Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Bradley Condon"'
Publikováno v:
Journal of Developmental Origins of Health and Disease. 12:539-554
Emerging evidence demonstrates a link between preterm birth (PTB) and later life cardiovascular disease (CVD). We conducted a systematic review and meta-analysis to compare conventional CVD risk factors between those born preterm and at term. PubMed,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fad328783fa3afd42e895c0b0f5005
https://doi.org/10.1017/s2040174420000914
https://doi.org/10.1017/s2040174420000914
Autor:
Stephen Antonysamy, Bradley Condon, Zhanna Druzina, Jeffrey B Bonanno, Tarun Gheyi, Feiyu Zhang, Iain MacEwan, Aiping Zhang, Sheela Ashok, Logan Rodgers, Marijane Russell, John Gately Luz
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84147 (2013)
The enhancer-of-zeste homolog 2 (EZH2) gene product is an 87 kDa polycomb group (PcG) protein containing a C-terminal methyltransferase SET domain. EZH2, along with binding partners, i.e., EED and SUZ12, upon which it is dependent for activity forms
Externí odkaz:
https://doaj.org/article/d0efb2c872af40ed96f0cf32d3038efa
Autor:
Stephen Antonysamy, Milan Maletic, Srinivasan Chandrasekhar, Michael J. Hickey, Karen Gooding, Joseph D. Ho, Anita K. Harvey, Norman Earle Hughes, Steven D. Kahl, John G. Luz, Matthew R. Lee, Kristen Aznavour, Aiping Zhang, Xiao-Peng Yu, Jonathan S. Park, Bryan H. Norman, Bradley Condon, Charles Rauch, Ashley V. Sloan
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1865:129800
Background Due to the importance of both prostaglandins (PGs) and leukotrienes (LTs) as pro-inflammatory mediators, and the potential for eicosanoid shunting in the presence of pathway target inhibitors, we have investigated an approach to inhibiting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93d058704c9d408a3ef614e240c5014
https://doi.org/10.1016/j.bbagen.2020.129800
https://doi.org/10.1016/j.bbagen.2020.129800
Autor:
Charles H. Mitch, Aiping Zhang, Mercedes Carpintero, Bradley Condon, C. Groshong, Shane Atwell, John W. Koss, Carl D Overshiner, Jeffrey M. Schkeryantz, Stephon C. Smith, Mark G. Bures, James E. Matt, S.R. Wasserman, Adam M. Fivush, Wesley Seidel, Carlos Jaramillo, K. Conners, David W. Bedwell, Jeffrey M. Witkin, Maria-Jesus Blanco, Daniel Ray Mayhugh, Steven James Quimby, Bruce A. Dressman, Keith A. Wafford, John T. Catlow, Allie Edward Tripp, Paul L. Ornstein, Mario Barberis, José Francisco Soriano, Steven Swanson, Beverly A. Heinz, Jon A. Erickson, Xia Li, Iain MacEwan, Thomas C. Britton, James A. Monn, Susana García-Cerrada, Jing Wang, Mark Donald Chappell, Eric George Tromiczak, Renhua Li, José Eugenio de Diego, Christine Sougias, Tatiana Natali Vetman, Xushan Wang, Stephen Antonysamy
Publikováno v:
Journal of Medicinal Chemistry. 59:10974-10993
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we have incorporated substitution at the C3 and C4 positions of the (1S,2R,5R,6R)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::812f4203afd8777afc4ec3e0d87f74f0
https://doi.org/10.1021/acs.jmedchem.6b01119
https://doi.org/10.1021/acs.jmedchem.6b01119
Autor:
Mark Edward Rempala, Tom Raub, Carlos Mateos, Sehila Pleite, Josh Clayton, William J. Ehlhardt, Huaxing Pei, Bradley Condon, Stephanie L. Stout, Sheela Ashok, Sandaruwan Geeganage, Mei Lai, Burkholder Timothy P, Deidre Michelle Johns, Yong Wang, Kenneth James Junior Henry, Saravanan Parthasarathy, Zhohai Lu, Oscar de Frutos, Pablo A. García
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(10)
During the course of our research efforts to develop potent and selective AKT inhibitors, we discovered enatiomerically pure substituted dihydropyridopyrimidinones (DHP) as potent inhibitors of protein kinase B/AKT with excellent selectivity against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107b14709d1a2c2930c8a82be7b68c7d
https://pubmed.ncbi.nlm.nih.gov/29655979
https://pubmed.ncbi.nlm.nih.gov/29655979
Autor:
