Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Brad Dykstra"'
Autor:
Russell Griffin, Junning Huang, Robert Sackstein, Brad Dykstra, Clare Baecher-Allan, Belinda J. Kaskow, Conor Donnelly, Nandini Mondal
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports
Scientific Reports
While human Tregs hold immense promise for immunotherapy, their biologic variability poses challenges for clinical use. Here, we examined clinically-relevant activities of defined subsets of freshly-isolated and culture-expanded human PBMC-derived Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b731aaca80d49bcb487f2630d7d0c097
http://link.springer.com/article/10.1038/s41598-017-17981-z
http://link.springer.com/article/10.1038/s41598-017-17981-z
Autor:
Sunita Patel-Hett, Douglas Lazarus, Christian G. Peters, Amanda Leung, Sayaka Masuko, Dora E Kohnke, Lindsay Tomczak, Angelique Meredith, Brad Dykstra, Marcus Lehmann, Silvia Giannini, Dean Falb, Ryan Carpenter, Po-Shun Lee, Sophia Pete, Ashley J Russo
Publikováno v:
Blood. 138:1001-1001
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet counts ( Current treatment strategies for ITP include non-specific immunosuppression (steroids, rituximab), inhibition of platelet clearance (immunoglobulins, splen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b7f4593ede3ca470c693bd8ec511104
https://doi.org/10.1182/blood-2021-150823
https://doi.org/10.1182/blood-2021-150823
Autor:
Derrick J. Rossi, Joel A. Spencer, Jungmin Lee, Leonard D. Shultz, Michael A. Brehm, Robert Sackstein, Brad Dykstra, Charles P. Lin, Dale L. Greiner, Laurie L. Kenney
Publikováno v:
Journal of Clinical Investigation. 127:2433-2437
Generation of functional hematopoietic stem and progenitor cells (HSPCs) from human pluripotent stem cells (PSCs) has been a long-sought-after goal for use in hematopoietic cell production, disease modeling, and eventually transplantation medicine. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b73f00fd2a23ce8fdfeb0a905b9d9d59
https://doi.org/10.1172/jci92030
https://doi.org/10.1172/jci92030
Publikováno v:
Platelets. 28:472-477
Platelets, responsible for clot formation and blood vessel repair, are produced by megakaryocytes in the bone marrow. Platelets are critical for hemostasis and wound healing, and are often provided following surgery, chemotherapy, and major trauma. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec97d1a37e7a4708f87ce36d4033519
https://doi.org/10.1080/09537104.2016.1265922
https://doi.org/10.1080/09537104.2016.1265922
Autor:
Derrick J. Rossi, Zhengliang L. Wu, Brad Dykstra, Haixiao Yu, Charles P. Lin, Robert Sackstein, Luke J. Mortensen, Jungmin Lee
Publikováno v:
Stem cells (Dayton, Ohio). 34(10)
Human mesenchymal stem cells (MSCs) hold great promise in cellular therapeutics for skeletal diseases but lack expression of E-selectin ligands that direct homing of blood-borne cells to bone marrow. Previously, we described a method to engineer E-se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f8980e3849942abdc8f8d554482e6b
https://pubmed.ncbi.nlm.nih.gov/27335219
https://pubmed.ncbi.nlm.nih.gov/27335219
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, 208(13), 2691-2703. ROCKEFELLER UNIV PRESS
Journal of Experimental Medicine, 208(13), 2691-2703. ROCKEFELLER UNIV PRESS
As shown using clonal assays, the mouse HSC population undergoes quantitative as well as qualitative changes with age, including lineage differentiation, HSC pool size, marrow-homing efficiency, and self-renewal.
Hematopoietic stem cell (HSC) po
Hematopoietic stem cell (HSC) po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51eb829aff3d3044db1f056ba9f2419b
https://doi.org/10.1084/jem.20111490
https://doi.org/10.1084/jem.20111490
Autor:
Maura Gasparetto, Yun Zhao, David G. Kent, John Cheyne, Connie J. Eaves, Brad Dykstra, Michael R. Copley, Claudia Benz, Elaine Ma, Michelle B. Bowie, Allen Delaney, Yongjun Zhao, Marco A. Marra, Stefan Wöhrer, Clayton A. Smith
Publikováno v:
Blood. 113:6342-6350
Hematopoietic stem cells (HSCs) are generally defined by their dual properties of pluripotency and extensive self-renewal capacity. However, a lack of experimental clarity as to what constitutes extensive self-renewal capacity coupled with an absence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0442b7a8a875b19aeb60a15cadecb9e4
https://doi.org/10.1182/blood-2008-12-192054
https://doi.org/10.1182/blood-2008-12-192054
Publikováno v:
Immunogenetics
Stem cells are unique in that they possess both the capacity to self-renew and thereby maintain their original pool as well as the capacity to differentiate into mature cells. In the past number of years, transcriptional profiling of enriched stem ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ce3c4719c3b7ebdb425c0696603608
https://doi.org/10.1007/s00251-008-0305-3
https://doi.org/10.1007/s00251-008-0305-3
Autor:
Brad Dykstra, Gerald de Haan
Publikováno v:
Cell and Tissue Research. 331(1):91-101
A functional decline of the immune system occurs during organismal aging that is attributable, in large part, to changes in the hematopoietic stem cell (HSC) compartment. In the mouse, several hallmark age-dependent changes in the HSC compartment hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c76dc458fc5be193edbf92340ef61bc
https://doi.org/10.1007/s00441-007-0529-9
https://doi.org/10.1007/s00441-007-0529-9
Autor:
David G. Kent, Shang-Jung Lee, Michelle B. Bowie, Lindsay McCaffrey, Ryan R. Brinkman, Brad Dykstra, Melisa J. Hamilton, Kristin Lyons, Connie J. Eaves
Publikováno v:
Cell stem cell, 1(2), 218-229. CELL PRESS
SummaryHeterogeneity in the differentiation behavior of hematopoietic stem cells is well documented but poorly understood. To investigate this question at a clonal level, we isolated a subpopulation of adult mouse bone marrow that is highly enriched
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6b53415fea61ef82fb87fd5fcf833d
https://doi.org/10.1016/j.stem.2007.05.015
https://doi.org/10.1016/j.stem.2007.05.015