Zobrazeno 1 - 10
of 369
pro vyhledávání: '"Brad W Warner"'
Autor:
Emily J Onufer, Bola Aladegbami, Toru Imai, Kristen Seiler, Adam Bajinting, Cathleen Courtney, Stephanie Sutton, Aiza Bustos, Junjie Yao, Cheng-Hung Yeh, Anne Sescleifer, Lihong V Wang, Jun Guo, Brad W Warner
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0236964 (2020)
BackgroundShort bowel syndrome (SBS) results from significant loss of small intestinal length. In response to this loss, adaptation occurs, with Epidermal Growth Factor Receptor (EGFR) being a key driver. Besides enhanced enterocyte proliferation, we
Externí odkaz:
https://doaj.org/article/f0c162da93094ad695360c0e8b470eea
Autor:
Hongjian Qi, Lan Yu, Xueya Zhou, Julia Wynn, Haoquan Zhao, Yicheng Guo, Na Zhu, Alexander Kitaygorodsky, Rebecca Hernan, Gudrun Aspelund, Foong-Yen Lim, Timothy Crombleholme, Robert Cusick, Kenneth Azarow, Melissa E Danko, Dai Chung, Brad W Warner, George B Mychaliska, Douglas Potoka, Amy J Wagner, Mahmoud ElFiky, Jay M Wilson, Debbie Nickerson, Michael Bamshad, Frances A High, Mauro Longoni, Patricia K Donahoe, Wendy K Chung, Yufeng Shen
Publikováno v:
PLoS Genetics, Vol 14, Iss 12, p e1007822 (2018)
Congenital diaphragmatic hernia (CDH) is a severe birth defect that is often accompanied by other congenital anomalies. Previous exome sequencing studies for CDH have supported a role of de novo damaging variants but did not identify any recurrently
Externí odkaz:
https://doaj.org/article/5ee7f177ac4c4fcaa1154d035c69c6ac
Autor:
Yonghua He, Monica A Schmidt, Christopher Erwin, Jun Guo, Raphael Sun, Ken Pendarvis, Brad W Warner, Eliot M Herman
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157034 (2016)
Necrotizing enterocolitis (NEC) is a devastating condition of premature infants that results from the gut microbiome invading immature intestinal tissues. This results in a life-threatening disease that is frequently treated with the surgical removal
Externí odkaz:
https://doaj.org/article/740dfee25ed9458bbec4653d9e42bf8f
Autor:
Emily J. Onufer, Rafael S. Czepielewski, Yong-Hyun Han, Cathleen M. Courtney, Stephanie Sutton, Anne Sescleifer, Gwendalyn J. Randolph, Brad W. Warner
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Short bowel syndrome (SBS) is associated with diminished levels of serum fats caused by unknown mechanisms. We have shown that mesenteric lymphatics remodel to a more primitive state one week after small bowel resection (SBR); therefore, thi
Externí odkaz:
https://doaj.org/article/2e0a928a45014113a18801a719740391
Autor:
Hannah M. Phelps, Kerry A. Swanson, Allie E. Steinberger, Jun Guo, Ashley C. King, Chidananda Mudalagiriyappa Siddappa, Nicholas O. Davidson, Deborah C. Rubin, Brad W. Warner
Publikováno v:
Journal of Pediatric Surgery. 58:1170-1177
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1e99fb6d289ad4a40c3f34671a1851f
https://doi.org/10.1016/j.jpedsurg.2023.02.016
https://doi.org/10.1016/j.jpedsurg.2023.02.016
Autor:
Maria E. Tecos, Allie E. Steinberger, Jun Guo, Deborah C. Rubin, Nicholas O. Davidson, Brad W. Warner
Publikováno v:
Journal of Pediatric Surgery. 58:1074-1078
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::123b57ffe2f22aa0af9f42aba7dfde0e
https://doi.org/10.1016/j.jpedsurg.2023.02.031
https://doi.org/10.1016/j.jpedsurg.2023.02.031
Autor:
Kristen M. Seiler, Sarah E. Waye, Wenjun Kong, Kenji Kamimoto, Adam Bajinting, William H. Goo, Emily J. Onufer, Cathleen Courtney, Jun Guo, Brad W. Warner, Samantha A. Morris
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 3, Pp 407-426 (2019)
Background & Aims: The small intestine (SI) displays regionality in nutrient and immunological function. Following SI tissue loss (as occurs in short gut syndrome, or SGS), remaining SI must compensate, or “adapt”; the capacity of SI epithelium t
Externí odkaz:
https://doaj.org/article/f1b4e01318da43e0baba97df780a42b8
Autor:
Allie E. Steinberger, Maria E. Tecos, Hannah M. Phelps, Deborah C. Rubin, Nicholas O. Davidson, Jun Guo, Brad W. Warner
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 323:G165-G176
The unfolded protein response (UPR) is a complex adaptive signaling pathway activated by the accumulation of misfolded proteins in the endoplasmic reticulum (ER). ER stress (ERS) triggers a cascade of responses that converge upon C/EBP homologous pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f697dd63755a492a538e3c1a82c4cf9
https://doi.org/10.1152/ajpgi.00302.2021
https://doi.org/10.1152/ajpgi.00302.2021
Autor:
Lauren Barron, Raphael C. Sun, Bola Aladegbami, Christopher R. Erwin, Brad W. Warner, Jun Guo
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 2, Pp 231-244 (2017)
Background & Aims: Intestinal adaptation is a compensatory response to the massive loss of small intestine after surgical resection. We investigated the role of intestinal epithelial cellâspecific mammalian target of rapamycin complex 1 (i-mTORC1) i
Externí odkaz:
https://doaj.org/article/7cd195c41d034c5b8b9a831962beb272
Autor:
Brad W. Warner
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 4, Pp 429-438 (2016)
After massive small-bowel resection, the remnant bowel compensates by a process termed adaptation. Adaptation is characterized by villus elongation and crypt deepening, which increases the capacity for absorption and digestion per unit length. The me
Externí odkaz:
https://doaj.org/article/a778b582efae4ababc95aabf3aed22ec