Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Brad J. Schmier"'
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102658- (2023)
8-oxoA, a major oxidation product of adenosine, is a mispairing, mutagenic lesion that arises in DNA and RNA when •OH radicals or one-electron oxidants attack the C8 adenine atom or polymerases misincorporate 8-oxo(d)ATP. The danger of 8-oxoA is un
Externí odkaz:
https://doaj.org/article/5af356c9a0a24792b2236ee8a98f7221
Autor:
Brad J. Schmier, Stewart Shuman
Publikováno v:
Journal of Bacteriology. 200
5'- and 3'-end healing are key steps in nucleic acid break repair in which 5'-OH and 3'-PO4 or 2',3'-cyclic-PO4 ends are converted to 5'-PO4 and 3'-OH termini suitable for sealing by polynucleotide ligases. Here, we characterize Deinococcus radiodura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9394ec49c6f3a802e8553a1182aea7b8
https://doi.org/10.1128/jb.00151-18
https://doi.org/10.1128/jb.00151-18
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
NanoRNAs are RNA fragments 2 to 5 nucleotides in length that are generated as byproducts of RNA degradation and abortive transcription initiation. Cells have specialized enzymes to degrade nanoRNAs, such as the DHH phosphoesterase family member NanoR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cac57055930a149c776f489cb8eadc
https://doi.org/10.1038/s41598-017-09403-x
https://doi.org/10.1038/s41598-017-09403-x
Autor:
Stewart Shuman, Brad J. Schmier
Publikováno v:
Journal of Bacteriology. 196:1704-1712
Deinococcus radiodurans RNA ligase (DraRnl) is the founding member of a family of end-joining enzymes encoded by diverse microbes and viruses. DraRnl ligates 3′-OH, 5′-PO 4 nicks in double-stranded nucleic acids in which the nick 3′-OH end is R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23cfb1a34d3896c7176353228a97cbd
https://doi.org/10.1128/jb.00020-14
https://doi.org/10.1128/jb.00020-14
Publikováno v:
Journal of Molecular Biology. 415:547-559
Exoribonucleases are vital in nearly all aspects of RNA metabolism, including RNA maturation, end-turnover, and degradation. RNase II and RNase R are paralogous members of the RNR superfamily of nonspecific, 3′ → 5′, processive exoribonucleases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a82d7a2cfce9f5f80f61ef22ad400e
https://doi.org/10.1016/j.jmb.2011.11.031
https://doi.org/10.1016/j.jmb.2011.11.031
Publikováno v:
Biochemistry & Analytical Biochemistry.
Porphyromonas gingivalis is an oral pathogenic bacterium that causes halitosis (bad breath) and periodontitis in humans. Halitosis manifests due to volatile sulfur compounds such as methylthiol, generated from methionine degradation by Methionine Gam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c4a6902ed5713ed7910763fd263c9cc
https://doi.org/10.4172/2161-1009.1000223
https://doi.org/10.4172/2161-1009.1000223
Publikováno v:
Nucleic Acids Research
Deinococcus radiodurans RNA ligase (DraRnl) seals 3΄-OH/5΄-PO4 nicks in duplex nucleic acids in which the 3΄-OH nick terminus consists of two or more ribonucleotides. DraRnl exemplifies a widely distributed Rnl5 family of nick-sealing RNA ligases,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd85766e9ee18e4b982dc24bfae45feb
https://doi.org/10.1093/nar/gkx038
https://doi.org/10.1093/nar/gkx038
Publikováno v:
Acta crystallographica. Section F, Structural biology and crystallization communications. 67(Pt 10)
The final step in RNA degradation is the hydrolysis of RNA fragments five nucleotides or less in length (nanoRNA) to mononucleotides. In Escherichia coli this step is carried out by oligoribonuclease (Orn), a DEDD-family exoribonuclease that is conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c55a6ed36431708dd8a9480aa8d330e
https://pubmed.ncbi.nlm.nih.gov/22102036
https://pubmed.ncbi.nlm.nih.gov/22102036
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 70:C212-C212
NanoRNA are RNA molecules 5 nt or less that are generated during several fundamental biological processes, including abortive transcription and RNA turnover. NanoRNA may play a role in the priming of transcription initiation. Degradation of nanoRNA i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e8c63bb0995f1dd247ebb7bc2df87f6
https://doi.org/10.1107/s2053273314097873
https://doi.org/10.1107/s2053273314097873