Srinivasan Chandrasekhar, Bradley Condon, Matthew Allen Schiffler, Kuklish Steven Lee, Kim Euibong Jemes, Bryan H. Norman, John R. Rizzo, Jeremy Schulenburg York, Kristina M. Campanale, Stefan Jon Thibodeaux, Richard E. Rathmell, Michael J. Hickey, Christopher Groshong, Shobha N. Bhattachar, Norman Earle Hughes, Anita K. Harvey, John G. Luz, Stephen Antonysamy, Scott Alan Jones, Timothy Andrew Woods, Prashant V. Desai, Matthew J. Fisher, Xiao-Peng Yu, Thomas W. Seng
Publikováno v:
Journal of Medicinal Chemistry. 59:194-205
As part of a program aimed at the discovery of antinociceptive therapy for inflammatory conditions, a screening hit was found to inhibit microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 17.4 μM. Structural information was used to impr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fa147abbccd68e15b02f28a0c1735a
https://doi.org/10.1021/acs.jmedchem.5b01249
https://doi.org/10.1021/acs.jmedchem.5b01249
Autor:
Matthew W. Carson, Robert J. Barr, Dana Sindelar, Daniel Timothy Kohlman, Bradley Condon, David K. Clawson, A. Pustilnik, M. Joelle Dill, James S. Bean, John G. Luz, Michael J. Coghlan, Milan Maletic
Publikováno v:
Journal of Medicinal Chemistry. 58:6607-6618
To further elucidate the structural activity correlation of glucocorticoid receptor (GR) antagonism, the crystal structure of the GR ligand-binding domain (GR LBD) complex with a nonsteroidal antagonist, compound 8, was determined. This novel indole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05523d9b3d43e70486cf70fa19d94a56
https://doi.org/10.1021/acs.jmedchem.5b00736
https://doi.org/10.1021/acs.jmedchem.5b00736
Autor:
Kuklish Steven Lee, Dagart Allison, Bradley Condon, Aiping Zhang, Anita K. Harvey, Ashley V. Sloan, Xiao-Peng Yu, Ryan Thomas Backer, Matthew R. Lee, John G. Luz, Marijane Russell, Srinivasan Chandrasekhar, Matthew Fisher, Shawn Chang, Stephen Antonysamy
Publikováno v:
Journal of Medicinal Chemistry. 58:4727-4737
Microsomal prostaglandin E synthase 1 (mPGES-1) is an α-helical homotrimeric integral membrane inducible enzyme that catalyzes the formation of prostaglandin E2 (PGE2) from prostaglandin H2 (PGH2). Inhibition of mPGES-1 has been proposed as a therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f51d736c36586dd49c583231b9633f
https://doi.org/10.1021/acs.jmedchem.5b00330
https://doi.org/10.1021/acs.jmedchem.5b00330
Autor:
Aiping Zhang, Yuewei Qian, Feiyu Zhang, Dagart Allison, Bradley Condon, Xun Zhao, James A. Jamison, Sheela Ashok, Tarun Gheyi, Marijane Russell, John G. Luz, Iain MacEwan
Publikováno v:
Journal of Medicinal Chemistry. 56:963-969
The sirtuin SIRT1 is a NAD(+)-dependent histone deacetylase, a Sir2 family member, and one of seven human sirtuins. Sirtuins are conserved from archaea to mammals and regulate transcription, genome stability, longevity, and metabolism. SIRT1 regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b78d0a61c4026702dc3228580a78fbc
https://doi.org/10.1021/jm301431y
https://doi.org/10.1021/jm301431y
Autor:
Mark D, Chappell, Renhua, Li, Stephon C, Smith, Bruce A, Dressman, Eric G, Tromiczak, Allie E, Tripp, Maria-Jesus, Blanco, Tatiana, Vetman, Steven J, Quimby, James, Matt, Thomas C, Britton, Adam M, Fivush, Jeffrey M, Schkeryantz, Daniel, Mayhugh, Jon A, Erickson, Mark G, Bures, Carlos, Jaramillo, Mercedes, Carpintero, José Eugenio de, Diego, Mario, Barberis, Susana, Garcia-Cerrada, José F, Soriano, Stephen, Antonysamy, Shane, Atwell, Iain, MacEwan, Bradley, Condon, Christine, Sougias, Jing, Wang, Aiping, Zhang, Kris, Conners, Chris, Groshong, Stephen R, Wasserman, John W, Koss, Jeffrey M, Witkin, Xia, Li, Carl, Overshiner, Keith A, Wafford, Wesley, Seidel, Xu-Shan, Wang, Beverly A, Heinz, Steven, Swanson, John T, Catlow, David W, Bedwell, James A, Monn, Charles H, Mitch, Paul L, Ornstein
Publikováno v:
Journal of medicinal chemistry. 59(24)
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5baf0617bc8dab1818e329dffd2bc0c6
https://pubmed.ncbi.nlm.nih.gov/28002967
https://pubmed.ncbi.nlm.nih.gov/28002967