Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Brad J. Geddes"'
Autor:
Ioannis Roxanis, Laura Ramos Garcia, James M. Murphy, Sidonie Wicky John, Isabelle S Lucet, Andrew J. Kueh, Allison M. Beal, K. Aurelia Ball, Jyoti S. Choudhary, Cheree Fitzgibbon, Richard Newman, Jason W. Upton, Martin Sims, Lu Yu, George Ward, Gianmaria Liccardi, Winnie Fernando, Patrycja Gazinska, Naomi Guppy, Brad J. Geddes, Hyojin Kim, Samuel N. Young, Rachel O. Haich, Pascal Meier, Lung-Yu Liang, Mercedes Pardo, Tomoko Smyth, John Bertin, Tencho Tenev, Alessandro Annibaldi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Necroptosis is a lytic, inflammatory form of cell death that not only contributes to pathogen clearance but can also lead to disease pathogenesis. Necroptosis is triggered by RIPK3-mediated phosphorylation of MLKL, which is thought to initiate MLKL o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60c765171f5733bd4f97d2274902cdc
https://doaj.org/article/028b10c801d94af293be6d1707508113
https://doaj.org/article/028b10c801d94af293be6d1707508113
An intestinal organoid–based platform that recreates susceptibility to T-cell–mediated tissue injury
Autor:
Eugene Rudensky, Jennifer Tsai, Sandra J. Hoffman, Victor J. Torres, David Hudesman, Chen Liu, John Bertin, Ken Cadwell, Thomas Heaney, Brad J. Geddes, Marcel R.M. van den Brink, Jordan E. Axelrad, Yu Matsuzawa-Ishimoto, Xiaomin Yao, Allison M. Beal, Frank Yeung, P'ng Loke, Yusuke Shono, Ashley M. Hine, Jessica A Neil, Samantha L. Schuster, Michael Cammer, Ying-Han Chen, Amina Lazrak, Erin E Zwack, M. Zahidunnabi Dewan, Katherine B Nichols
Publikováno v:
Blood. 135:2388-2401
A goal in precision medicine is to use patient-derived material to predict disease course and intervention outcomes. Here, we use mechanistic observations in a preclinical animal model to design an ex vivo platform that recreates genetic susceptibili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::166102d0480ab9564cf6dd57562155e4
https://doi.org/10.1182/blood.2019004116
https://doi.org/10.1182/blood.2019004116
Autor:
Stéphane Sautet, Emilie Jigorel, Nicolas Faucher, Jamel Meslamani, Lara Kathryn Leister, Pascal Grondin, Julie A. Cox, Bryan W. King, Pamela Nassau, Gemma Victoria White, Brad J. Geddes, Alain Claude-Marie Daugan, Helen H. Sun, Michael T. Ouellette, Pauline Lamoureux, Elizabeth J. Rivera, Scott B. Berger, James H. Thorpe, Philip A. Harris, J. Mosley, Susan E. Hutchinson, Frédéric Donche, John Bertin, Sandra J. Hoffman, Natalie Wellaway, Patrick M. Eidam, Paris Ward, Florent Potvain, Clark A. Sehon, Sebastien Andre Campos, Robert W. Marquis, Peter J. Gough, Mukesh K. Mahajan, Veronique Beneton, Jae U. Jeong, Michelle C. Schaeffer, John D. Lich, Allison M. Beal, Rakesh Nagilla, James Michael Woolven, Bonnie L. Hoffman, Anderson Niall Andrew, Marie-Hélène Fouchet, Deepak Bandyopadhyay, Carol A. Capriotti, Rachel D. Totoritis, Joshua N. Finger, Kishore K. Pasikanti, David D. Wisnoski, Sze-Ling Ng, Nino Campobasso, Nicolas George, Michael Reilly
Publikováno v:
Journal of Medicinal Chemistry. 62:5096-5110
RIP1 kinase regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including inflammatory and neurological diseases. Currently, RIP1 kinase inhibitors have advanced into early clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ff65b82b2e1feff6acc28b9dcac4dc
https://doi.org/10.1021/acs.jmedchem.9b00318
https://doi.org/10.1021/acs.jmedchem.9b00318
Autor:
Qing Wan, Hong Chen, John Bertin, Zekun Peng, Yonghu Huang, Brad J. Geddes, Yuze Zhang, Jean-Luc Tran, Michael Reilly, Guoli Yang, Miao Wang, Haojie Rao, Huihui Li
Publikováno v:
Frontiers in Cardiovascular Medicine
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Objective: Atherosclerosis is an arterial occlusive disease with hypercholesterolemia and hypertension as common risk factors. Advanced-stage stenotic plaque, which features inflammation and necrotic core formation, is the major reason for clinical i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1006e77a1d3e3bf0442714512ffb5516
https://pubmed.ncbi.nlm.nih.gov/34760938
https://pubmed.ncbi.nlm.nih.gov/34760938
Autor:
Carlos Spichiger, Steven Bergink, R. Luke Wiseman, Paulina Troncoso-Escudero, Neeraj Sharma, S. Pablo Sardi, Rene L. Vidal, Cristian Saquel, Pedro Chana-Cuevas, Lars Plate, Kizito Tshitoko Tshilenge, Paula Garcia-Huerta, Daniel R. Henríquez, Swati Naphade, Arun Thiruvalluvan, Hans Richter, Lisa M. Ellerby, Brad J. Geddes, Claudio Hetz, Marisol Cisternas-Olmedo, Gerardo Z. Lederkremer, Marina Shenkman, Felipe A. Court, Peter Thielen, Kenneth A. Longo, Christian Gonzalez-Billault, Di Wu
