Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Brad A. Perkins"'
Autor:
Suzanne Brewerton, Lining Guo, Amalio Telenti, Nicholas J. Schork, Tao Long, Yaron Turpaz, J. Craig Venter, Jonas Zierer, Hung-Chun Yu, Cristina Menni, Chad Garner, Michael A. Hicks, Helen Messier, Anne M. Evans, C. Thomas Caskey, Massimo Mangino, William H. Biggs, Kerrin S. Small, Brad A. Perkins, Tim D. Spector, Luke A. D. Miller, Ewen F. Kirkness
Publikováno v:
Nature Genetics. 49:568-578
Genetic factors modifying the blood metabolome have been investigated through genome-wide association studies (GWAS) of common genetic variants and through exome sequencing. We conducted a whole-genome sequencing study of common, low-frequency and ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04645a0a5924f697f264223698571667
https://doi.org/10.1038/ng.3809
https://doi.org/10.1038/ng.3809
Autor:
Hung-Chun Yu, Ying-Chen Claire Hou, C. Thomas Caskey, Naisha Shah, Amalio Telenti, Brad A. Perkins, Eric Dec, Rachana Sainger, J. Craig Venter
There is a significant interest in the standardized classification of human genetic variants. The availability of new large datasets generated through genome sequencing initiatives provides a ground for the computational evaluation of the supporting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc2d6743a67de4f17efd452fce3b280
Autor:
Julia di Iulio, Suzanne Brewerton, Ewen F. Kirkness, Nadeem Bulsara, Yaron Turpaz, Emily H. M. Wong, Brad A. Perkins, Martin M. Fabani, Amalio Telenti, Efren Sandoval, Levi C. T. Pierce, Gary Metzker, Naisha Shah, Chao Xie, Ahmed A. Moustafa, William H. Biggs, Chad Garner, J. Craig Venter, Franz Josef Och
We report on the sequencing of 10,545 human genomes at 30-40x coverage with an emphasis on quality metrics and novel variant and sequence discovery. We find that 84% of an individual human genome can be sequenced confidently. This high confidence reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be2879a04bf61a614279d8c5f3ecfc4
https://doi.org/10.1101/061663
https://doi.org/10.1101/061663
Autor:
Nicholas Cohen, Michael Moore, Brad T. Perkins, Robert Erickson, Rajiv Doreswamy, Christopher D. Bolszo, Randall Williams, Karen Richardson
Publikováno v:
AIAA SPACE 2015 Conference and Exposition.
The National Institute of Rocket Propulsion Systems (NIRPS) was established in 2011 with the primary goal to maintain and advance United States leadership in all aspects of rocket propulsion. NIRPS recognized that a clear view and understanding of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fa3e5d379706b758173734b397494c2
https://doi.org/10.2514/6.2015-4638
https://doi.org/10.2514/6.2015-4638
Publikováno v:
Cell Metabolism. 23:949-950
The genetic mechanisms mediating longevity and maximum lifespan of the human species are likely different than those explaining differences in life expectancy and healthspan across individuals. Both of these perspectives are important and can be sepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b003871b307c91da89915959041ad82
https://doi.org/10.1016/j.cmet.2016.06.002
https://doi.org/10.1016/j.cmet.2016.06.002
Autor:
Kimberly Pelak, Janine Cooc, Rachana Sainger, Ally Perlina, Heather L Smith, Ramlah Nehring, Ezra E.W. Cohen, Thanemozhi G. Natarajan, Wayne Delport, Eve Shinbrot, Kenneth Joel Bloom, Brad A. Perkins, Boyko Kakaradov, Alexandra E Gylfe, Daniel Jones, Paul Choppa, Corine K. Lau, Subha Krishnan, William H. Biggs
Publikováno v:
Journal of Clinical Oncology. 35:e23118-e23118
e23118 Background: Current targeted cancer therapies rely on the identification of clinically relevant somatic alterations in the tumor. Hotspot gene-panels and exome sequencing are designed to quickly assess somatic variations in frequently mutated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2df5618c08c5a1d674d813f902c3acdb
https://doi.org/10.1200/jco.2017.35.15_suppl.e23118
https://doi.org/10.1200/jco.2017.35.15_suppl.e23118
Autor:
Rachana Sainger, William H. Biggs, Ramlah Nehring, Alex Thomas, Brad A. Perkins, Ezra E.W. Cohen, Boyko Kakaradov, Alexandra E Gylfe, Kimberly Pelak, Ally Perlina, Thanemozhi G. Natarajan, Heather L Smith, Eve Shinbrot, Wayne Delport, Corine K. Lau, Subha Krishnan, Kenneth Joel Bloom
Publikováno v:
Journal of Clinical Oncology. 35:e23153-e23153
e23153 Background: Recent advancements in NGS technology have enabled precision medicine based on tumor-specific genomic alterations. However, the complex nature of tumor biology demands an integrative analysis of genomic variations to identify conve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa1e0244ca46734eb6fade7ada912ab0
https://doi.org/10.1200/jco.2017.35.15_suppl.e23153
https://doi.org/10.1200/jco.2017.35.15_suppl.e23153
Autor:
Leonard W. Mayer, Nancy E. Rosenstein, Brad A. Perkins, Michael W. Reeves, Brian D. Plikaytis, David S. Beall, Maria Lucia Tondella, Tanja Popovic, Anne M. Whitney, Claudio Tavares Sacchi
Publikováno v:
The Journal of infectious diseases. 182(4)
Two hundred eighty-one sporadic Neisseria meningitidis serogroup B isolates, collected through active laboratory-based surveillance, were selected to be analyzed by PorA variable region (VR) typing to determine the prevalence of PorA types in the Uni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c69605ade7be97fec1bb881046c5ced
https://pubmed.ncbi.nlm.nih.gov/10979914
https://pubmed.ncbi.nlm.nih.gov/10979914
Publikováno v:
The Pediatric infectious disease journal. 18(12)
Background. Although the meningococcal polysaccharide vaccine has contributed to the control of Group A meningitis in the meningitis belt of Africa, recurrent large outbreaks have led to questions regarding vaccination strategy. We evaluated current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cded8d2eb96505dca5d953c6aa10e8fa
https://pubmed.ncbi.nlm.nih.gov/10608623
https://pubmed.ncbi.nlm.nih.gov/10608623
Autor:
Brad T. Perkins, Hector M. Rodriguez
Publikováno v:
40th Structures, Structural Dynamics, and Materials Conference and Exhibit.
A feasibility study on the implementation of passive vibration isolation for the Japanese International Standard Payload Rack/Microgravity Science Glovebox Facility is presented. Predictions on the expected acceleration environment aboard the Interna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15e87fd51953696a81141a0984c656ad
https://doi.org/10.2514/6.1999-1291
https://doi.org/10.2514/6.1999-1291