Benchmarking whole exome sequencing in the German network for personalized medicine.

Autor: Menzel M; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany; Centers for Personalized Medicine (ZPM), Germany. Electronic address: michael.menzel@med.uni-heidelberg.de., Martis-Thiele M; Institute of Pathology, TUM School of Medicine and Health, Technical University of Munich, Germany., Goldschmid H; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany; Centers for Personalized Medicine (ZPM), Germany., Ott A; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany., Romanovsky E; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany; Centers for Personalized Medicine (ZPM), Germany., Siemanowski-Hrach J; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Seillier L; Institute of Pathology, University Hospital RWTH Aachen, Aachen, Germany; Joint Research Center Computational Biomedicine, University Hospital RWTH Aachen, Aachen, Germany; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Germany., Brüchle NO; Institute of Pathology, University Hospital RWTH Aachen, Aachen, Germany; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Germany., Maurer A; Institute of Pathology, University Hospital RWTH Aachen, Aachen, Germany., Lehmann KV; Joint Research Center Computational Biomedicine, University Hospital RWTH Aachen, Aachen, Germany; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Germany; Cancer Research Center Cologne-Essen, University Hospital Cologne, Germany; Machine Learning in Cancer Genetis and Precision Medicine, University RWTH Aachen, Aachen, Germany., Begemann M; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Germany; Institute for Human Genetics and Genomic Medicine., University Hospital RWTH Aachen, Aachen, Germany; NGS diagnostic centre, University Hospital RWTH Aachen, Aachen, Germany., Elbracht M; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Germany; Institute for Human Genetics and Genomic Medicine., University Hospital RWTH Aachen, Aachen, Germany., Meyer R; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Germany., Dintner S; Pathology, Faculty of Medicine, University of Augsburg, Germany., Claus R; Pathology, Faculty of Medicine, University of Augsburg, Germany; Comprehensive Cancer Center, Faculty of Medicine, University of Augsburg, Germany., Meier-Kolthoff JP; Chair of Biomedical Informatics, Data Mining and Data Analytics, Faculty of Applied Computer Science, University of Augsburg, Germany., Blanc E; Core Unit Bioinformatics, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, Berlin, Germany., Möbs M; Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, Berlin, Germany., Joosten M; Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, Berlin, Germany., Benary M; Core Unit Bioinformatics, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, Berlin, Germany; Charité Comprehensive Cancer Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, Berlin, Germany., Basitta P; Universitätsklinikum Bonn, Molekularpathologische Diagnostik, Institut für Pathologie, Venusberg Campus 1, 53127 Bonn, Germany., Hölscher F; Universitätsklinikum Bonn, Molekularpathologische Diagnostik, Institut für Pathologie, Venusberg Campus 1, 53127 Bonn, Germany., Tischler V; Universitätsklinikum Bonn, Molekularpathologische Diagnostik, Institut für Pathologie, Venusberg Campus 1, 53127 Bonn, Germany., Groß T; Core Unit for Molecular Tumor Diagnostics (CMTD), National Center for Tumor Diseases Dresden (NCT), NCT/UCC Dresden, a partnership between German Cancer Research Center (DKFZ), Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany., Kutz O; Institute for Clinical Genetics, University Hospital Carl Gustav Carus at TUD Dresden University of Technology and Faculty of Medicine of TUD Dresden University of Technology, Dresden, Germany; ERN GENTURIS, Hereditary Cancer Syndrome Center Dresden, Germany; National Center for Tumor Diseases (NCT), NCT/UCC Dresden, a partnership between German Cancer Research Center (DKFZ), Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany; German Cancer Consortium (DKTK), Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., Prause R; Core Unit for Molecular Tumor Diagnostics (CMTD), National Center for Tumor Diseases Dresden (NCT), NCT/UCC Dresden, a partnership between German Cancer Research Center (DKFZ), Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany., William D; Core Unit for Molecular Tumor Diagnostics (CMTD), National Center for Tumor Diseases Dresden (NCT), NCT/UCC Dresden, a partnership between German Cancer Research Center (DKFZ), Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany; Institute for Clinical Genetics, University Hospital Carl