Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Bradley C, Bundy"'
Autor:
Jacob A. Stern, Tyler J. Free, Kimberlee L. Stern, Spencer Gardiner, Nicholas A. Dalley, Bradley C. Bundy, Joshua L. Price, David Wingate, Dennis Della Corte
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Various approaches have used neural networks as probabilistic models for the design of protein sequences. These "inverse folding" models employ different objective functions, which come with trade-offs that have not been assessed in detail b
Externí odkaz:
https://doaj.org/article/bfdd2c95245d460e8f802e7b5da5c735
Autor:
Tyler J. Free, Joseph P. Talley, Chad D. Hyer, Catherine J. Miller, Joel S. Griffitts, Bradley C. Bundy
Publikováno v:
Sensors, Vol 24, Iss 10, p 3073 (2024)
Specialized cancer treatments have the potential to exploit glutamine dependence to increase patient survival rates. Glutamine diagnostics capable of tracking a patient’s response to treatment would enable a personalized treatment dosage to optimiz
Externí odkaz:
https://doaj.org/article/546889e8e7474dc9ab7f1f83cd4bcf99
Autor:
J. Porter Hunt, Tyler J. Free, Jackelyn Galiardi, Kevin M. Watt, David W. Wood, Bradley C. Bundy
Publikováno v:
Life, Vol 13, Iss 10, p 1972 (2023)
Thyroid receptor signaling controls major physiological processes and disrupted signaling can cause severe disorders that negatively impact human life. Consequently, methods to detect thyroid receptor ligands are of great toxicologic and pharmacologi
Externí odkaz:
https://doaj.org/article/3f7bf1f0c97f409fb006ab91c4f5e407
Autor:
Tyler J. Free, Ryan W. Tucker, Katelyn M. Simonson, Sydney A. Smith, Caleb M. Lindgren, William G. Pitt, Bradley C. Bundy
Publikováno v:
Biosensors, Vol 13, Iss 1, p 104 (2023)
Diagnostic blood tests can guide the administration of healthcare to save and improve lives. Most clinical biosensing blood tests require a trained technician and specialized equipment to process samples and interpret results, which greatly limits te
Externí odkaz:
https://doaj.org/article/f158bf2eb8ea44ef9316b3ea6aaf7785
Autor:
J. Porter Hunt, Emily Long Zhao, Mehran Soltani, Madison Frei, J. Andrew D. Nelson, Bradley C. Bundy
Publikováno v:
Synthetic and Systems Biotechnology, Vol 4, Iss 4, Pp 220-224 (2019)
An “endotoxin-free” E. coli-based cell-free protein synthesis system has been reported to produce therapeutic proteins rapidly and on-demand. However, preparation of the most complex CFPS reagent – the cell extract – remains time-consuming an
Externí odkaz:
https://doaj.org/article/0ac47d24b4404df2bf8c2ed1b80c3cfe
Publikováno v:
Journal of Biological Engineering, Vol 13, Iss 1, Pp 1-14 (2019)
Abstract Metabolic labeling of proteins with non-canonical amino acids (ncAAs) provides unique bioorthogonal chemical groups during de novo synthesis by taking advantage of both endogenous and heterologous protein synthesis machineries. Labeled prote
Externí odkaz:
https://doaj.org/article/dbf6b92531704e67ae7b8e97f959eebb
Autor:
Sydney A. Smith, Caleb M. Lindgren, Landon E. Ebbert, Tyler J. Free, J. Andrew D. Nelson, Katelyn M. Simonson, J. Porter Hunt, Bradley C. Bundy
Publikováno v:
Biotechnology Progress.
Autor:
Emily Long Zhao, Mehran Soltani, Addison K. Smith, J. Porter Hunt, Thomas A. Knotts, Bradley C. Bundy
Publikováno v:
Journal of Biotechnology. 345:55-63
PEGylation is a broadly used strategy to enhance the pharmacokinetic properties of therapeutic proteins. It is well established that the location and extent of PEGylation have a significant impact on protein properties. However, conventional PEGylati
Autor:
Alex B. Benedict, Chandler A. Warr, William G. Pitt, Melissa K. Takahashi, Emily Long Zhao, J. Porter Hunt, Joel S. Griffitts, Bradley C. Bundy, Tyler J. Free, Mehran Soltani
Publikováno v:
New Biotechnology
Graphical Abstract Illustration of the assembly, distribution, and point-of-care use of a rapidly-deployable, cell-free COVID-19 biosensor: 1) Assemble: Assembling CFPS reagents by mixing E. coli lysate, murine RNase Inhibitor (mRI), energy sources,
Autor:
Jacob A. Stern, Tyler J. Free, Kimberlee L. Stern, Spencer Gardiner, Nicholas A. Dalley, Bradley C. Bundy, Joshua L. Price, David Wingate, Dennis Della Corte
Several recently introduced approaches use neural networks as probabilistic models for protein sequence design. These models use various objective functions and optimization schemes. The choice of objective function and optimization scheme comes with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd814bebad2bd73744ea6accb610bfbf
https://doi.org/10.1101/2022.12.28.521825
https://doi.org/10.1101/2022.12.28.521825