Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Brad R Henke"'
Autor:
Ryan E Feaver, M Scott Bowers, Banumathi K Cole, Steve Hoang, Mark J Lawson, Justin Taylor, Brian D LaMoreaux, Lin Zhao, Brad R Henke, Brian A Johns, Andrew C Nyborg, Brian R Wamhoff, Robert A Figler
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0291330 (2023)
Some health concerns are often not identified until late into clinical development of drugs, which can place participants and patients at significant risk. For example, the United States Food and Drug Administration (FDA) labeled the xanthine oxidase
Externí odkaz:
https://doaj.org/article/73653be581c742099685677071b70e9b
Autor:
Brian A. Johns, Christin A. Hamilton, Allison J. Armstrong, Robert A. Figler, Maria Sol Collado, Taylor D. Pourtaheri, Brad R. Henke, Marshall M. Summar, Stephen A. Hoang, Kimberly A. Chapman, John E. Reardon, Brian R. Wamhoff, Matthew W. Olson
Publikováno v:
Mol Genet Metab
Propionic Acidemia (PA) and Methylmalonic Acidemia (MMA) are inborn errors of metabolism affecting the catabolism of valine, isoleucine, methionine, threonine and odd-chain fatty acids. These are multi-organ disorders caused by the enzymatic deficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2d2bba59a2136c64aeca4cb4d67b68
https://doi.org/10.1016/j.ymgme.2021.03.001
https://doi.org/10.1016/j.ymgme.2021.03.001
Autor:
Brad R. Henke, Bonnie L. Bassler, Isabelle R. Taylor, Chari D. Smith, Philip D. Jeffrey, Jon E. Paczkowski
Publikováno v:
ACS Chemical Biology. 16:740-752
Pseudomonas aeruginosa is an opportunistic human pathogen that causes fatal infections. There exists an urgent need for new antimicrobial agents to combat P. aeruginosa. We conducted a screen for molecules that bind the virulence-controlling protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adb192282074294cf6f86a5cbed653f7
https://doi.org/10.1021/acschembio.1c00049
https://doi.org/10.1021/acschembio.1c00049
Autor:
Brad R. Henke, Jianping Cong, Bonnie L. Bassler, Justin E. Silpe, Jon E. Paczkowski, Olivia P. Duddy, Xiuliang Huang
Publikováno v:
J Biol Chem
Quorum sensing is a bacterial communication process whereby bacteria produce, release, and detect extracellular signaling molecules called autoinducers to coordinate collective behaviors. In the pathogen Vibrio cholerae, the quorum-sensing autoinduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41eb8066fb4e32824eb84e1b63136d8
https://doi.org/10.1074/jbc.ra119.012104
https://doi.org/10.1074/jbc.ra119.012104
Autor:
Isabelle R. Taylor, Bonnie L. Bassler, Brad R. Henke, Julie S Valastyan, Graham A B Hone, Michael R Tota, Chari D. Smith, Kenneth G Carson, Vasiliki Stergioula
Publikováno v:
ACS Chemical Biology. 15:446-456
Pseudomonas aeruginosa is a leading cause of hospital-acquired infections in the United States. PqsE, a thioesterase enzyme, is vital for virulence of P. aeruginosa, making PqsE an attractive target for inhibition. Neither the substrate nor the produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec0df9c377fa8448e1502c59d2f79b6a
https://doi.org/10.1021/acschembio.9b00905
https://doi.org/10.1021/acschembio.9b00905
Publikováno v:
Proceedings of the National Academy of Sciences. 116:245-254
Quorum sensing is a cell–cell communication process that bacteria use to orchestrate group behaviors. Quorum sensing is mediated by signal molecules called autoinducers. Autoinducers are often structurally similar, raising questions concerning how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6388079e4c0c2ab3abf8b25d172410a6
https://doi.org/10.1073/pnas.1817239116
https://doi.org/10.1073/pnas.1817239116
Autor:
John E Dillberger, Thomas D Roper, Allison J. Armstrong, Brian R. Wamhoff, Stephen A. Hoang, Matthew W. Olson, Justin M. Taylor, Brad R. Henke, John E. Reardon, Maria Sol Collado, Brian A. Johns, Robert A. Figler, Taylor D. Pourtaheri
Publikováno v:
Journal of medicinal chemistry. 64(8)
Propionic acidemia (PA) and methylmalonic acidemia (MMA) are rare autosomal recessive disorders of propionyl-CoA (P-CoA) catabolism, caused by a deficiency in the enzymes P-CoA carboxylase and methylmalonyl-CoA (M-CoA) mutase, respectively. PA and MM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254da545beecc6f429bfbe4bad4afc4f
https://pubmed.ncbi.nlm.nih.gov/33848153
https://pubmed.ncbi.nlm.nih.gov/33848153
Autor:
Isabelle R, Taylor, Jon E, Paczkowski, Philip D, Jeffrey, Brad R, Henke, Chari D, Smith, Bonnie L, Bassler
Publikováno v:
ACS Chemical Biology
Pseudomonas aeruginosa is an opportunistic human pathogen that causes fatal infections. There exists an urgent need for new antimicrobial agents to combat P. aeruginosa. We conducted a screen for molecules that bind the virulence-controlling protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d60e002bcd6a8b015d0fe16714638075
https://pubmed.ncbi.nlm.nih.gov/33793200
https://pubmed.ncbi.nlm.nih.gov/33793200
Autor:
Julie S, Valastyan, Michael R, Tota, Isabelle R, Taylor, Vasiliki, Stergioula, Graham A B, Hone, Chari D, Smith, Brad R, Henke, Kenneth G, Carson, Bonnie L, Bassler
Publikováno v:
ACS Chem Biol
Pseudomonas aeruginosa is a leading cause of hospital-acquired infections in the United States. PqsE, a thioesterase enzyme, is vital for virulence of P. aeruginosa, making PqsE an attractive target for inhibition. Neither the substrate nor the produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c0a269e6ad13ba641c509da936eed13
https://pubmed.ncbi.nlm.nih.gov/31880429
https://pubmed.ncbi.nlm.nih.gov/31880429
Autor:
Brad R. Henke, Eugene L. Stewart, John C. Ulrich, Curt D. Haffner, J. Darren Stuart, David N. Deaton, Barry G. Shearer, Michael R. Jeune
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:2107-2150
Starting from 4-amino-8-quinoline carboxamide lead 1a and scaffold hopping to the chemically more tractable quinazoline, a systematic exploration of the 2-substituents of the quinazoline ring, utilizing structure activity relationships and conformati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4fe7d9fc18b7c59f1ff4036d5152e6c
https://doi.org/10.1016/j.bmc.2018.03.021
https://doi.org/10.1016/j.bmc.2018.03.021