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A strategy to accelerate protein production from a pool of clones in Chinese hamster ovary cells for toxicology studies

Autor: John C. Joly, Zhilan Hu, Donna Quicho, Wendy Hsu, Michael W. Laird, Amy Shen, Domingos Ng, Zephie Kwong, Bradley R. Snedecor, Dana C. Andersen, Brad Mauger, Abby Pynn, Yilma T. Adem

Publikováno v: Biotechnology Progress. 33:1449-1455

In the biopharmaceutical industry, a clonally derived cell line is typically used to generate material for investigational new drug (IND)-enabling toxicology studies. The same cell line is then used to generate material for clinical studies. If a poo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ac2407be4987e86be0fa171b204b0f
https://doi.org/10.1002/btpr.2467

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Identification of a single base-pair mutation of TAA (Stop codon) → GAA (Glu) that causes light chain extension in a CHO cell derived IgG1

Autor: Tony Romeo, Scott Chamberlain, Taylor Zhang, Yung-Hsiang Kao, Brad Mauger, Viswanatham Katta, Mary Zhu, Judith Zhu-Shimoni, Daniel P. Hewitt, Yungfu Huang

Publikováno v: mAbs

We describe here the identification of a stop codon TAA (Stop) → GAA (Glu) = Stop221E mutation on the light chain of a recombinant IgG1 antibody expressed in a Chinese hamster ovary (CHO) cell line. The extended light chain variants, which were cau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b14256d94ba2e5c72e4965f6875959
https://pubmed.ncbi.nlm.nih.gov/23018810

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