Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Brad P Hirakawa"'
Autor:
Shannon E. Leggieri, William A. Elyea, Matthew J. Nemec, Ellen Mihaich, Brad P. Hirakawa, Do Hyung Kim, Ann de Peyster
Publikováno v:
Toxicology. 319:23-37
Methyl tertiary-butyl ether (MTBE) is a solvent and fuel additive included in reformulated gasoline to increase combustion efficiency. While widespread use in motor fuels in the U.S. was discontinued after MTBE was detected in surface and ground wate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129e5476a55f9d513c58ba000c2abd43
https://doi.org/10.1016/j.tox.2014.01.015
https://doi.org/10.1016/j.tox.2014.01.015
Autor:
Eric L. Reyner, Caroline A. Lee, Harma Ellens, Kirsten M Mease, Cory A Watson, Rucha S. Sane, Liangfu Chen, Mitchell E. Taub, Márton Jani, Brad P Hirakawa
Publikováno v:
Drug Metabolism and Disposition. 39:2093-2102
Digoxin, an orally administered cardiac glycoside cardiovascular drug, has a narrow therapeutic window. Circulating digoxin levels (maximal concentration of ∼1.5 ng/ml) require careful monitoring, and the potential for drug-drug interactions (DDI)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb255ff616c4c03a727fc8dda083f781
https://doi.org/10.1124/dmd.111.040816
https://doi.org/10.1124/dmd.111.040816
Autor:
Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
Publikováno v:
Journal of Medicinal Chemistry. 48:6779-6782
A series of oxamyl dipeptides were optimized for pan caspase inhibition, anti-apoptotic cellular activity and in vivo efficacy. This structure-activity relationship study focused on the P4 oxamides and warhead moieties. Primarily on the basis of in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc05f6b9f812322c1ff557485178cfdb
https://doi.org/10.1021/jm050307e
https://doi.org/10.1021/jm050307e
Autor:
Niel C. Hoglen, Patricia C. Contreras, Brad P. Hirakawa, Long-Shiuh Chen, Todd Groessl, Craig D. Fisher
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 309:634-640
The potency, efficacy, and pharmacokinetic properties of IDN-6556 (3-[2-[(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid), a first-in-class caspase inhibitor in clinical trials for the trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cd6072fda815132c80b024022dc888
https://doi.org/10.1124/jpet.103.062034
https://doi.org/10.1124/jpet.103.062034
Autor:
Karen L. Valentino, Niel C. Hoglen, Craig D. Fisher, Patricia C. Contreras, Brad P. Hirakawa, David Shapiro
Publikováno v:
Hepatology. 38:579-579
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29b3360dc7096cd3aaa9385b4e55b45c
https://doi.org/10.1016/s0270-9139(03)80913-8
https://doi.org/10.1016/s0270-9139(03)80913-8