Publikováno v:
Acta Neuropathologica, 140(5), 737-764. SPRINGER
Acta Neuropathol
Acta Neuropathol
Impaired neuronal proteostasis is a salient feature of many neurodegenerative diseases, highlighting alterations in the function of the endoplasmic reticulum (ER). We previously reported that targeting the transcription factor XBP1, a key mediator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25da26bb87d79b3b9b7508264344ca44
https://research.rug.nl/en/publications/15f5fa78-12a6-49c9-8d0c-be943c0ed201
https://research.rug.nl/en/publications/15f5fa78-12a6-49c9-8d0c-be943c0ed201
Autor:
Peter S. DiStefano, Soratree Charoenthongtrakul, Yong Qi, Brad J. Geddes, Kenneth A. Longo, Derek J. Giuliana, Thomas McDonagh, Elizabeth K. Govek
Publikováno v:
Regulatory Peptides. 150:55-61
Stimulation of the ghrelin receptor (GhrR) by ghrelin results in a variety of metabolic changes including increased food intake, fat storage and insulin resistance. Loss of ghrelin signaling is protective against diet-induced obesity, suggesting that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33270b2444e7c6cdd891282615a3df1
https://doi.org/10.1016/j.regpep.2008.03.011
https://doi.org/10.1016/j.regpep.2008.03.011
Autor:
Christine A. Collins, Victoria Knourek-Segel, Philip R. Kym, Dariusz Wodka, Hing L. Sham, Brad J. Geddes, Rajesh R. Iyengar, Anil Vasudevan, Ju Gao, Su Jen Lai, Elizabeth K. Govek, Thomas A. Fey, Freeman Jennifer C, Gang Zhao, Dennis G Fry, Michael E. Brune, Jennifer Lee Che, Brian D. Dayton, Doug H. Falls, Kennan C. Marsh, Andrew J. Souers, James Brown, Jon Roses, Michael A. Patane, Matthew J. LaMarche, Cathleen Mcdowell, Lee C. Preusser, Lisa E. Hernandez, Mathew M. Mulhern, Courtney Cullis, Tom Marsilje, Sevan Brodjian, Lynch John K, Eugene N. Bush, Sells Todd B, Robin Shapiro, Christopher Blackburn, Andrew S. Judd, Glenn A. Reinhart
Publikováno v:
Journal of Medicinal Chemistry. 48:5888-5891
4-(1-Benzo[1,3]dioxol-5-ylmethylpiperidine-4-ylmethyl)-6-chlorochromen-2-one (7) is a potent, orally bioavailable melanin concentrating hormone receptor 1 (MCHr1) antagonist that causes dose-dependent weight loss in diet-induced obese mice. Further e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b385adec4f57fc115bc33dad4a4acdf7
https://doi.org/10.1021/jm050598r
https://doi.org/10.1021/jm050598r
Publikováno v:
Journal of Neuroendocrinology. 7:411-417
The novel finding that relaxin has an action on the brain was first published in 1984. Since then, it has been shown that exogenous relaxin affects the release of a number of hypothalamo-pituitary hormones and has a robust pressor action. In this pap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c645f89578d47042b50843683bde0ca2
https://doi.org/10.1111/j.1365-2826.1995.tb00777.x
https://doi.org/10.1111/j.1365-2826.1995.tb00777.x
Autor:
Brad J. Geddes, Kristen Morgan, Kenneth A. Longo, Chaoseng Zou, Samantha Gagne, Derek J. Giuliana, Elizabeth K. Govek, Thomas McDonagh, Yong Qi, Peter S. DiStefano, Anna Nolan, Jeffrey O. Saunders, Jeffrey Hixon
Publikováno v:
BMC Physiology
BMC Physiology, Vol 11, Iss 1, p 1 (2011)
BMC Physiology, Vol 11, Iss 1, p 1 (2011)
Background We and others have demonstrated previously that ghrelin receptor (GhrR) knock out (KO) mice fed a high fat diet (HFD) have increased insulin sensitivity and metabolic flexibility relative to WT littermates. A striking feature of the HFD-fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74da8fccc666707a9973124c06d8da1f
https://pubmed.ncbi.nlm.nih.gov/21211044
https://pubmed.ncbi.nlm.nih.gov/21211044
Autor:
Brad J. Geddes, Bruce Kelder, Peter S. DiStefano, Kenneth A. Longo, Darlene E. Berryman, Soratree Charoenthongtrakul, John J. Kopchick
Publikováno v:
Growth hormoneIGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 20(1)
The goal of this study was to examine factors that contribute to energy balance in female GHR −/− mice. We measured energy intake, energy expenditure (EE), fuel utilization, body mass ( M b ) changes and physical activity in 17 month-old female G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6fc432702fefb377ccac9fb8cd017c
https://pubmed.ncbi.nlm.nih.gov/19747867
https://pubmed.ncbi.nlm.nih.gov/19747867