The in vitro metabolism of sphingosine-1-phosphate: Identification; inhibition and pharmacological implications

Autor: Bradley, Michelle E., McGuinness, Neil, Williams, Gareth, Charlton, Steven J., Dowling, Mark R.

Publikováno v: In European Journal of Pharmacology 2011 672(1):56-61

Long receptor residence time of C26 contributes to super agonist activity at the human ?2 adrenoceptor

Autor: Rosethorne, Elizabeth M., Bradley, Michelle E., Gherbi, Karolina, Sykes, David A., Sattikar, Afrah, Wright, John D., Renard, Emilie, Trifilieff, A., Fairhurst, Robin A., Charlton, Steven J.

Super agonists produce greater functional responses than endogenous agonists in the same assay, and their unique pharmacology is the subject of increasing interest and debate. We propose that receptor residence time and the duration of receptor signa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::d03176e3bd556bd54734471bcf64bc52
https://nottingham-repository.worktribe.com/file/778040/1/MOLPHARM-2015-101253v2-Charlton.pdf

An investigation into the structure–activity relationships associated with the systematic modification of the β2-adrenoceptor agonist indacaterol

Autor: Beattie, David, Beer, David, Bradley, Michelle E., Bruce, Ian, Charlton, Steven J., Cuenoud, Bernard M., Fairhurst, Robin A., Farr, David, Fozard, John R., Janus, Diana, Rosethorne, Elizabeth M., Sandham, David A., Sykes, David A., Trifilieff, Alexandre, Turner, Katharine L., Wissler, Elke

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 1 October 2012 22(19):6280-6285

Long Receptor Residence Time of C26 Contributes to Super Agonist Activity at the Human β2Adrenoceptor

Autor: Rosethorne, Elizabeth M., Bradley, Michelle E., Gherbi, Karolina, Sykes, David A., Sattikar, Afrah, Wright, John D., Renard, Emilie, Trifilieff, Alex, Fairhurst, Robin A., Charlton, Steven J.

Publikováno v: Molecular Pharmacology; 2016, Vol. 89 Issue: 4 p467-475, 9p

Functional desensitization of the β 2 adrenoceptor is not dependent on agonist efficacy.

Autor: Rosethorne EM; Novartis Institutes for Biomedical Research Wimblehurst Road, Horsham, West Sussex, RH12 5AB, United Kingdom ; School of Life Sciences, Queen's Medical Centre, University of Nottingham Nottingham, NG7 2UH, United Kingdom., Bradley ME; Novartis Institutes for Biomedical Research Wimblehurst Road, Horsham, West Sussex, RH12 5AB, United Kingdom., Kent TC; Novartis Institutes for Biomedical Research Wimblehurst Road, Horsham, West Sussex, RH12 5AB, United Kingdom., Charlton SJ; Novartis Institutes for Biomedical Research Wimblehurst Road, Horsham, West Sussex, RH12 5AB, United Kingdom ; School of Life Sciences, Queen's Medical Centre, University of Nottingham Nottingham, NG7 2UH, United Kingdom.

Publikováno v: Pharmacology research & perspectives [Pharmacol Res Perspect] 2015 Feb; Vol. 3 (1), pp. e00101. Date of Electronic Publication: 2015 Jan 05.