Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Bradley A. Palmer"'
Autor:
Anthony L. Hessel, Michel N. Kuehn, Seong-Won Han, Weikang Ma, Thomas C. Irving, Brent A. Momb, Taejeong Song, Sakthivel Sadayappan, Wolfgang A. Linke, Bradley M. Palmer
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract In striated muscle, the sarcomeric protein myosin-binding protein-C (MyBP-C) is bound to the myosin thick filament and is predicted to stabilize myosin heads in a docked position against the thick filament, which limits crossbridge formation
Externí odkaz:
https://doaj.org/article/10a433d29a114c5bb280881b6bad3e35
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 7, Iss , Pp 100066- (2024)
Cardiac microtubules have recently been implicated in mechanical dysfunction during heart failure. However, systemic intolerance and non-cardiac effects of microtubule-depolymerizing compounds have made it challenging to determine the effect of micro
Externí odkaz:
https://doaj.org/article/745156f9599b4ed9ae49d254143bcebb
Strain rate of stretch affects crossbridge detachment during relaxation of intact cardiac trabeculae
Publikováno v:
PLoS ONE, Vol 19, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/dfe6db154a3b4c26b5f97ca0d3da5fbf
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Myocardial relaxation in late systole is enhanced by increasing velocities of lengthening. Given that inorganic phosphate (Pi) can rebind to the force-producing myosin enzyme prior to MgADP release and hasten crossbridge detachment, we hypothesized t
Externí odkaz:
https://doaj.org/article/b98fea41a46f414eae835cd11d46d36a
Autor:
Gabrielle Nelson, Bo Ye, Morgan Schock, Daniel L. Lustgarten, Elisabeth K. Mayhew, Bradley M. Palmer, Markus Meyer
Publikováno v:
Physiological Reports, Vol 10, Iss 17, Pp n/a-n/a (2022)
Abstract Historic studies with sodium ion (Na+) micropipettes and first‐generation fluorescent probes suggested that an increase in heart rate results in higher intracellular Na+‐levels. Using a dual fluorescence indicator approach, we simultaneo
Externí odkaz:
https://doaj.org/article/90e5d2234c6b4890adacef0bbda6c674
Autor:
Bradley M. Palmer, Stephen P. Bell
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
While the reductionist approach has been fruitful in understanding the molecular basis of muscle function, intact excitable muscle preparations are still important as experimental model systems. We present here methods that are useful for preparing c
Externí odkaz:
https://doaj.org/article/016e44b343724fb98b23126e0c5c18d3
Autor:
Anthony L. Hessel, Michel Kuehn, Bradley M. Palmer, Devin Nissen, Dhruv Mishra, Venus Joumaa, Johanna Freundt, Weikang Ma, Kiisa C. Nishikawa, Thomas Irving, Wolfgang A. Linke
Publikováno v:
bioRxiv
In muscle, titin proteins connect myofilaments together and are thought to be critical for contraction, especially during residual force enhancement (RFE) when force is elevated after an active stretch. We investigated titin’s function during contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98aa3b510d8447b9b20a1b337001dc1
https://europepmc.org/articles/PMC9980001/
https://europepmc.org/articles/PMC9980001/
Inertial artifact in viscoelastic measurements of striated muscle: Modeling and experimental results
Publikováno v:
Biophys J
Viscoelastic properties of striated muscle are often measured using length perturbation analysis and quantified as a complex modulus, whose elastic and viscous components reflect the energy-storage and energy-absorbing properties of the tissue, respe
Autor:
Markus Meyer, Wolfgang R. Dostmann, J. Martin, Martin M. LeWinter, Michael J. Previs, Maren E. Arnold, Bradley M. Palmer
Publikováno v:
Am J Physiol Heart Circ Physiol
The interaction of phospholamban (PLB) and the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2a) is a key regulator of cardiac contractility and a therapeutic target in heart failure (HF). PLB-mediated increases in SERCA2a activity improve cardiac funct
Autor:
Michael J. Previs, Thomas S. O’Leary, Michael P. Morley, Bradley M. Palmer, Martin LeWinter, Jaime M. Yob, Francis D. Pagani, Christopher Petucci, Min-Soo Kim, Kenneth B. Margulies, Zoltan Arany, Daniel P. Kelly, Sharlene M. Day
Publikováno v:
Circ Heart Fail
Background: Defects in energetics are thought to be central to the pathophysiology of hypertrophic cardiomyopathy (HCM); yet, the determinants of ATP availability are not known. The purpose of this study is to ascertain the nature and extent of metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b1ef40680e48687276cd37d394a34e
https://europepmc.org/articles/PMC9708114/
https://europepmc.org/articles/PMC9708114/