An accelerated, clinical-grade protocol to generate high yields of type 1-polarizing messenger RNA–loaded dendritic cells for cancer vaccination

Autor: BRABANTS, E., HEYNS, K., SMET, S. DE, DEVREKER, P., INGELS, J., CABOOTER, N. DE, DEBACKER, V., DULLAERS, M., VAN MEERBEECK, J.P., VANDEKERCKHOVE, B., VERMAELEN, K.Y.

Publikováno v: In Cytotherapy September 2018 20(9):1164-1181

The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome.

Autor: Pyfferoen L; Tumor Immunology Laboratory, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium; VIB Inflammation Research Center, Ghent, Belgium., Brabants E; Tumor Immunology Laboratory, Department of Respiratory Medicine, Ghent University Hospital , Ghent, Belgium., Everaert C; Center for Medical Genetics, Ghent University , Ghent, Belgium., De Cabooter N; Tumor Immunology Laboratory, Department of Respiratory Medicine, Ghent University Hospital , Ghent, Belgium., Heyns K; Tumor Immunology Laboratory, Department of Respiratory Medicine, Ghent University Hospital , Ghent, Belgium., Deswarte K; VIB Inflammation Research Center , Ghent, Belgium., Vanheerswynghels M; VIB Inflammation Research Center , Ghent, Belgium., De Prijck S; VIB Inflammation Research Center , Ghent, Belgium., Waegemans G; Laboratory of Experimental Cancer Research, Ghent University , Ghent, Belgium., Dullaers M; Tumor Immunology Laboratory, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium; VIB Inflammation Research Center, Ghent, Belgium., Hammad H; VIB Inflammation Research Center , Ghent, Belgium., De Wever O; Laboratory of Experimental Cancer Research, Ghent University , Ghent, Belgium., Mestdagh P; Center for Medical Genetics, Ghent University , Ghent, Belgium., Vandesompele J; Center for Medical Genetics, Ghent University , Ghent, Belgium., Lambrecht BN; VIB Inflammation Research Center, Ghent, Belgium; Department of Pulmonary Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands., Vermaelen KY; Tumor Immunology Laboratory, Department of Respiratory Medicine, Ghent University Hospital , Ghent, Belgium.

Publikováno v: Oncoimmunology [Oncoimmunology] 2016 Nov 08; Vol. 6 (1), pp. e1253655. Date of Electronic Publication: 2016 Nov 08 (Print Publication: 2017).