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pro vyhledávání: '"Brad D. Wallentine"'
Autor:
Ying Wang, Vira Tretyachenko-Ladokhina, Hartmut Luecke, Martha Tan, Brad D. Wallentine, Donald F. Senear
Publikováno v:
Acta crystallographica. Section D, Biological crystallography, vol 69, iss Pt 10
To gain insights into the mechanisms by which certain second-site suppressor mutations rescue the function of a significant number of cancer mutations of the tumor suppressor protein p53, X-ray crystallographic structures of four p53 core-domain vari
Autor:
Peter K. Kaiser, Rommie E. Amaro, A. Richard Chamberlin, Brad D. Wallentine, Faezeh Salehi, Dawei Lin, Hartmut Luecke, Chiung-Kuang Chen, Roberta Baronio, Christopher D. Wassman, Linda V. Hall, Özlem Demir, Richard H. Lathrop, Benjamin P. Chung, G. Wesley Hatfield
Publikováno v:
Nature Communications
The tumour suppressor p53 is the most frequently mutated gene in human cancer. Reactivation of mutant p53 by small molecules is an exciting potential cancer therapy. Although several compounds restore wild-type function to mutant p53, their binding s