Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Brad Roadcap"'
Autor:
Jia Yao Phuah, Brian M. Maas, Aimin Tang, Ying Zhang, Luzelena Caro, Radha A. Railkar, Michael D. Swanson, Yu Cao, Hankun Li, Brad Roadcap, Andrew P. Catchpole, Antonios O. Aliprantis, Kalpit A. Vora
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 169, Iss , Pp 115851- (2023)
Background: Clesrovimab (MK-1654) is an investigational, half-life extended human monoclonal antibody (mAb) against RSV F glycoprotein in clinical trials as a prophylactic agent against RSV infection for infants. Methods: This adult study measured cl
Externí odkaz:
https://doaj.org/article/6074672de6f4415ab83703ee8e9116c9
Autor:
Brian M. Maas, Jos Lommerse, Nele Plock, Radha A. Railkar, S.Y. Amy Cheung, Luzelena Caro, Jingxian Chen, Wen Liu, Ying Zhang, Qinlei Huang, Wei Gao, Li Qin, Jie Meng, Han Witjes, Emilie Schindler, Benjamin Guiastrennec, Francesco Bellanti, Daniel S. Spellman, Brad Roadcap, Mariya Kalinova, Juin Fok-Seang, Andrew P. Catchpole, Amy S. Espeseth, S. Aubrey Stoch, Eseng Lai, Kalpit A. Vora, Antonios O. Aliprantis, Jeffrey R. Sachs
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103651- (2021)
Background: Neutralizing mAbs can prevent communicable viral diseases. MK-1654 is a respiratory syncytial virus (RSV) F glycoprotein neutralizing monoclonal antibody (mAb) under development to prevent RSV infection in infants. Development and validat
Externí odkaz:
https://doaj.org/article/29110f874edd46dea00e331b42ac8484
Autor:
Keynu Carter, Neal Dube, Brad Roadcap, Dan Dreyer, Kevin P. Bateman, Azher Hussain, Yang Xu, Eric Woolf, Melanie Anderson, Faye Vazvaei, Erwin Berthier
Publikováno v:
Bioanalysis. 12:893-904
In this paper we show the application of the Tasso OnDemand™, a novel automated sample collection device, in conjunction with volumetric absorptive microsampling (VAMS) for the development of gefapixant, a P2X3 receptor antagonist currently under c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e76f3bb389f4b5f0ed158d3189868a1
https://doi.org/10.4155/bio-2020-0074
https://doi.org/10.4155/bio-2020-0074
Autor:
Melanie Anderson, Marissa F. Dockendorf, Ian McIntosh, Iris Xie, Sheila Breidinger, Dongfang Meng, Sumei Ren, Wendy Zhong, Li Zhang, Brad Roadcap, Kevin P. Bateman, Julie Stone, Eric Woolf
Publikováno v:
The AAPS journal. 24(3)
In-clinic dried blood spot (DBS) pharmacokinetic (PK) sampling was incorporated into two phase 3 studies of verubecestat for Alzheimer's disease (EPOCH [NCT01739348] and APECS [NCT01953601]), as a potential alternative to plasma PK sampling for impro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9bad4945abc142c531362a5beacaea
https://pubmed.ncbi.nlm.nih.gov/35384529
https://pubmed.ncbi.nlm.nih.gov/35384529
Publikováno v:
Bioanalysis. 11:1495-1508
Aim: A method to quantitate doravirine (MK-1439) in human plasma has been developed to support human clinical trials designed to evaluate the safety, pharmacokinetics and efficacy of the compound. Methodology & results: The analyte was extracted usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb96e7ad4351aa066250599ccf71cb3
https://doi.org/10.4155/bio-2019-0116
https://doi.org/10.4155/bio-2019-0116
Autor:
Naoto Uemura, Amitava Mitra, Kimberly Manser, Brad Roadcap, Aquiles E. Leyes, Christine Mestre, Lan Jin, Daniel Tatosian
Publikováno v:
Journal of Pharmaceutical Sciences. 104:1701-1708
In vitro cadaver skin permeation studies are often conducted to characterize the permeation profile of compounds for dermal delivery. However, its utility could be limited in the case of topical products because of lack of reliable prediction of in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53515eb757dcb544e3fb32a6494e322
https://doi.org/10.1002/jps.24383
https://doi.org/10.1002/jps.24383
Autor:
Arthur J. Bergman, John A. Wagner, James Dru, Brad Roadcap, Rajesh Krishna, Josee Cote, Eva Vets, Rita Chiou, Amit Garg, Regina W. Wang, Bo Jin, Varsha Didolkar, T Laethem, Keith Gottesdiener
Publikováno v:
The Journal of Clinical Pharmacology. 49:80-87
In this study, midazolam was used as a probe-sensitive CYP3A substrate to investigate the effect of anacetrapib on CYP3A activity, and ketoconazole was used as a probe-inhibitor to investigate the effect of potent CYP3A inhibition on the pharmacokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6a24676d16f80623019d1daa4c92dd
https://doi.org/10.1177/0091270008326718
https://doi.org/10.1177/0091270008326718
Autor:
Jamie J. Zhao, Paul G. Pearson, Bennett Ma, Brad Roadcap, Lida Liu, Jiunn H. Lin, Yue Qiu, Cuyue Tang, Thomas A. Baillie, Thomayant Prueksaritanont
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 301:1042-1051
A series of studies were conducted to explore the mechanism of the pharmacokinetic interaction between simvastatin (SV) and gemfibrozil (GFZ) reported recently in human subjects. After administration of a single dose of SV (4 mg/kg p.o.) to dogs pret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54538ab903e0886abb7a5c2419b2cc4
https://doi.org/10.1124/jpet.301.3.1042
https://doi.org/10.1124/jpet.301.3.1042
Autor:
Kenneth C. Lasseter, K Gottesdiener, L Liu, Amy O. Johnson-Levonas, Robert Valesky, A Laurent, Elizabeth Migoya, G Murphy, David Hreniuk, Brad Roadcap, N Matthews, Bingming Yi, John F. Paolini, Donald G. Musson, Arthur J. Bergman, J Gambale, Jamie J. Zhao, M Groff, Teddy Kosoglou, K Riffel, Paul Statkevich
Publikováno v:
International journal of clinical pharmacology and therapeutics. 44(2)
Objective: To assess the bioequivalence of an ezetimibe/simvastatin (EZE/SIMVA) combination tablet compared to the coadministration of ezetimibe and simvastatin as separate tablets (EZE + SIMVA). Methods: In this open-label, randomized, 2-part, 2-per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1ee683f2bcf674ddd1e95bf73d58d2
https://pubmed.ncbi.nlm.nih.gov/16502768
https://pubmed.ncbi.nlm.nih.gov/16502768
Autor:
Li Sun, Andrea Maes, Bart Keymeulen, John A. Wagner, Brad Roadcap, Amy Y. Yang, Jamie J. Zhao, Arthur J. Bergman, Josee Cote, Robert Valesky
Publikováno v:
Clinical Pharmacology & Therapeutics. 79:P48-P48
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9b5113622c1e7e321736bf93bad1105
https://doi.org/10.1016/j.clpt.2005.12.171
https://doi.org/10.1016/j.clpt.2005.12.171