Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Bradford P. Smith"'
Autor:
Franziska Roeder, Tina Röpke, Lara-Kristin Steinmetz, Martin Kolb, Ulrich A. Maus, Bradford J. Smith, Lars Knudsen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Pre-injured lungs are prone to injury progression in response to mechanical ventilation. Heterogeneous ventilation due to (micro)atelectases imparts injurious strains on open alveoli (known as volutrauma). Hence, recruitment of (micro)atelec
Externí odkaz:
https://doaj.org/article/4cb35dbb795c4470a64393acdd535155
Autor:
Jordan N. Edwards, Madeline A. Whitney, Bradford B. Smith, Megan K. Fah, Skye A. Buckner Petty, Omar Durra, Kristen A. Sell-Dottin, Erica Portner, Erica D. Wittwer, Adam J. Milam
Publikováno v:
BJA Open, Vol 10, Iss , Pp 100270- (2024)
Background: This retrospective study evaluated the efficacy and safety of intraoperative methadone compared with short-acting opioids. Methods: Patients undergoing cardiac surgery with cardiopulmonary bypass (n=11 967) from 2018 to 2023 from a single
Externí odkaz:
https://doaj.org/article/5a0bda4e35ef44a9a5bd0cd195ed6062
Autor:
Drew C. Gottman, Bradford J. Smith
Publikováno v:
Frontiers in Network Physiology, Vol 4 (2024)
IntroductionAcute respiratory distress syndrome (ARDS) presents a significant clinical challenge, with ventilator-induced lung injury (VILI) being a critical complication arising from life-saving mechanical ventilation. Understanding the spatial and
Externí odkaz:
https://doaj.org/article/d5109a1c9ed1438d928fcc004bd6c333
Autor:
Jill Bilodeaux, Huda Farooqi, Maria Osovskaya, Alexander Sosa, Alison Wallbank, Lars Knudsen, Peter D. Sottile, David J. Albers, Bradford J. Smith
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Acute respiratory distress syndrome (ARDS) and acute lung injury have a diverse spectrum of causative factors including sepsis, aspiration of gastric contents, and near drowning. Clinical management of severe lung injury typically includes mechanical
Externí odkaz:
https://doaj.org/article/4aa53286308d41fd8f215c0715e85a9a
Autor:
Lars Knudsen, Benjamin Hummel, Christoph Wrede, Richard Zimmermann, Carrie E. Perlman, Bradford J. Smith
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Within the pulmonary acini ventilation and blood perfusion are brought together on a huge surface area separated by a very thin blood-gas barrier of tissue components to allow efficient gas exchange. During ventilation pulmonary acini are cyclically
Externí odkaz:
https://doaj.org/article/87b03e3306d446ac98a03f65e079eb69
Autor:
Ian T. Stancil, Jacob E. Michalski, Duncan Davis-Hall, Hong Wei Chu, Jin-Ah Park, Chelsea M. Magin, Ivana V. Yang, Bradford J. Smith, Evgenia Dobrinskikh, David A. Schwartz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Environmental and genetic risk factors affect the distal airway epithelium in idiopatic pulmonary fibrosis (IPF) but the role of the epithelium in IPF remains unclear. Here the authors show that pathologic activation of the ERBB-YAP axis induces dyna
Externí odkaz:
https://doaj.org/article/01dae7f647b5461cb308f23c36fac345
Publikováno v:
Annals of Thoracic Medicine, Vol 15, Iss 4, Pp 190-198 (2020)
Mortality associated with the acute respiratory distress syndrome remains unacceptably high due in part to ventilator-induced lung injury (VILI). Ventilator dyssynchrony is defined as the inappropriate timing and delivery of a mechanical breath in re
Externí odkaz:
https://doaj.org/article/ba217ec1fb934ec6a340524a4c90ca6c
Autor:
Alicia N. Rizzo, Sarah M. Haeger, Kaori Oshima, Yimu Yang, Alison M. Wallbank, Ying Jin, Marie Lettau, Lynda A. McCaig, Nancy E. Wickersham, J. Brennan McNeil, Igor Zakharevich, Sarah A. McMurtry, Christophe J. Langouët-Astrié, Katrina W. Kopf, Dennis R. Voelker, Kirk C. Hansen, Ciara M. Shaver, V. Eric Kerchberger, Ryan A. Peterson, Wolfgang M. Kuebler, Matthias Ochs, Ruud A.W. Veldhuizen, Bradford J. Smith, Lorraine B. Ware, Julie A. Bastarache, Eric P. Schmidt
Publikováno v:
JCI Insight, Vol 7, Iss 2 (2022)
Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure yet has few pharmacologic therapies, reflecting the mechanistic heterogeneity of lung injury. We hypothesized that damage to the alveolar epithelial glycocalyx, a lay
Externí odkaz:
https://doaj.org/article/31aa2a1550884c5a8f8b113a7914671a
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Motivated by a desire to understand pulmonary physiology, scientists have developed physiological lung models of varying complexity. However, pathophysiology and interactions between human lungs and ventilators, e.g., ventilator-induced lung injury (
Externí odkaz:
https://doaj.org/article/be8c600b0ca74b35a7748ebe6fa3df5a
Autor:
Erica W. Mandell, Courtney Mattson, Gregory Seedorf, Sharon Ryan, Tania Gonzalez, Alison Wallbank, Elisa M. Bye, Steven H. Abman, Bradford J. Smith
Publikováno v:
Frontiers in Physiology, Vol 11 (2021)
Perinatal inflammation due to chorioamnionitis and ventilator-induced lung injury (VILI) at birth is independent risk factors for the development of bronchopulmonary dysplasia (BPD). We have previously shown that antenatal endotoxin (ETX) causes abno
Externí odkaz:
https://doaj.org/article/c5bb541b066442d4917457edc6595d73