Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Brückner, David B"'
Autor:
Brandstätter, Tom, Brieger, Emily, Brückner, David B., Ladurner, Georg, Rädler, Joachim, Broedersz, Chase P.
The migration behavior of colliding cells is critically determined by transient contact-interactions. During these interactions, the motility machinery, including the front-rear polarization of the cell, dynamically responds to surface protein-mediat
Externí odkaz:
http://arxiv.org/abs/2407.17268
Autor:
Brückner, David B., Tkačik, Gašper
A key feature of many developmental systems is their ability to self-organize spatial patterns of functionally distinct cell fates. To ensure proper biological function, such patterns must be established reproducibly, by controlling and even harnessi
Externí odkaz:
http://arxiv.org/abs/2312.05895
Single and collective cell migration are fundamental processes critical for physiological phenomena ranging from embryonic development and immune response to wound healing and cancer metastasis. To understand cell migration from a physical perspectiv
Externí odkaz:
http://arxiv.org/abs/2309.00545
Autor:
Nabeel, Arshed, Karichannavar, Ashwin, Palathingal, Shuaib, Jhawar, Jitesh, Brückner, David B., M., Danny Raj, Guttal, Vishwesha
Theoretical studies have shown that stochasticity can affect the dynamics of ecosystems in counter-intuitive ways. However, without knowing the equations governing the dynamics of populations or ecosystems, it is difficult to ascertain the role of st
Externí odkaz:
http://arxiv.org/abs/2205.02645
Autor:
Brandstätter, Tom, Brückner, David B., Han, Yu Long, Alert, Ricard, Guo, Ming, Broedersz, Chase P.
The multicellular organization of diverse systems, such as embryos, intestines and tumours, relies on the coordinated migration of cells in 3D curved environments. In these settings, cells establish supracellular patterns of motion, including collect
Externí odkaz:
http://arxiv.org/abs/2110.14614
Autor:
Brückner, David B., Schmitt, Matthew, Fink, Alexandra, Ladurner, Georg, Flommersfeld, Johannes, Arlt, Nicolas, Hannezo, Edouard, Rädler, Joachim O., Broedersz, Chase P.
Cell migration in confining physiological environments relies on the concerted dynamics of several cellular components, including protrusions, adhesions with the environment, and the cell nucleus. However, it remains poorly understood how the dynamic
Externí odkaz:
http://arxiv.org/abs/2106.01014
Autor:
Brückner, David B., Arlt, Nicolas, Fink, Alexandra, Ronceray, Pierre, Rädler, Joachim O., Broedersz, Chase P.
Publikováno v:
Proc. Natl. Acad. Sci. USA 118 (2021) e2016602118
The migratory dynamics of cells in physiological processes, ranging from wound healing to cancer metastasis, rely on contact-mediated cell-cell interactions. These interactions play a key role in shaping the stochastic trajectories of migrating cells
Externí odkaz:
http://arxiv.org/abs/2008.03978
Publikováno v:
Phys. Rev. Lett. 125, 058103 (2020)
Many complex systems, ranging from migrating cells to animal groups, exhibit stochastic dynamics described by the underdamped Langevin equation. Inferring such an equation of motion from experimental data can provide profound insight into the physica
Externí odkaz:
http://arxiv.org/abs/2002.06680
Publikováno v:
J. R. Soc. Interface 17 (2020) 20190689
Cell-to-cell variability is inherent to numerous biological processes, including cell migration. Quantifying and characterizing the variability of migrating cells is challenging, as it requires monitoring many cells for long time windows under identi
Externí odkaz:
http://arxiv.org/abs/1910.02815
Autor:
Goychuk, Andriy, Brückner, David B., Holle, Andrew W., Spatz, Joachim P., Broedersz, Chase P., Frey, Erwin
Recent experiments suggest that the interplay between cells and the mechanics of their substrate gives rise to a diversity of morphological and migrational behaviors. Here, we develop a Cellular Potts Model of polarizing cells on a visco-elastic subs
Externí odkaz:
http://arxiv.org/abs/1808.00314