Výsledky vyhledávání - "Brad A Bryan"

Akademický článek

Targeting of beta adrenergic receptors results in therapeutic efficacy against models of hemangioendothelioma and angiosarcoma.

Autor: Jessica M Stiles, Clarissa Amaya, Steven Rains, Dolores Diaz, Robert Pham, James Battiste, Jaime F Modiano, Victor Kokta, Laura E Boucheron, Dianne C Mitchell, Brad A Bryan

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e60021 (2013)

Therapeutic targeting of the beta-adrenergic receptors has recently shown remarkable efficacy in the treatment of benign vascular tumors such as infantile hemangiomas. As infantile hemangiomas are reported to express high levels of beta adrenergic re

Externí odkaz: https://doaj.org/article/4b2b549a97aa468090e7e8cace6fc211

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Akademický článek

Propranolol Sensitizes Vascular Sarcoma Cells to Doxorubicin by Altering Lysosomal Drug Sequestration and Drug Efflux

Autor: Jhuma Saha, Jong Hyuk Kim, Clarissa N. Amaya, Caleb Witcher, Ali Khammanivong, Derek M. Korpela, David R. Brown, Josephine Taylor, Brad A. Bryan, Erin B. Dickerson

Publikováno v: Frontiers in Oncology, Vol 10 (2021)

Angiosarcoma is a rare cancer of blood vessel–forming cells with a high patient mortality and few treatment options. Although chemotherapy often produces initial clinical responses, outcomes remain poor, largely due to the development of drug resis

Externí odkaz: https://doaj.org/article/0b6f2c0f201a406490f6a53dd873bc1e

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Akademický článek

Beta Adrenergic Signaling: A Targetable Regulator of Angiosarcoma and Hemangiosarcoma

Autor: Erin B. Dickerson, Brad A. Bryan

Publikováno v: Veterinary Sciences, Vol 2, Iss 3, Pp 270-292 (2015)

Human angiosarcomas and canine hemangiosarcomas are highly aggressive cancers thought to arise from cells of vascular origin. The pathological features, morphological organization, and clinical behavior of canine hemangiosarcomas are virtually indist

Externí odkaz: https://doaj.org/article/7246630f942b44e8938767896ab586e1

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Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning

Publikováno v: Laboratory investigation; a journal of technical methods and pathology. 101(12)

Osteosarcoma has a guarded prognosis. A major hurdle in developing more effective osteosarcoma therapies is the lack of disease-specific biomarkers to predict risk, prognosis, or therapeutic response. Exosomes are secreted extracellular microvesicles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245dd260ed1d2f34e885c10652dc3fc6
https://pubmed.ncbi.nlm.nih.gov/34489559

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Regression of primary cardiac angiosarcoma and metastatic nodules following propranolol as a single agent treatment

Autor: Anoop P. Ayyappan, Dana Galvan, Brad A. Bryan

Publikováno v: Oncoscience

Angiosarcoma is the most common malignant cardiac tumor. Cardiac angiosarcoma is a highly lethal neoplasm that is largely resistant to conventional anti-cancer therapy. Mean survival of patients with cardiac angiosarcoma is only 4 months, and almost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fcf552212c10dacd51588a5362410f5
https://doi.org/10.18632/oncoscience.472

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Abstract 671: Development of an exosomal biomarker signature to detect minimal residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning

Autor: Hirotaka Tomiyasu, Ali Khammanivong, Brad A. Bryan, Alexa N. Montoya, Joelle M. Fenger, William C. Kisseberth, Kristi Ward, Jaime F. Modiano, Alicia J. Donnelly, Dana C. Galvan, Kelly M. Makielski, John R. Garbe, Subbaya Subramanian, Andrea Ortiz, Milcah C. Scott, Gary Cutter, Lauren J. Mills

Publikováno v: Cancer Research. 81:671-671

Osteosarcoma, the most common primary bone tumor in humans and dogs, has a guarded prognosis. A major hurdle in developing more effective osteosarcoma therapies is the lack of disease-specific biomarkers to predict risk, prognosis, or therapeutic res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b23ca1513199624837357313734613a8
https://doi.org/10.1158/1538-7445.am2021-671

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PD-1 and PD-L1 expression in bone and soft tissue sarcomas

Autor: Alireza Torabi, Brad A. Bryan, Clarissa N. Amaya, Frank H. Wians

Publikováno v: Pathology. 49:506-513

PD-1 and its ligands have been shown to play a significant role in evasion of malignant tumour cells from the immune system. Last year, the Unites States Food and Drug Administration (FDA) approved anti-PD-1 inhibitors for treatment of non-small cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a99128d842e0fd10d4f34f05e8b960
https://doi.org/10.1016/j.pathol.2017.05.003

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Enhanced expression of Programmed cell death 1 (PD-1) protein in benign vascular anomalies

Autor: Clarissa N. Amaya, Alireza Torabi, Frank H. Wians, Brad A. Bryan

Publikováno v: Pathology. 49:292-296

Programmed cell death 1 (PD-1) and its ligands have been shown to play a significant role in evasion of malignant tumour cells from the immune system. Last year, the United States Food and Drug Administration (FDA) approved anti-PD-1 inhibitors for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8929858f09d99212b3b2e777cefef7ec
https://doi.org/10.1016/j.pathol.2016.10.015

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