Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Bradford Graves"'
Autor:
Maureen Caligiuri, Grace L. Williams, Jennifer Castro, Linda Battalagine, Erik Wilker, Lili Yao, Shawn Schiller, Angela Toms, Ping Li, Eneida Pardo, Bradford Graves, Joey Azofeifa, Agustin Chicas, Torsten Herbertz, Maria Lai, Joel Basken, Kenneth W. Wood, Qunli Xu, Sylvie M. Guichard
Publikováno v:
Targeted Oncology. 18:269-285
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b83a4b5ffa700d6591f630c62f30ad00
https://doi.org/10.1007/s11523-023-00949-7
https://doi.org/10.1007/s11523-023-00949-7
Autor:
Kensuke Kojima, Gwen Nichols, Jianguo Zhi, Ruediger Rueger, Monica Reckner, Steve Middleton, Lori Jukofsky, Peter Bridge, Steven Blotner, Bradford Graves, Gong Chen, Xuelin Huang, Graciela M. Nogueras González, Vivian Ruvolo, Swaminathan Padmanabhan Iyer, Mark Kirschbaum, Paresh Vyas, Mark W. Drummond, Giovanni Martinelli, David Bowen, Leslie Popplewell, Roger Strair, Sarit Assouline, Karen Yee, Kevin R. Kelly, Michael Andreeff
The following information describes additional study design criteria and safety considerations used in the phase 1 clinical trial of RG7112 in patients with hematological malignancies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448e7208c04cf15744fde05f7fa0ec5d
https://doi.org/10.1158/1078-0432.22460697.v1
https://doi.org/10.1158/1078-0432.22460697.v1
Autor:
Kensuke Kojima, Gwen Nichols, Jianguo Zhi, Ruediger Rueger, Monica Reckner, Steve Middleton, Lori Jukofsky, Peter Bridge, Steven Blotner, Bradford Graves, Gong Chen, Xuelin Huang, Graciela M. Nogueras González, Vivian Ruvolo, Swaminathan Padmanabhan Iyer, Mark Kirschbaum, Paresh Vyas, Mark W. Drummond, Giovanni Martinelli, David Bowen, Leslie Popplewell, Roger Strair, Sarit Assouline, Karen Yee, Kevin R. Kelly, Michael Andreeff
Supplementary Fig. 1. Day 10 dose-mean PK profiles in patients with leukemia; Supplementary Figure 2. RG7112 induces p53-mediated apoptosis in circulating lymphoma cells from a patient with SLL/CLL (810 mg to 1500 mg BID)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ff90eadcc873d56ed29004c7759a71
https://doi.org/10.1158/1078-0432.22460700
https://doi.org/10.1158/1078-0432.22460700
Autor:
Kensuke Kojima, Gwen Nichols, Jianguo Zhi, Ruediger Rueger, Monica Reckner, Steve Middleton, Lori Jukofsky, Peter Bridge, Steven Blotner, Bradford Graves, Gong Chen, Xuelin Huang, Graciela M. Nogueras González, Vivian Ruvolo, Swaminathan Padmanabhan Iyer, Mark Kirschbaum, Paresh Vyas, Mark W. Drummond, Giovanni Martinelli, David Bowen, Leslie Popplewell, Roger Strair, Sarit Assouline, Karen Yee, Kevin R. Kelly, Michael Andreeff
Supplementary Table 1. Study stratification and dosing regimen; Supplementary Table 2. p53 target genes examined in this study; Supplementary Table 3. Characteristics of evaluable patients treated at the MTD; Supplementary Table 4. Patient demographi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f4cc19642954ea5217002d26030405
https://doi.org/10.1158/1078-0432.22460694.v1
https://doi.org/10.1158/1078-0432.22460694.v1
Autor:
Kensuke Kojima, Gwen Nichols, Jianguo Zhi, Ruediger Rueger, Monica Reckner, Steve Middleton, Lori Jukofsky, Peter Bridge, Steven Blotner, Bradford Graves, Gong Chen, Xuelin Huang, Graciela M. Nogueras González, Vivian Ruvolo, Swaminathan Padmanabhan Iyer, Mark Kirschbaum, Paresh Vyas, Mark W. Drummond, Giovanni Martinelli, David Bowen, Leslie Popplewell, Roger Strair, Sarit Assouline, Karen Yee, Kevin R. Kelly, Michael Andreeff
