Zobrazeno 1 - 10
of 310
pro vyhledávání: '"Bradley A Carlson"'
Autor:
Petra A Tsuji, Bradley A Carlson, Min-Hyuk Yoo, Salvador Naranjo-Suarez, Xue-Ming Xu, Yiwen He, Esther Asaki, Harold E Seifried, William C Reinhold, Cindy D Davis, Vadim N Gladyshev, Dolph L Hatfield
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124487 (2015)
Selenoproteins mediate much of the cancer-preventive properties of the essential nutrient selenium, but some of these proteins have been shown to also have cancer-promoting effects. We examined the contributions of the 15kDa selenoprotein (Sep15) and
Externí odkaz:
https://doaj.org/article/89a6222263d041529431a46c939de9ea
Autor:
Yassin Mahdi, Xue-Ming Xu, Bradley A Carlson, Noelia Fradejas, Paul Günter, Doreen Braun, Eileen Southon, Lino Tessarollo, Dolph L Hatfield, Ulrich Schweizer
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127349 (2015)
Selenocysteine tRNA 1 associated protein (Trnau1ap) has been characterized as a tRNA[Ser]Sec-binding protein of 43 kDa, hence initially named SECp43. Previous studies reported its presence in complexes containing tRNA[Ser]Sec implying a role of SECp4
Externí odkaz:
https://doaj.org/article/27a8f4b35cf54fc684fcbf085f136c16
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e71427 (2013)
Thioredoxin (Trx) and thioredoxin reductase 1 (TR1) are among the major redox regulators in mammalian cells and have a wide variety of roles, including removal of intracellular reactive oxygen species (ROS) and prevention of cell death. Tumor necrosi
Externí odkaz:
https://doaj.org/article/ac07033f4db5454db16a16a260a08da7
Autor:
Mohamed E Moustafa, Bradley A Carlson, Miriam R Anver, Gerd Bobe, Nianxin Zhong, Jerrold M Ward, Christine M Perella, Victoria J Hoffmann, Keith Rogers, Gerald F Combs, Ulrich Schweizer, Glenn Merlino, Vadim N Gladyshev, Dolph L Hatfield
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57389 (2013)
Changes in dietary selenium and selenoprotein status may influence both anti- and pro-cancer pathways, making the outcome of interventions different from one study to another. To characterize such outcomes in a defined setting, we undertook a control
Externí odkaz:
https://doaj.org/article/d0eb1189879c4990a6bcca0f73d4e755
Autor:
Petra A Tsuji, Bradley A Carlson, Salvador Naranjo-Suarez, Min-Hyuk Yoo, Xue-Ming Xu, Dmitri E Fomenko, Vadim N Gladyshev, Dolph L Hatfield, Cindy D Davis
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50574 (2012)
Evidence suggests that selenium has cancer preventive properties that are largely mediated through selenoproteins. Our previous observations demonstrated that targeted down-regulation of the 15 kDa selenoprotein (Sep15) in murine colon cancer cells r
Externí odkaz:
https://doaj.org/article/3627b320c12a46f59ffbb0e089cd2185
Autor:
Salvador Naranjo-Suarez, Bradley A Carlson, Petra A Tsuji, Min-Hyuk Yoo, Vadim N Gladyshev, Dolph L Hatfield
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30470 (2012)
Cellular adaptation to hypoxic conditions mainly involves transcriptional changes in which hypoxia inducible factors (HIFs) play a critical role. Under hypoxic conditions, HIF protein is stabilized due to inhibition of the activity of prolyl hydroxyl
Externí odkaz:
https://doaj.org/article/23de2914af7d4f078ba66cffcd5454ee
Autor:
Virginia Rodriguez, Sona Vasudevan, Akiko Noma, Bradley A Carlson, Jeffrey E Green, Tsutomu Suzuki, Settara C Chandrasekharappa
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39297 (2012)
Posttranscriptional modifications are critical for structure and function of tRNAs. Wybutosine (yW) and its derivatives are hyper-modified guanosines found at the position 37 of eukaryotic and archaeal tRNA(Phe). TYW2 is an enzyme that catalyzes α-a
Externí odkaz:
https://doaj.org/article/03ff78ab0569444e8802e850384ee73b
Autor:
Irem Uluisik, Alaattin Kaya, Dmitri E Fomenko, Huseyin C Karakaya, Bradley A Carlson, Vadim N Gladyshev, Ahmet Koc
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27772 (2011)
Boron is an essential micronutrient for plants, and it is beneficial for animals. However, at high concentrations boron is toxic to cells although the mechanism of this toxicity is not known. Atr1 has recently been identified as a boron efflux pump w
Externí odkaz:
https://doaj.org/article/678fa5eb0c8543d2826a94f786303521
Autor:
Aniruddha Sengupta, Ulrike F Lichti, Bradley A Carlson, Andrew O Ryscavage, Vadim N Gladyshev, Stuart H Yuspa, Dolph L Hatfield
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12249 (2010)
Dietary selenium is known to protect skin against UV-induced damage and cancer and its topical application improves skin surface parameters in humans, while selenium deficiency compromises protective antioxidant enzymes in skin. Furthermore, skin and
Externí odkaz:
https://doaj.org/article/ad0f65cd83e54b3aa12dd3381a41ec0f
Autor:
Charlene M Downey, Chelsea R Horton, Bradley A Carlson, Trish E Parsons, Dolph L Hatfield, Benedikt Hallgrímsson, Frank R Jirik
Publikováno v:
PLoS Genetics, Vol 5, Iss 8, p e1000616 (2009)
Kashin-Beck disease, a syndrome characterized by short stature, skeletal deformities, and arthropathy of multiple joints, is highly prevalent in specific regions of Asia. The disease has been postulated to result from a combination of different envir
Externí odkaz:
https://doaj.org/article/637b737914934849a59b080eab2c46fb