
T-cell exhaustion in cancer is linked to poor clinical outcomes, where evidence suggests T-cell metabolic changes precede functional exhaustion. Direct competition between tumor-infiltrating lymphocytes (TIL) and cancer cells for metabolic resources
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e02e290324059e6c8ea42e933fe93d0
https://doi.org/10.1158/0008-5472.can-20-0524
https://doi.org/10.1158/0008-5472.can-20-0524
Autor:
Bradley D. Shields, Brian Koss, Erin M. Taylor, Sara C. Shalin, Stephanie D. Byrum, Fade Mahmoud, Aaron J. Storey, Alan J. Tackett, Rick D. Edmondson, Samuel G. Mackintosh, Kirk West
Publikováno v:
Cancer Research. 79:1113-1123
Identifying controlling features of responsiveness to checkpoint blockade therapies is an urgent goal in oncology research. Our group and others have previously shown melanoma tumors resistant to checkpoint blockade display features of mesenchymal tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7314f0cab8382319dbf0bcfa11474c
https://doi.org/10.1158/0008-5472.can-18-1722
https://doi.org/10.1158/0008-5472.can-18-1722
Autor:
Brian, Koss, Bradley D, Shields, Erin M, Taylor, Aaron J, Storey, Stephanie D, Byrum, Allen J, Gies, Charity L, Washam, Samrat Roy, Choudhury, Jeong, Hyun Ahn, Hidetaka, Uryu, Jason B, Williams, Kimberly J, Krager, Tung-Chin, Chiang, Samuel G, Mackintosh, Rick D, Edmondson, Nukhet, Aykin-Burns, Thomas F, Gajewski, Gang Greg, Wang, Alan J, Tackett
Publikováno v:
Cancer Res
T cell exhaustion in cancer is linked to poor clinical outcomes, where evidence suggests T cell metabolic changes precede functional exhaustion. Direct competition between tumor-infiltrating lymphocytes (TIL) and cancer cells for metabolic resources
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8b31f19dec651c5029bb676edeffc2bf
https://pubmed.ncbi.nlm.nih.gov/33004350
https://pubmed.ncbi.nlm.nih.gov/33004350
Autor:
Fade Mahmoud, Nathan L. Avaritt, Laura F. Hutchins, Henry K. Wong, Sara C. Shalin, Bradley D. Shields, Alan J. Tackett, Issam Makhoul
Publikováno v:
Cancer Biology & Therapy. 18:451-469
Pharmacologic inhibition of the cytotoxic T lymphocyte antigen 4 (CTLA4) and the programmed death receptor-1 (PD1) has resulted in unprecedented durable responses in metastatic melanoma. However, resistance to immunotherapy remains a major challenge.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1606e32005e8efcffe1ec4bdeb8bae79
https://doi.org/10.1080/15384047.2017.1323596
https://doi.org/10.1080/15384047.2017.1323596
Autor:
Alan J. Tackett, Issam Makhoul, Laura F. Hutchins, Sara C. Shalin, Fade Mahmoud, Bradley D. Shields
Publikováno v:
Cancer Biology & Therapy. 17:579-591
There is accumulating evidence that the histone methyltransferase enhancer of zeste homolog 2 (EZH2), the main component of the polycomb-repressive complex 2 (PRC2), is involved in melanoma progression and metastasis. Novel drugs that target and reve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94501c1d0be690b3cc0ed75c35387180
https://doi.org/10.1080/15384047.2016.1167291
https://doi.org/10.1080/15384047.2016.1167291