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Akademický článek

Quantitative Comparison of the Sensitivity of Detection of Fluorescent and Bioluminescent Reporters in Animal Models

Autor: Tamara Troy, Dragana Jekic-McMullen, Lidia Sambucetti, Brad Rice

Publikováno v: Molecular Imaging, Vol 3 (2004)

Bioluminescent and fluorescent reporters are finding increased use in optical molecular imaging in small animals. In the work presented here, issues related to the sensitivity of in vivo detection are examined for standard reporters. A high-sensitivi

Externí odkaz: https://doaj.org/article/e790937602494046a5c62d8d1dacd885

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Data from Preclinical Validation of the Utility of BLZ-100 in Providing Fluorescence Contrast for Imaging Spontaneous Solid Tumors

Autor: Julia Parrish-Novak, Brad Rice, James M. Olson, Jeffrey Meganck, Sue E. Knoblaugh, Joshua I. Molho, Mark R. Stroud, Valorie Wiss, Stacey Hansen, William S. Dernell, Katie C. Kennedy, Janean Fidel

There is a need in surgical oncology for contrast agents that can enable real-time intraoperative visualization of solid tumors that can enable complete resections while sparing normal surrounding tissues. The Tumor Paint agent BLZ-100 is a peptide�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0412b89d72642e5b69b08609cf75e482
https://doi.org/10.1158/0008-5472.c.6507371.v1

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Supplemental Figure S2 from Preclinical Validation of the Utility of BLZ-100 in Providing Fluorescence Contrast for Imaging Spontaneous Solid Tumors

ROI analysis of ex vivo and in situ tumor and normal tissues.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f91d057daf657ad8fbc30f8d8c4485c
https://doi.org/10.1158/0008-5472.22407734

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Supplemental Figure Legends from Preclinical Validation of the Utility of BLZ-100 in Providing Fluorescence Contrast for Imaging Spontaneous Solid Tumors

Figure legends to accompany Supplemental Figure S1 and Supplemental Figure S2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100c2d2fb29ee7d6650da1208636b8c9
https://doi.org/10.1158/0008-5472.22407743

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Preclinical Validation of the Utility of BLZ-100 in Providing Fluorescence Contrast for Imaging Spontaneous Solid Tumors

Autor: Brad Rice, Janean Fidel, Stacey Hansen, Joshua I. Molho, Jeffrey A. Meganck, Valorie R. Wiss, Sue E. Knoblaugh, Katie C. Kennedy, James M. Olson, William S. Dernell, Mark R. Stroud, Julia Parrish-Novak

Publikováno v: Cancer Research. 75:4283-4291

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930a187a6d253289fb2130b1cb02928c
https://doi.org/10.1158/0008-5472.can-15-0471

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Adaptive Algebraic Reconstruction Technique Optimized for Fast Robust Bio-luminescence Tomography: Optical/CT Dual Modality In vivo Studies

Autor: Ali Behrooz, Brad Rice, Chaincy Kuo, Heng Xu

Publikováno v: Biomedical Optics and 3-D Imaging.

An optimized adaptive algebraic reconstruction technique for fast robust 3D bio-luminescence tomography is presented. Speed and performance of the algorithm in depth and flux quantification are examined by in silico, phantom and in vivo studies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9866207530b1d67d7b4566d86eb66dce
https://doi.org/10.1364/biomed.2012.btu3a.35

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Small animal optical multispectral Cerenkov tomography

Autor: Brad Rice, Chaincy Kuo, Antonello E. Spinelli, Federico Boschi, Andrea Sbarbati, Riccardo Calandrino, Pasquina Marzola

Publikováno v: 2011 IEEE Nuclear Science Symposium Conference Record.

A novel pre-clinical imaging modality called Cerenkov luminescence imaging (CLI) has been recently introduced for small animals in vivo imaging. CLI is based on the detection of optical Cerenkov radiation generated by beta particles as they travel in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496070ed839cc6ffb42d2206501f847e
https://doi.org/10.1109/nssmic.2011.6152495

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Bayesian Techniques in Fluorescence Tomography

Autor: Brad Rice, Chaincy Kuo

Publikováno v: Biomedical Optics.

Fluorescence tomography problems can be ill-posed, particularly when background fluorescence is high. We propose methods to improve robustness and present a new algorithm which reduces the intensity of artifacts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c7ef7820d2775e86a4acef2b9da9b29
https://doi.org/10.1364/biomed.2008.bsue46

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Improved sensitivity by applying spectral unmixing prior to fluorescent tomography

Autor: Chaincy Kuo, Heng Xu, Brad Rice

Publikováno v: Biomedical Optics.

Spectral unmixing technique was applied to the fluorescent tomography data acquired at multiple wavelengths to reduce the unwanted fluorophore signals and significantly improved the sensitivity and localization of the target fluorophore.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41d00b0bd205fb4f433e7555be84dfba
https://doi.org/10.1364/biomed.2008.bmc1

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In vivo bioluminescence tomography using multi-spectral and multiple-perspective image data

Autor: Ning Zhang, John J. Hunter, Chaincy Kuo, Haroon Ahsan, Brad Rice, Tamara L. Troy, Heng Xu

Publikováno v: Biomedical Optics.

A diffuse bioluminescent tomographic algorithm is validated with a tissue phantom, and in vivo experiments in which calibrated sources are implanted within living tissue. Longitudinal metastasis animal model data are analyzed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d735758d63d05d08c7c4df651d23bec
https://doi.org/10.1364/bio.2006.tug4

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