O-GlcNAcylation Negatively Regulates Cardiomyogenic Fate in Adult Mouse Cardiac Mesenchymal Stromal Cells.

Autor: Ayesha Zafir, James A Bradley, Bethany W Long, Senthilkumar Muthusamy, Qianhong Li, Bradford G Hill, Marcin Wysoczynski, Sumanth D Prabhu, Aruni Bhatnagar, Roberto Bolli, Steven P Jones

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0142939 (2015)

In both preclinical and clinical studies, cell transplantation of several cell types is used to promote repair of damaged organs and tissues. Nevertheless, despite the widespread use of such strategies, there remains little understanding of how the e

Externí odkaz: https://doaj.org/article/9728094318db48c4a133d31ce8cad53b

Influence of biological sex and exercise on murine cardiac metabolism

Autor: Kyle Fulghum, Helen E. Collins, Steven P. Jones, Bradford G. Hill

Publikováno v: Journal of Sport and Health Science, Vol 11, Iss 4, Pp 479-494 (2022)

Although the structural and functional effects of exercise on the heart are well established, the metabolic changes that occur in the heart during and after exercise remain unclear. In this study, we used metabolomics to assess time-dependent changes

Externí odkaz: https://doaj.org/article/ded8e3ec23c94e9cbbfa5c79dc2f14f9

Exercise-induced specialized proresolving mediators stimulate AMPK phosphorylation to promote mitochondrial respiration in macrophages

Autor: Ernesto Pena Calderin, Jing-Juan Zheng, Nolan L. Boyd, Lindsey McNally, Timothy N. Audam, Pawel Lorkiewicz, Bradford G. Hill, Jason Hellmann

Publikováno v: Molecular Metabolism, Vol 66, Iss , Pp 101637- (2022)

Objective: Physical activity has been shown to reduce the risk of CVD mortality in large-cohort longitudinal studies; however, the mechanisms underpinning the beneficial effects of exercise remain incompletely understood. Emerging data suggest that t

Externí odkaz: https://doaj.org/article/83e0761586174192b1983211da9c826c

Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation

Autor: Alyssa A. Lombardi, Andrew A. Gibb, Ehtesham Arif, Devin W. Kolmetzky, Dhanendra Tomar, Timothy S. Luongo, Pooja Jadiya, Emma K. Murray, Pawel K. Lorkiewicz, György Hajnóczky, Elizabeth Murphy, Zoltan P. Arany, Daniel P. Kelly, Kenneth B. Margulies, Bradford G. Hill, John W. Elrod

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

Myofibroblast differentiation contributes to extracellular matrix remodeling and fibrosis. Here, the authors report that alterations in mitochondrial calcium uptake is essential for metabolic reprogramming and epigenetic signaling for activation of t

Externí odkaz: https://doaj.org/article/bdc7ccfd4f494ac28c7dce1cb6b33f83

Metabolic signatures of pregnancy-induced cardiac growth

Autor: Kyle L. Fulghum, Juliette B. Smith, Julia Chariker, Lauren F. Garrett, Kenneth R. Brittian, Pawel K. Lorkiewicz, Lindsey A. McNally, Shizuka Uchida, Steven P. Jones, Bradford G. Hill, Helen E. Collins

Publikováno v: Am J Physiol Heart Circ Physiol
Fulghum, K L, Smith, J B, Chariker, J, Garrett, L F, Brittian, K R, Lorkiewicz, P, McNally, L A, Uchida, S, Jones, S P, Hill, B G & Collins, H E 2022, ' Metabolic Signatures of Pregnancy-Induced Cardiac Growth ', American Journal of Physiology: Heart and Circulatory Physiology, vol. 323, no. 1, pp. H146-H164 . https://doi.org/10.1152/ajpheart.00105.2022

The goal of this study was to develop an atlas of the metabolic, transcriptional, and proteomic changes that occur with pregnancy in the maternal heart. Timed pregnancy studies in FVB/NJ mice revealed a significant increase in heart size by day 8 of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1758a83bc043dfdf36a85f3f2f5ea8c6
https://pubmed.ncbi.nlm.nih.gov/35622533