Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Bradley, Class"'
Autor:
Kirill Gorshkov, Amy Q. Wang, Wei Sun, Ethan Fisher, Marta Frigeni, Marc Singleton, Natasha Thorne, Bradley Class, Wenwei Huang, Nicola Longo, Minh‐Ha T. Do, Elizabeth A. Ottinger, Xin Xu, Wei Zheng
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)
Abstract Creatine transporter deficiency (CTD) is a metabolic disorder resulting in cognitive, motor, and behavioral deficits. Cyclocreatine (cCr), a creatine analog, has been explored as a therapeutic strategy for the treatment of CTD. We developed
Externí odkaz:
https://doaj.org/article/5eae92316c67492782ecbd46078cdb8d
Autor:
Melanie Quintana, William A. Gahl, Levent Bayman, Scott A. Van Wart, Colleen Jodarski, Claire T. Driscoll, Chia-Ying Liu, Nuria Carrillo, Carla Ciccone, Galen O. Joe, Scott M. Berry, Rebecca Parks, John D. Heiss, Bradley Class, May Christine V. Malicdan, Kennan Bradley, Petcharat Leoyklang, Joseph A. Shrader, John Perreault, Christopher S. Coffey, Christina Slota, Marjan Huizing
Publikováno v:
Genetics in Medicine
BASE-Bielefeld Academic Search Engine
BASE-Bielefeld Academic Search Engine
PURPOSE To evaluate the safety and efficacy of N-acetylmannosamine (ManNAc) in GNE myopathy, a genetic muscle disease caused by deficiency of the rate-limiting enzyme in N-acetylneuraminic acid (Neu5Ac) biosynthesis. METHODS We conducted an open-labe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a82c0347e0a4ccd7fefea938b01afb7
http://europepmc.org/articles/PMC8553608
http://europepmc.org/articles/PMC8553608
Autor:
Aaron D. Gitler, Nicholas J. Brandon, Korrie L. Mack, Hana M. Odeh, Thomas A. Ollerhead, Bo Lim Lee, Stephen J. Moss, Bradley Class, Ashkan Javaherian, James Shorter, John Dunlop, Alice Flynn Ford, Mari Aikio, Steven Finkbeiner, Heike J. Wobst, Ryan R. Cupo, Lauren E. Drake, Dean G. Brown, Ashmita Baral, Nicholas A. Castello, Edward M. Barbieri
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder typically characterized by insoluble inclusions of hyperphosphorylated TDP-43. The mechanisms underlying toxic TDP-43 accumulation are not understood. Persistent activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61a033b9c4422f431aa9088ab9b0181b
https://doi.org/10.1101/2021.08.04.455154
https://doi.org/10.1101/2021.08.04.455154
Autor:
Sagar Lonial, Shambavi Richard, Jeffrey V Matous, Andrew J. Yee, Urvi Shah, Neha Mehta-Shah, Thomas Martin, Eli Muchtar, Sikander Ailawadhi, Paul G. Richardson, Manisha Bhutani, Samantha Perino, Jason Kirby, Roman V. Agafonov, Prasoon Chaturvedi, Bradley Class, Matthew Schnaderbeck, Michael R. Palmer, Cathleen Gorman, Oliver Schoenborn-Kellenberger, Amanda Hoerres, Stewart L. Fisher, Roy M. Pollock, Adam Crystal, Michelle Mahler, Jesus Bardeja
Publikováno v:
Cancer Research. 82:CT186-CT186
Introduction: CFT7455 is a highly potent and novel Ikaros Family Zinc Finger Protein 1/3 (IKZF1/3) degrader. In xenograft models, CFT7455 has more potent IKZF1/3 degradation compared to other degraders. Early observations from the FIH clinical trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaa6ccdd4c7c9fade620d29c185b7e4a
https://doi.org/10.1158/1538-7445.am2022-ct186
https://doi.org/10.1158/1538-7445.am2022-ct186
Autor:
James A. Henderson, Scott J. Eron, Andrew Good, R Jason Kirby, Samantha Perino, Roman V. Agafonov, Prasoon Chaturvedi, Bradley Class, David Cocozziello, Ashley A. Hart, Christina S. Henderson, Marta Isasa, Brendon Ladd, Matt Schnaderbeck, Michelle Mahler, Adam S. Crystal, Roy M. Pollock, Christopher G. Nasveschuk, Andrew J. Phillips, Stewart L. Fisher, David A. Proia
Publikováno v:
Cancer Research. 82:ND13-ND13
