Zobrazeno 1 - 10
of 423
pro vyhledávání: '"Brad H, Rovin"'
Autor:
Insa M. Schmidt, Aditya L. Surapaneni, Runqi Zhao, Dhairya Upadhyay, Wan-Jin Yeo, Pascal Schlosser, Courtney Huynh, Anand Srivastava, Ragnar Palsson, Taesoo Kim, Isaac E. Stillman, Daria Barwinska, Jonathan Barasch, Michael T. Eadon, Tarek M. El-Achkar, Joel Henderson, Dennis G. Moledina, Sylvia E. Rosas, Sophie E. Claudel, Ashish Verma, Yumeng Wen, Maja Lindenmayer, Tobias B. Huber, Samir V. Parikh, John P. Shapiro, Brad H. Rovin, Ian B. Stanaway, Neha A. Sathe, Pavan K. Bhatraju, Josef Coresh, the Kidney Precision Medicine Project, Eugene P. Rhee, Morgan E. Grams, Sushrut S. Waikar
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The kidney tubules constitute two-thirds of the cells of the kidney and account for the majority of the organ’s metabolic energy expenditure. Acute tubular injury (ATI) is observed across various types of kidney diseases and may significan
Externí odkaz:
https://doaj.org/article/41855c04b12d4c92a5497040b3021033
Autor:
Debora L. Gisch, Michelle Brennan, Blue B. Lake, Jeannine Basta, Mark S. Keller, Ricardo Melo Ferreira, Shreeram Akilesh, Reetika Ghag, Charles Lu, Ying-Hua Cheng, Kimberly S. Collins, Samir V. Parikh, Brad H. Rovin, Lynn Robbins, Lisa Stout, Kimberly Y. Conklin, Dinh Diep, Bo Zhang, Amanda Knoten, Daria Barwinska, Mahla Asghari, Angela R. Sabo, Michael J. Ferkowicz, Timothy A. Sutton, Katherine J. Kelly, Ian H. De Boer, Sylvia E. Rosas, Krzysztof Kiryluk, Jeffrey B. Hodgin, Fadhl Alakwaa, Seth Winfree, Nichole Jefferson, Aydın Türkmen, Joseph P. Gaut, Nils Gehlenborg, Carrie L. Phillips, Tarek M. El-Achkar, Pierre C. Dagher, Takashi Hato, Kun Zhang, Jonathan Himmelfarb, Matthias Kretzler, Shamim Mollah, the Kidney Precision Medicine Project (KPMP), Sanjay Jain, Michael Rauchman, Michael T. Eadon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract There is a need to define regions of gene activation or repression that control human kidney cells in states of health, injury, and repair to understand the molecular pathogenesis of kidney disease and design therapeutic strategies. Comprehe
Externí odkaz:
https://doaj.org/article/8d81e0f3c4d54dd6b9a6681fc0df894c
Autor:
Frederick W.K. Tam, James Tumlin, Jonathan Barratt, Brad H. Rovin, Ian S.D. Roberts, Candice Roufosse, H. Terence Cook, Gurjeet Bhangal, Alison L. Brown, Martin Busch, Fayaz Dudhiya, Anne-Marie Duliege, Donald J. Fraser, Daniel P. Gale, Chiu-Ching Huang, Ping-Chin Lai, Meng Lee, Esteban S. Masuda, Stephen P. McAdoo, Alexander R. Rosenkranz, Claudia Sommerer, Gere Sunder-Plassmann, Cheuk-Chun Szeto, Sydney C.W. Tang, Don E. Williamson, Lisa Willcocks, Volker Vielhauer, Min Jeong Kim, Leslie Todd, Hany Zayed, Sandra Tong-Starksen, Richard Lafayette
Publikováno v:
Kidney International Reports, Vol 8, Iss 12, Pp 2546-2556 (2023)
