Differentiation of Human Pluripotent Stem Cells into Insulin-Producing Islet Clusters.

Autor: Zhao J; Department of Cellular & Physiological Sciences, Life Science Institute, University of British Columbia; jia.zhao@ubc.ca., Liang S; Department of Cellular & Physiological Sciences, Life Science Institute, University of British Columbia., Braam MJS; Department of Cellular & Physiological Sciences, Life Science Institute, University of British Columbia., Baker RK; Department of Cellular & Physiological Sciences, Life Science Institute, University of British Columbia., Iworima DG; Department of Cellular & Physiological Sciences, Life Science Institute, University of British Columbia; School of Biomedical Engineering, University of British Columbia., Quiskamp N; STEMCELL Technologies Inc., Kieffer TJ; Department of Cellular & Physiological Sciences, Life Science Institute, University of British Columbia; School of Biomedical Engineering, University of British Columbia; Department of Surgery, University of British Columbia; tim.kieffer@ubc.ca.

Publikováno v: Journal of visualized experiments : JoVE [J Vis Exp] 2023 Jun 23 (196). Date of Electronic Publication: 2023 Jun 23.

A Century-long Journey From the Discovery of Insulin to the Implantation of Stem Cell-derived Islets.

Autor: Ramzy A; Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Belmonte PJ; Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Braam MJS; Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Ida S; Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Wilts EM; Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Levings MK; BC Children's Hospital Research Institute (BCCHRI), Vancouver, BC V5Z 4H4, Canada.; Department of Surgery, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.; School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Rezania A; CRISPR Therapeutics, Boston, Massachusetts 02139, USA., Kieffer TJ; Laboratory of Molecular and Cellular Medicine, Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.; Department of Surgery, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.; School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

Publikováno v: Endocrine reviews [Endocr Rev] 2023 Mar 04; Vol. 44 (2), pp. 222-253.

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.

Autor: Oudhoff MJ; The Biomedical Research Centre, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: menno.oudhoff@ntnu.no., Braam MJS; The Biomedical Research Centre, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Freeman SA; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Wong D; The Biomedical Research Centre, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Rattray DG; The Biomedical Research Centre, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Wang J; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Antignano F; The Biomedical Research Centre, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Snyder K; The Biomedical Research Centre, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Refaeli I; The Biomedical Research Centre, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Hughes MR; The Biomedical Research Centre, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., McNagny KM; The Biomedical Research Centre, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Gold MR; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Arrowsmith CH; The Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada; Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Sato T; Department of Gastroenterology, School of Medicine, Keio University, Tokyo 160-8582, Japan., Rossi FMV; The Biomedical Research Centre, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Tatlock JH; Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, San Diego, CA 92121, USA., Owen DR; Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA., Brown PJ; The Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada., Zaph C; The Biomedical Research Centre, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Infection and Immunity Program, Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia. Electronic address: colby.zaph@monash.edu.

Publikováno v: Developmental cell [Dev Cell] 2016 Apr 04; Vol. 37 (1), pp. 47-57.