Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Brad G. Magor"'
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
DNA mutagenesis during antibody affinity maturation has potentially oncogenic or autoimmune outcomes if not tightly controlled as it is in mammalian germinal centers. Cold blooded vertebrates lack germinal centers, yet have a functional Ig gene mutat
Externí odkaz:
https://doaj.org/article/5ad4967b9135449bae5eb4b92f6d3464
Autor:
Brad G. Magor
Publikováno v:
Biology, Vol 4, Iss 3, Pp 512-524 (2015)
It has long been believed that fish lack antibody affinity maturation, in part because they were thought to lack germinal centers. Recent research done on sharks and bony fishes indicates that these early vertebrates are able to affinity mature their
Externí odkaz:
https://doaj.org/article/b624c79c76324c8dbb177eaa9592fa34
Publikováno v:
Developmental & Comparative Immunology. 119:104021
There has been a longstanding question of whether affinity maturation occurs in ectotherms, and if it does, where in tissues this happens. Although cold-blooded vertebrates (ectotherms) lack histologically discernible germinal centers, they have a fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177fd719ed4116448523bcc022fc453b
https://doi.org/10.1016/j.dci.2021.104021
https://doi.org/10.1016/j.dci.2021.104021
Autor:
Daniela Villota-Herdoiza, Emmanuel A. Pila, Brad G. Magor, Geoffrey C. Waldbieser, Sylvie M. A. Quiniou
Publikováno v:
Fish & Shellfish Immunology. 35:1981-1987
In order to better understand antibody affinity maturation in fishes we sought to identify gene regulatory elements that could drive expression of activated B-cell specific fluorescent reporter transgenes in zebrafish. Specifically the promoter and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2777c0339675fa3623a1d25d542ab497
https://doi.org/10.1016/j.fsi.2013.09.035
https://doi.org/10.1016/j.fsi.2013.09.035
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 197(4)
In many nonmammalian vertebrates, the genomic organization of the MHC class I region leads to biased expression of a single classical MHC class I gene coevolving with TAP transporters, whereas class I genes are poorly expressed. This contrasts to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef60dc0bba2c711f755c8728e747b95d
https://pubmed.ncbi.nlm.nih.gov/27430716
https://pubmed.ncbi.nlm.nih.gov/27430716
Publikováno v:
Developmental & Comparative Immunology. 35:352-359
Many fish have, in addition to IgM and IgD, a third isotype called IgZ or IgT. The ζ-chain locus is embedded among the Ig heavy chain V-, D- and J-elements in a manner reminiscent of the TcR δ/α locus. Isotype selection thus occurs during VDJ reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe648fcd1e818efca82fb786d36103d
https://doi.org/10.1016/j.dci.2010.10.010
https://doi.org/10.1016/j.dci.2010.10.010
Autor:
James L. Stafford, Katharine E. Magor, Miodrag Belosevic, Brad G. Magor, Kristofor K. Ellestad
Publikováno v:
Developmental & Comparative Immunology. 27:685-698
An expressed sequence tag screen of a macrophage activation factor and lipopolysaccharide (LPS) stimulated goldfish macrophage subtractive library generated several transcripts of a putative teleost homologue of the toll-like receptor (TLR) family. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773bc0045fa0e646b0c9d7087eb2db03
https://doi.org/10.1016/s0145-305x(03)00041-7
https://doi.org/10.1016/s0145-305x(03)00041-7
Autor:
Laura Diaz-Satizabal, Brad G. Magor
Publikováno v:
Developmental and comparative immunology. 48(1)
Pigmented or “melano-” macrophages are prominent in lymphoid and non-lymphoid tissues of poikilotherms. Though they have been extensively studied in situ only recently has a means to isolate them from other cell types been established. We provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768b984a00b03abf4c10f7c2d6ea27f8
https://pubmed.ncbi.nlm.nih.gov/25453581
https://pubmed.ncbi.nlm.nih.gov/25453581
Autor:
Noemi Delgado, Yvonne Pao, Caitlyn McGue, Brad G. Magor, Dawne M. Page, Bradley H. Jacobsen, Neil C. Chi, David N. Pratt, Kanako L. Lewis, Sarah E. Schale, Hongbo Yang, Julien Y. Bertrand, David Traver, Valérie Wittamer, Alyssa Doty
Publikováno v:
Blood, Vol. 122, No 8 (2013) pp. e1-11
Teleost fish are among the most ancient vertebrates possessing an adaptive immune system with B and T lymphocytes that produce memory responses to pathogens. Most bony fish, however, have only 2 types of B lymphocytes, in contrast to the 4 types avai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46301b24e2c597f6bcdc3d66c813c317
https://archive-ouverte.unige.ch/unige:40864
https://archive-ouverte.unige.ch/unige:40864
Autor:
Brad G. Magor, Vasco M. Barreto
Publikováno v:
Developmental and comparative immunology. 35(9)
In the ten years since the discovery of activation-induced cytidine deaminase (AID) there has been considerable effort to understand the mechanisms behind this enzyme's ability to target and modify immunoglobulin genes leading to somatic hypermutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a433424689c82f5871e3354f2d819c3
https://pubmed.ncbi.nlm.nih.gov/21349283
https://pubmed.ncbi.nlm.nih.gov/21349283