Výsledky vyhledávání - "Brad E Sleebs"

Akademický článek

Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics.

Publikováno v: PLoS Biology, Vol 21, Iss 4, p e3002066 (2023)

With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red blood cell (RBC) invasion, and

Externí odkaz: https://doaj.org/article/d4ae40a3c3394669ac6efd4a149b5ec0

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Akademický článek

A revised mechanism for how Plasmodium falciparum recruits and exports proteins into its erythrocytic host cell.

Autor: Mikha Gabriela, Kathryn M Matthews, Cas Boshoven, Betty Kouskousis, Thorey K Jonsdottir, Hayley E Bullen, Joyanta Modak, David L Steer, Brad E Sleebs, Brendan S Crabb, Tania F de Koning-Ward, Paul R Gilson

Publikováno v: PLoS Pathogens, Vol 18, Iss 2, p e1009977 (2022)

Plasmodium falciparum exports ~10% of its proteome into its host erythrocyte to modify the host cell's physiology. The Plasmodium export element (PEXEL) motif contained within the N-terminus of most exported proteins directs the trafficking of those

Externí odkaz: https://doaj.org/article/255e629500da4e7bab4f1622c9b59485

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Akademický článek

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

Autor: Michael J Coffey, Brad E Sleebs, Alessandro D Uboldi, Alexandra Garnham, Magdalena Franco, Nicole D Marino, Michael W Panas, David JP Ferguson, Marta Enciso, Matthew T O'Neill, Sash Lopaticki, Rebecca J Stewart, Grant Dewson, Gordon K Smyth, Brian J Smith, Seth L Masters, John C Boothroyd, Justin A Boddey, Christopher J Tonkin

Publikováno v: eLife, Vol 4 (2015)

Infection by Toxoplasma gondii leads to massive changes to the host cell. Here, we identify a novel host cell effector export pathway that requires the Golgi-resident aspartyl protease 5 (ASP5). We demonstrate that ASP5 cleaves a highly constrained a

Externí odkaz: https://doaj.org/article/87c2bb0c16e043169ac8333f604bb8e0

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Akademický článek

HIV-1 and Human PEG10 Frameshift Elements Are Functionally Distinct and Distinguished by Novel Small Molecule Modulators.

Autor: Tony S Cardno, Yosuke Shimaki, Brad E Sleebs, Kurt Lackovic, John P Parisot, Rebecca M Moss, Caillan Crowe-McAuliffe, Suneeth F Mathew, Christina D Edgar, Torsten Kleffmann, Warren P Tate

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0139036 (2015)

Frameshifting during translation of viral or in rare cases cellular mRNA results in the synthesis of proteins from two overlapping reading frames within the same mRNA. In HIV-1 the protease, reverse transcriptase, and integrase enzymes are in a secon

Externí odkaz: https://doaj.org/article/20a5de53f7ec45b591411810ac7d69b1

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Akademický článek

Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites.

Autor: Brad E Sleebs, Sash Lopaticki, Danushka S Marapana, Matthew T O'Neill, Pravin Rajasekaran, Michelle Gazdik, Svenja Günther, Lachlan W Whitehead, Kym N Lowes, Lea Barfod, Lars Hviid, Philip J Shaw, Anthony N Hodder, Brian J Smith, Alan F Cowman, Justin A Boddey

Publikováno v: PLoS Biology, Vol 12, Iss 7, p e1001897 (2014)

The malaria parasite Plasmodium falciparum exports several hundred proteins into the infected erythrocyte that are involved in cellular remodeling and severe virulence. The export mechanism involves the Plasmodium export element (PEXEL), which is a c

Externí odkaz: https://doaj.org/article/577c998d81b343c095e557df66f4d3e1

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The Invention of WM382, a Highly Potent PMIX/X Dual Inhibitor toward the Treatment of Malaria

Publikováno v: ACS Medicinal Chemistry Letters. 13:1745-1754

Drug resistance to first-line antimalarials-including artemisinin-is increasing, resulting in a critical need for the discovery of new agents with novel mechanisms of action. In collaboration with the Walter and Eliza Hall Institute and with funding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5c87b18003c3926bf80d926fcdff26
https://doi.org/10.1021/acsmedchemlett.2c00355

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The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites

Autor: Oliver Looker, Madeline G. Dans, Hayley E. Bullen, Brad E. Sleebs, Brendan S. Crabb, Paul R. Gilson

Publikováno v: Traffic. 23:442-461

Plasmodium falciparum parasites which cause malaria, traffic hundreds of proteins into the red blood cells (RBCs) they infect. These exported proteins remodel their RBCs enabling host immune evasion through processes such as cytoadherence that greatl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f981b5ac5b72d73b0195d0fe45a4081e
https://doi.org/10.1111/tra.12862

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