Introduction: Ikaros family zinc finger protein 1 and 3 (IKZF1/3) are essential transcription factors (TF) for terminal differentiation of B and T cells. Depletion of IKZF1/3 inhibits the growth of multiple myeloma (MM) cells, confirming their depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42186bfdcb13c3303d47d3055f7346ca
https://doi.org/10.1158/1538-7445.am2022-nd13
https://doi.org/10.1158/1538-7445.am2022-nd13
Autor:
Bradley Class, Yifan Shi, Xin Xu, Michael Zhang, Amy Wang, Wanjing Liu, William A. Gahl, Carla Ciccone, Meng Fang, Nuria Carrillo, Guodong Gu, Marjan Huizing
Publikováno v:
Biomed Chromatogr
The biosynthesis of sialic acid (Neu5Ac) leads to the intracellular production of cytidine-5'-monophospho-N-acetylneuraminic acid (CMP-Neu5Ac), the active sialic acid donor to nascent glycans (glycoproteins and glycolipids) in the Golgi. UDP-N-acetyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd4b4e9e0a206d4097559516d07d6c3
https://europepmc.org/articles/PMC8336284/
https://europepmc.org/articles/PMC8336284/
Autor:
Scott J. Eron, Roy M. Pollock, Adam S. Crystal, James A. Henderson, Prasoon Chaturvedi, Christina S. Henderson, Samantha Perino, Stewart L. Fisher, Matt Schnaderbeck, Marta Isasa, Ashley A. Hart, Christopher G. Nasveschuk, Andrew C. Good, Roman V. Agafonov, R. Jason Kirby, Bradley Class, David Cocozziello, Michelle Mahler, David A. Proia, Andrew J. K. Phillips, Brendon Ladd
Publikováno v:
Cancer Research. 81:LB007-LB007
Introduction Ikaros family zinc finger protein 1 and 3 (IKZF1/3) are essential transcription factors (TF) for terminal differentiation of B and T cells. Depletion of IKZF1/3 in MM cells inhibits growth, confirming their dependency on IKZF1/3. IMiDs (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aa2374fa57ec020d2e2ec7fb38e670b
https://doi.org/10.1158/1538-7445.am2021-lb007
https://doi.org/10.1158/1538-7445.am2021-lb007
Autor:
William A. Gahl, John D. Heiss, Vandana Singhal, Joseph A. Shrader, Angela Gruber, John Perreault, Prashant Chittiboina, Christina Slota, Aaron Poliak, Christina Hayes, Carla Ciccone, Marjan Huizing, May Christine V. Malicdan, Jennifer Garland, Joshi Stephen, Bradley Class, Ralitza H. Gavrilova, Galen O. Joe, Nuria Carrillo
Publikováno v:
Molecular Genetics & Genomic Medicine. 5:410-417
Background GNE myopathy is a rare genetic disease characterized by progressive muscle atrophy and weakness. It is caused by biallelic mutations in the GNE gene that encodes for the bifunctional enzyme, uridine diphosphate (UDP)-N-acetylglucosamine (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64c6152e6e474ac65f435d799e37663d
https://doi.org/10.1002/mgg3.300
https://doi.org/10.1002/mgg3.300
Autor:
Elizabeth A. Ottinger, Minh-Ha Do, Marc Singleton, Bradley Class, Kirill Gorshkov, Ethan G. Fisher, Nicola Longo, Wei Zheng, Wenwei Huang, Xin Xu, Wei Sun, Amy Wang, Natasha Thorne, Marta Frigeni
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives
Creatine transporter deficiency (CTD) is a metabolic disorder resulting in cognitive, motor, and behavioral deficits. Cyclocreatine (cCr), a creatine analog, has been explored as a therapeutic strategy for the treatment of CTD. We developed a rapid,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f7e7ac2f9d94eef29e9ecbc7a5091e
https://doi.org/10.1002/prp2.525
https://doi.org/10.1002/prp2.525
Autor:
Noel Southall, Jean Zhao, Natasha Thorne, Bradley Class, Wei Zheng, John C. McKew, Menghang Xia, Francis Aguisanda, Nasir Malik, Mahendra S. Rao, Sonia Shah
Publikováno v:
Stem Cells Translational Medicine
Using astrocytes differentiated from human embryonic stem cells, an assay was developed to identify compounds that protect against oxidative stress, a condition associated with many neurodegenerative diseases. The assay has been optimized for high-th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7790d3de8ae130ffdb7c8e8cf547dc
https://doi.org/10.5966/sctm.2015-0170
https://doi.org/10.5966/sctm.2015-0170