Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Bradford T. Stokes"'
Publikováno v:
Springer Series in Translational Stroke Research ISBN: 9783030160807
Springer Protocols Handbooks ISBN: 9781603271844
Springer Protocols Handbooks ISBN: 9781603271844
Approximately half of the clinical cases of spinal cord injury are caused by a rapid contusive impact to the soft tissue of the spinal cord. Reproducible models of contusion injury are produced in rodents using a variety of approaches following the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69608226de6c3c71e793a4a5496d5670
https://doi.org/10.1007/978-3-030-16082-1_30
https://doi.org/10.1007/978-3-030-16082-1_30
Publikováno v:
Neuroscience. 156:498-514
Spinal cord injury (SCI) in mammals leads to a robust inflammatory response followed by the formation of a glial and connective tissue scar that comprises a barrier to axonal regeneration. The inbred MRL/MpJ mouse strain exhibits reduced inflammation
Publikováno v:
The Journal of Neuroscience. 26:12537-12543
This study asked whether operant conditioning of the H-reflex can modify locomotion in spinal cord-injured rats. Midthoracic transection of the right lateral column of the spinal cord produced a persistent asymmetry in the muscle activity underlying
Autor:
Bradford T. Stokes, Jonathan R. Wolpaw, Xiang Yang Chen, Lyn B. Jakeman, Gerwin Schalk, Yi Chen
Publikováno v:
The Journal of Neuroscience. 25:6898-6906
New and old motor skills can interfere with each other or interact in other ways. Because each skill entails a distributed pattern of activity-dependent plasticity, investigation of their interactions is facilitated by simple models. In a well charac
Publikováno v:
Experimental Neurology. 163:220-230
Transforming growth factor-beta1 (TGFbeta1) is a cytokine/growth factor found within the pathological central nervous system. TGFbeta1 has been shown to inhibit the release of cytotoxic molecules from microglia and macrophages, decrease astrocyte pro
Autor:
Ravi Ponnappan, Roger Dzwonczyk, Bradford T. Stokes, Lyn B. Jakeman, Zhen Guan, Phillip G. Popovich, Ping Wei
Publikováno v:
Journal of Neurotrauma. 17:299-319
Previous work from this laboratory has described a rat spinal cord injury (SCI) model in which the mid-thoracic spinal cord is subjected to a single rapid and calibrated displacement at the site of a dorsal laminectomy. Injury is initiated at the tip
Publikováno v:
Annals of Neurology. 45:120-124
Peroxynitrite formation and the subsequent activation of the nuclear enzyme, poly (adenosine diphosphate [ADP]-ribose) synthetase (PARS), has been implicated in the pathogenesis of several neurodegenerative disorders. Here, we demonstrate that nitrot
Autor:
Joseph S. Ottobre, Brian K. Petroff, A. C. Ottobre, Zhen Guan, Bradford T. Stokes, Renata E. Ciereszko
Publikováno v:
Journal of Endocrinology. 159:201-209
Previously, we reported that administration of prolactin (PRL) during the early luteal phase in sows increases plasma progesterone concentrations. In the current study, we searched for the mechanisms by which PRL exerts this luteotrophic effect. The
Publikováno v:
Experimental Neurology. 154:170-184
Neurotrophic factors have been proposed as a therapeutic treatment for traumatic brain and spinal cord injury. The present study determined whether exogenous administration of one such factor, brain-derived neurotrophic factor (BDNF), could effect be
Publikováno v:
Brain Research. 802:175-183
Inhibition of the host's neutrophil response has been proposed as one means to reduce tissue damage in acute inflammation. If this approach can be applied in acute central nervous system (CNS) infection, the long-term morbidity, which occurs in CNS i