Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Brad A. McMullen"'
Publikováno v:
Protein Science. 4:740-746
The locations of disulfide bonds and free cysteines in the heavy and light chains of recombinant human factor VIII were determined by sequence analysis of fragments produced by chemical and enzymatic digestions. The A1 and A2 domains of the heavy cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a100d61c106fc0456cd563588286b14
https://doi.org/10.1002/pro.5560040413
https://doi.org/10.1002/pro.5560040413
Publikováno v:
Blood. 98:1662-1666
von Willebrand factor (vWF) is synthesized in megakaryocytes and endothelial cells as a very large multimer, but circulates in plasma as a group of multimers ranging from 500 to 10 000 kd. An important mechanism for depolymerization of the large mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991170b478a18cf589d33a543cf284ff
https://doi.org/10.1182/blood.v98.6.1662
https://doi.org/10.1182/blood.v98.6.1662
Autor:
Brad A. McMullen, Dominic W. Chung, José A. López, Minhua Ling, Junmei Chen, Xiaoyun Fu, John Kulman, Yi Wang
Publikováno v:
Blood. 115(3)
Elevated plasma von Willebrand factor (VWF) and low ADAMTS13 activity have been reported in several inflammatory states, including sepsis and acute respiratory distress syndrome. One hallmark of inflammation is neutrophil activation and production of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928a7c0a2f50c74a3155909500878cad
https://pubmed.ncbi.nlm.nih.gov/20093409
https://pubmed.ncbi.nlm.nih.gov/20093409
Publikováno v:
Thrombosis Research. 63:569-575
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67dfdb70914f35f2cbff391d1e0a40a3
https://doi.org/10.1016/0049-3848(91)90184-x
https://doi.org/10.1016/0049-3848(91)90184-x
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 103(49)
ADAMTS-13, a metalloprotease in plasma, specifically cleaves the Tyr-1605–Met-1606 bond in the A2 domain of von Willebrand factor (VWF) to regulate the polymer distribution of VWF in circulation, which is critical for primary hemostasis. A 73-aa pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e324810c524323cabfb6248b64accc77
https://pubmed.ncbi.nlm.nih.gov/17121983
https://pubmed.ncbi.nlm.nih.gov/17121983
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 4(1)
Summary. Background: A deficiency in the plasma metalloprotease ADAMTS-13 is associated with deposition of microvascular thrombi that cause thrombotic thrombocytopenic purpura. Current assays for ADAMTS-13 are technically complex and time-consuming.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12cbd6c58734e7dcc83f9c927d0c876
https://pubmed.ncbi.nlm.nih.gov/16409462
https://pubmed.ncbi.nlm.nih.gov/16409462
Publikováno v:
Biochemistry. 40(50)
hK4 (prostase, KLK4), a recently cloned prostate-specific serine protease and a member of the tissue kallikrein family, is a zymogen composed of 228 amino acid residues including an amino-terminal propiece, Ser-Cys-Ser-Gln-. A chimeric form of hK4 (c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02359a9a0b1d63394629053a40b822e0
https://pubmed.ncbi.nlm.nih.gov/11735417
https://pubmed.ncbi.nlm.nih.gov/11735417
Publikováno v:
Biochemistry. 30(8)
The location of 16 of the 18 disulfide bonds in human plasma prekallikrein was determined by amino acid sequence analysis of cystinyl peptides produced by chemical and enzymatic digestions. A unique structure, named the apple domain, was established
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63e70aba8068772d9d17a256679ef04
https://pubmed.ncbi.nlm.nih.gov/1998666
https://pubmed.ncbi.nlm.nih.gov/1998666
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781468460148
Ascaris suum and Ascaris hominis are intestinal endoparasitic nematodes. They live in hostile proteolytic environments and infect pigs and humans, respectively. Over one-quarter of the world’s human population (Muller, 1979) and masses of pigs are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47d01f38460bc72732bea704684c1bdf
https://doi.org/10.1007/978-1-4684-6012-4_6
https://doi.org/10.1007/978-1-4684-6012-4_6
Autor:
Brad A. McMullen, Minhua Ling, Xiaoyun Fu, José A. López, Dominic W. Chung, Junmei Chen, John Kulman
Publikováno v:
Blood. 112:3921-3921
During inflammation, activated neutrophils go through the oxidative burst, releasing various oxidants, including superoxide radical, hydrogen peroxide, and hypochlorous acid (HOCl). Activated neutrophils also release myeloperoxidase (MPO), which gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f427f46e34ee29d68136e94f19432d4a
https://doi.org/10.1182/blood.v112.11.3921.3921
https://doi.org/10.1182/blood.v112.11.3921.3921