Purpose: RG7112 is a small-molecule MDM2 antagonist. MDM2 is a negative regulator of the tumor suppressor p53 and frequently overexpressed in leukemias. Thus, a phase I study of RG7112 in patients with hematologic malignancies was conducted.Experimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b8f506539b36aa97ffa998f3a1ed9f
https://doi.org/10.1158/1078-0432.c.6524571.v1
https://doi.org/10.1158/1078-0432.c.6524571.v1
Autor:
Lyubomir T. Vassilev, Binh Vu, Peter Wovkulich, Frank Podlaski, Michael Linn, Kwong-Him To, Kenneth Kolinsky, Edmund Lee, Rosario Garrido, Christine Tardell, Brian Higgins Mingxuan Xia, Zoran Filipovic, Kathryn Packman, Bradford Graves, Christian Tovar
PDF file - 71K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c1e12a2827bef15e4c7f52b8f26d01a
https://doi.org/10.1158/0008-5472.22398773.v1
https://doi.org/10.1158/0008-5472.22398773.v1
Autor:
Lyubomir T. Vassilev, Binh Vu, Peter Wovkulich, Frank Podlaski, Michael Linn, Kwong-Him To, Kenneth Kolinsky, Edmund Lee, Rosario Garrido, Christine Tardell, Brian Higgins Mingxuan Xia, Zoran Filipovic, Kathryn Packman, Bradford Graves, Christian Tovar
PDF file - 12K, Antitumor activity of RG7112 against a panel of solid tumor cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9c982ff418c10759c503fddf33cbb1
https://doi.org/10.1158/0008-5472.22398764.v1
https://doi.org/10.1158/0008-5472.22398764.v1
Autor:
Lyubomir T. Vassilev, Binh Vu, Peter Wovkulich, Frank Podlaski, Michael Linn, Kwong-Him To, Kenneth Kolinsky, Edmund Lee, Rosario Garrido, Christine Tardell, Brian Higgins Mingxuan Xia, Zoran Filipovic, Kathryn Packman, Bradford Graves, Christian Tovar
PDF file - 1272K, Comparison of MDM2 binding properties of RG7112 and nutlin-3a (S1); Overlay of the crystal structures of MDM2 bound to RG7112 and Nutlin-2 (S2); RG7112 is a non-genotoxic p53 activator (S3); Effect of RG7112 on the viability of HCT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed0ac5a589251b018ba5a026af7a98e
https://doi.org/10.1158/0008-5472.22398770
https://doi.org/10.1158/0008-5472.22398770
Autor:
Lyubomir T. Vassilev, Binh Vu, Peter Wovkulich, Frank Podlaski, Michael Linn, Kwong-Him To, Kenneth Kolinsky, Edmund Lee, Rosario Garrido, Christine Tardell, Brian Higgins Mingxuan Xia, Zoran Filipovic, Kathryn Packman, Bradford Graves, Christian Tovar
PDF file - 136K, Includes HTRF, cell growth/viability, apoptosis assays and biacore, crystal structure and animal studies. Also includes supplemental references.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462335161b3d3a7a48af64749143adb9
https://doi.org/10.1158/0008-5472.22398767.v1
https://doi.org/10.1158/0008-5472.22398767.v1
Autor:
Lyubomir T. Vassilev, Binh Vu, Peter Wovkulich, Frank Podlaski, Michael Linn, Kwong-Him To, Kenneth Kolinsky, Edmund Lee, Rosario Garrido, Christine Tardell, Brian Higgins Mingxuan Xia, Zoran Filipovic, Kathryn Packman, Bradford Graves, Christian Tovar
PDF file - 71K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8655381a5343939e61e7a77c7b97efe
https://doi.org/10.1158/0008-5472.22398773
https://doi.org/10.1158/0008-5472.22398773