Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Brad Fell"'
Autor:
John Fischer, Karyn Bouhana, Mark J. Chicarelli, Josh Dahlke, Brad Fell, Jennifer Fulton, Anna Guarnieri, Ravi Jalluri, Amber Johnson, Brent Mclean, Max Mejia, Rob Rieger, John Robinson, Mareli Rodriguez, Francis Sullivan, Yang Wang, Shannon Winski, Yeyun Zhou
Publikováno v:
Cancer Research. 82:167-167
The fibroblast growth factor receptor (FGFR) family of protein tyrosine kinases plays a role in many physiological processes including angiogenesis and wound healing. FGFR mutations, fusions, rearrangements, and amplifications have been linked to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d82e7b062a7d969a9dd69a8753ada94f
https://doi.org/10.1158/1538-7445.am2022-167
https://doi.org/10.1158/1538-7445.am2022-167
Autor:
Dylan P. Hartley, Suzy Brown, Karyn Bouhana, Walter E. DeWolf, Jay Brad Fell, Li Ren, Patrice Lee, David A. Moreno, Ross D. Wallace, Deborah A. Anderson, Lance Williams
Publikováno v:
Cancer Research. 81:1473-1473
Although approved BRAF inhibitors have transformed the treatment of patients with certain BRAF V600 mutant cancers, their long-term efficacy is thought to be limited by poor brain penetration. As a result, disease progression in the brain is a signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2423481948a3a94597760654202d66a0
https://doi.org/10.1158/1538-7445.am2021-1473
https://doi.org/10.1158/1538-7445.am2021-1473
Publikováno v:
The Journal of Organic Chemistry. 63:1309-1311
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddd02d484342b76214b701e843be26d8
https://doi.org/10.1021/jo970659w
https://doi.org/10.1021/jo970659w
Autor:
James D. Winkler, Susan L. Gloor, Michael J. Humphries, Walt E. DeWolf, Kelly Regal, Kevin Ronald Condroski, Greg Miknis, John Fischer, John A. Josey, Boys Mark Laurence, Mareli Rodriguez, Stefan Gross, Kevin Koch, Georg Topalov, Lisa DeMeese, John S. Zuzack, Rui Xu, Eli M. Wallace, Kristin Shotts, Brad Fell, Nicholas J. Raddatz
Publikováno v:
Cancer Research. 70:4484-4484
As a consequence of a variety of genetic lesions, the PI3K/Akt pathway is constitutively activated in a large proportion of human cancers. The mTOR kinase plays an important role in this pathway as the key component of two independent signaling compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddb9ce1971ed4c9e155cdd275bc89ac7
https://doi.org/10.1158/1538-7445.am10-4484
https://doi.org/10.1158/1538-7445.am10-4484
Autor:
Lisa DeMeese, Susan L. Gloor, Stefan Gross, Kevin Koch, Greg Miknis, Walt E. DeWolf, John A. Josey, Kelly Regal, Rui Xu, Mike Humphries, Gregg Hastings, James D. Winkler, John S. Zuzack, John P. Fischer, Eli M. Wallace, Brad Fell, Michael Burkard
Publikováno v:
Molecular Cancer Therapeutics. 8:B267-B267
Through alterations in the PTEN and PI3K genes, the PI3K / Akt pathway is constitutively activated in human cancers. mTOR kinase plays an unique role in this pathway as the key component of two independent signaling complexes (mTORC1 (raptor - rapamy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08e77e6a4d0815b92ea2589aa572fcde
https://doi.org/10.1158/1535-7163.targ-09-b267
https://doi.org/10.1158/1535-7163.targ-09-b267