Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria

Autor: Melo-Gonzalez, F, Kammoun, H, Evren, E, Dutton, EE, Papadopoulou, M, Bradford, BM, Tanes, C, Fardus-Reid, F, Swann, JR, Bittinger, K, Mabbott, NA, Vallance, BA, Willinger, T, Withers, DR, Hepworth, MR

Publikováno v: Melo Gonzalez, F, Kammoun, H, Evren, E, Dutton, E E, Papadopoulou, M, Bradford, B M, Tanes, C, Fardus-Reid, F, Swann, J, Bittinger, K, Mabbott, N A, Vallance, B A, Willinger, T, Withers, D & Hepworth, M 2019, ' Antigen presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria ', Journal of Experimental Medicine, vol. 216, no. 4, pp. 728-742 . https://doi.org/10.1084/jem.20180871

Intestinal immune homeostasis is dependent upon tightly regulated and dynamic host interactions with the commensal microbiota. Immunoglobulin A (IgA) produced by mucosal B cells dictates the composition of commensal bacteria residing within the intes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f7f748707cf3a698fad145b95d2de9e0
https://eprints.soton.ac.uk/440861/

The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology.

Autor: Stables J; Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia; Robinson Research Institute, University of Adelaide, Adelaide, SA 5006, Australia., Pal R; The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK., Bradford BM; The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK., Carter-Cusack D; Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia., Taylor I; Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia., Pridans C; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK; Centre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh BioQuarter, Edinburgh EH16 4UU, UK., Khan N; School of Biomedical Sciences, The University of Queensland, St Lucia, QLD 4072, Australia., Woodruff TM; School of Biomedical Sciences, The University of Queensland, St Lucia, QLD 4072, Australia., Irvine KM; Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia., Summers KM; Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia., Mabbott NA; The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK., Hume DA; Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia. Electronic address: David.Hume@uq.edu.au.

Publikováno v: Neurobiology of disease [Neurobiol Dis] 2024 Nov 22; Vol. 203, pp. 106743. Date of Electronic Publication: 2024 Nov 22.

Microglia deficiency accelerates prion disease but does not enhance prion accumulation in the brain.

Autor: Bradford BM; The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush Campus, Midlothian, UK., McGuire LI; The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush Campus, Midlothian, UK., Hume DA; Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia., Pridans C; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, Edinburgh, UK.; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK., Mabbott NA; The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush Campus, Midlothian, UK.

Publikováno v: Glia [Glia] 2022 Nov; Vol. 70 (11), pp. 2169-2187. Date of Electronic Publication: 2022 Jul 19.

CNS macrophages differentially rely on an intronic Csf1r enhancer for their development.

Autor: Munro DAD; UK Dementia Research Institute at The University of Edinburgh, Chancellor's Building, Edinburgh EH16 4SB, UK., Bradford BM; The Roslin Institute & Royal (Dick) School of Veterinary Sciences, The University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK., Mariani SA; Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK., Hampton DW; Euan MacDonald Centre for MND Research, The University of Edinburgh, Edinburgh EH16 4SB, UK.; Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh EH16 4SB, UK., Vink CS; Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK., Chandran S; UK Dementia Research Institute at The University of Edinburgh, Chancellor's Building, Edinburgh EH16 4SB, UK.; Euan MacDonald Centre for MND Research, The University of Edinburgh, Edinburgh EH16 4SB, UK.; Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh EH16 4SB, UK.; Anne Rowling Regenerative Neurology Clinic, The University of Edinburgh, Edinburgh EH16 4SB, UK., Hume DA; Mater Research Institute, University of Queensland, Translational Research Institute, Woolloongabba Q4102, Australia., Pridans C; The University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK., Priller J; UK Dementia Research Institute at The University of Edinburgh, Chancellor's Building, Edinburgh EH16 4SB, UK josef.priller@ed.ac.uk.; Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh EH16 4SB, UK.; Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany.

Publikováno v: Development (Cambridge, England) [Development] 2020 Dec 15; Vol. 147 (23). Date of Electronic Publication: 2020 Dec 15.

The Effects of Immune System Modulation on Prion Disease Susceptibility and Pathogenesis.

Autor: Mabbott NA; The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK., Bradford BM; The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK., Pal R; The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK., Young R; The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK., Donaldson DS; The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2020 Oct 02; Vol. 21 (19). Date of Electronic Publication: 2020 Oct 02.