Introduction: We reported increased spleen tyrosine kinase (SYK) expression in kidney biopsies of patients with IgA nephropathy (IgAN) and that inhibition of SYK reduces inflammatory cytokines production from IgA stimulated mesangial cells. Methods:
Externí odkaz:
https://doaj.org/article/66982ca5bf66483cb14ee295eaf07526
Autor:
Brad H Rovin, Samir V Parikh, Catherine Barbey, Taylor L Reynolds, Su Jing Chan, Luke Jandreski, Kyle Ferber
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss Suppl 2 (2024)
Externí odkaz:
https://doaj.org/article/3010dfc9eea5452d82b1ef289ccd0de8
Autor:
Farah Tamirou, Frederic Houssiau, Ali Duarte-García, Maria Dall’Era, Brad H Rovin, Larry J Prokop, Gabriel Figueroa-Parra, Cynthia S Crowson, Michael S Putman, Fernando C Fervenza, Alain Sanchez-Rodriguez, María C Cuéllar-Gutiérrez, Mariana González-Treviño, Jaime Flores-Gouyonnet, José A Meade-Aguilar, M Hassan Murad
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss Suppl 1 (2024)
Externí odkaz:
https://doaj.org/article/a3eee3392158483083aac4b060fe6fad
Autor:
Dana V. Rizk, Brad H. Rovin, Hong Zhang, Naoki Kashihara, Bart Maes, Hernán Trimarchi, Vlado Perkovic, Matthias Meier, Dmitrij Kollins, Olympia Papachristofi, Alan Charney, Jonathan Barratt
Publikováno v:
Kidney International Reports, Vol 8, Iss 5, Pp 968-979 (2023)
Introduction: Targeting the alternative complement pathway (AP) is an attractive therapeutic strategy because of its role in immunoglobulin A nephropathy (IgAN) pathophysiology. Iptacopan (LNP023), a proximal complement inhibitor that specifically bi
Externí odkaz:
https://doaj.org/article/e273eb3d888049e0b8276461498c3f08
Publikováno v:
Lupus Science and Medicine, Vol 9, Iss Suppl 3 (2022)
Externí odkaz:
https://doaj.org/article/d78a72850a3544ee99265955f6e644fa
Autor:
Brad H Rovin, Haikady N Nagaraja, Ana Malvar, Valeria G Alberton, Bruno J Lococo, Maria C Lourenco, Joaquín Martinez, Mauro Elencwajg
Publikováno v:
Lupus Science and Medicine, Vol 9, Iss Suppl 3 (2022)
Externí odkaz:
https://doaj.org/article/ab18ae107167403fac812fa07f5bbd58
Autor:
Brad H Rovin, Hans-Joachim Anders, Ming-hui Zhao, Ana Malvar, David A Roth, Keiju Hiromura, Jennifer Gilbride, Yulia Green, Anuradha Madan, Angela Jones- Leone, Tania Gonzalez-Rivera
Publikováno v:
Lupus Science and Medicine, Vol 9, Iss Suppl 3 (2022)
Externí odkaz:
https://doaj.org/article/7f29eaec17ea4f6aa6d1588fc6500122
Autor:
Isabelle Ayoub, John P. Shapiro, Huijuan Song, Xiaolan Lily Zhang, Samir Parikh, Salem Almaani, Sethu Madhavan, Sergey V. Brodsky, Anjali Satoskar, Cherri Bott, Lianbo Yu, Michael Merchant, John Klein, Juan M. Mejia-Vilet, Tibor Nadasdy, Dan Birmingham, Brad H. Rovin
Publikováno v:
Kidney International Reports, Vol 6, Iss 2, Pp 484-492 (2021)
Introduction: Membranous nephropathy (MN) is a common cause of adult nephrotic syndrome that progresses to end-stage kidney disease in up to 40% of cases. It is an autoimmune disease characterized by glomerular subepithelial deposits containing IgG.
Externí odkaz:
https://doaj.org/article/c00a7fe67c1a4fd98f948276fdcb3a76