Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Brad S. Rothberg"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Potassium channels such as MthK are presumed to have two allosterically coupled gates, the activation gate and the selectivity filter gate, that control gating transitions. Here authors use X-ray crystallography and molecular dynamics simulations on
Externí odkaz:
https://doaj.org/article/2439150ab6a24c11a4d33e924d7c0ef7
Publikováno v:
Non-Coding RNA, Vol 8, Iss 4, p 61 (2022)
The multikinase inhibitor, sorafenib, is a first-line treatment for hepatocellular carcinoma (HCC), but its limited efficacy, drug resistance and toxicity are a concern. In this study, we investigated the role of lncRNA TP53TG1 in the efficacy of sor
Externí odkaz:
https://doaj.org/article/39d9801afe23443895052ee6c53c4a2b
Autor:
Yandong Zhou, Xiangyu Cai, Natalia A. Loktionova, Xianming Wang, Robert M. Nwokonko, Xizhuo Wang, Youjun Wang, Brad S. Rothberg, Mohamed Trebak, Donald L. Gill
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
How plasma membrane Orai Ca2+ channels are activated by STIM proteins to activate Ca2+signals is still not fully known. Here the authors show that a nexus region located at the Orai1 C-terminus allows channel gating without a direct interaction of ST
Externí odkaz:
https://doaj.org/article/319437aa2a59462e85ad73d129f7e2ee
Autor:
Qian Guo, Mingyang Xin, Qingchun Lu, Dechun Feng, Vicky Yang, Lee F. Peng, Kelly A. Whelan, Wenhui Hu, Sheng Wu, Xiaofeng Yang, Hong Wang, Brad S. Rothberg, Ana M. Gamero, Glenn S. Gerhard, Bin Gao, Ling Yang
Publikováno v:
Theranostics. 13:2210-2225
K+channel activity can be limited by C-type inactivation, which is likely initiated in part by dissociation of K+ions from the selectivity filter, and modulated by side chains surrounding the selectivity filter. Whereas crystallographic and computati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d70f3374a487215b1d3c71851a6334d
https://doi.org/10.1101/2022.03.29.486236
https://doi.org/10.1101/2022.03.29.486236
Publikováno v:
Journal of General Physiology. 153
Large-conductance Ca2+-activated K+ (BK) channels control a range of physiological functions, and their dysfunction is linked to human disease. We have found that the widely used drug loperamide (LOP) can inhibit activity of BK channels composed of e
Autor:
Alexandre G. Vouga, Brad S. Rothberg
Publikováno v:
Biophysical Journal. 121:389a
Autor:
Brad S. Rothberg, Sebastian Brauchi
Publikováno v:
Cell Calcium
Novel structures of the human TRPA1 channel were determined in the presence of the agonist iodoacetamide and the antagonist A-967079, to reveal the open and closed states of the channel, respectively. The structures further revealed the location of C
Autor:
Merritt Maduke, Brad S. Rothberg
Publikováno v:
The Journal of General Physiology
The June issue of JPG is a collection of peer-reviewed articles contributed by participants of the very special Society of General Physiologists (SGP) 73rd Annual Symposium, hosted jointly with the Society of Latin American Biophysicists (SOBLA).
Publikováno v:
The Journal of General Physiology
Polyamines regulate K+ efflux from cells by binding to K channels in a voltage-dependent manner. Suma et al. analyze how two polyamines, spermidine and spermine, bind and block the prokaryotic K channel MthK.
Polyamines such as spermidine and sp
Polyamines such as spermidine and sp