Gustav Carus at TUD Dresden University of Technology and Faculty of Medicine of TUD Dresden University of Technology, Dresden, Germany; ERN GENTURIS, Hereditary Cancer Syndrome Center Dresden, Germany; National Center for Tumor Diseases (NCT), NCT/UCC Dresden, a partnership between German Cancer Research Center (DKFZ), Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany; German Cancer Consortium (DKTK), Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., Horny K; Center for Personalized Medicine Oncology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Germany; Core Unit Bioinformatics, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Germany., Goering W; Institute of Pathology, University Hospital Duesseldorf., Sivalingam S; Institute of Human Genetics, Medical Faculty, University Hospital of Düsseldorf, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany., Borkhardt A; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Germany; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, HHU Düsseldorf, Germany; German Cancer Consortium (DKTK), partner site Essen-Düsseldorf, Germany., Blank C; Institute of Human Genetics, Medical Faculty, University Hospital of Düsseldorf, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany., Junk SV; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Germany; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, HHU Düsseldorf, Germany., Yasin L; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Germany; Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, HHU Düsseldorf, Germany., Moskalev EA; Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany; Center for Personalized Medicine (ZPM), Erlangen, Germany; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany; Bavarian Cancer Research Center (BZKF), Erlangen, Germany., Carta MG; Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany; Center for Personalized Medicine (ZPM), Erlangen, Germany; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany; Bavarian Cancer Research Center (BZKF), Erlangen, Germany., Ferrazzi F; Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany; Center for Personalized Medicine (ZPM), Erlangen, Germany; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany; Bavarian Cancer Research Center (BZKF), Erlangen, Germany; Department of Nephropathology, Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany., Tögel L; Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany; Center for Personalized Medicine (ZPM), Erlangen, Germany; Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Germany; Bavarian Cancer Research Center (BZKF), Erlangen, Germany., Wolter S; Institute for Surgical Pathology, Medical Center, University of Freiburg, Germany; Center for Personalized Medicine (ZPM), partner site Freiburg, Germany; Comprehensive Cancer Center Freiburg (CCCF), Medical Center, Freiburg, Germany., Adam E; Institute for Surgical Pathology, Medical Center, University of Freiburg, Germany; Center for Personalized Medicine (ZPM), partner site Freiburg, Germany; Comprehensive Cancer Center Freiburg (CCCF), Medical Center, Freiburg, Germany., Matysiak U; Institute for Surgical Pathology, Medical Center, University of Freiburg, Germany; Center for Personalized Medicine (ZPM), partner site Freiburg, Germany; Comprehensive Cancer Center Freiburg (CCCF), Medical Center, Freiburg, Germany., Rosenthal T; Institut für Pathologie, Universitätsmedizin Göttingen, Germany., Dönitz J; Institut für Bioinformatik, Universitätsmedizin Göttingen, Germany., Lehmann U; Institute of Pathology, Hannover Medical School, Hannover, Germany., Schmidt G; Department of Human Genetics, Hannover Medical School, Hannover, Germany., Bartels S; Institute of Pathology, Hannover Medical School, Hannover, Germany., Hofmann W; Department of Human Genetics, Hannover Medical School, Hannover, Germany., Hirsch S; Institute of Human Genetics, Heidelberg University, Heidelberg, Germany., Dikow N; Institute of Human Genetics, Heidelberg University, Heidelberg, Germany., Göbel K; Department of Neuropathology, University Hospital Heidelberg, Germany., Banan R; Department of Neuropathology, University Hospital Heidelberg, Germany., Hamelmann S; Department of Neuropathology, University Hospital Heidelberg, Germany., Fink A; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany; Centers for Personalized Medicine (ZPM), Germany., Ball M; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany., Neumann O; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany; Centers for Personalized Medicine (ZPM), Germany., Rehker J; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Kloth M; Institut für Pathologie, Universitätsmedizin Mainz, Germany., Murtagh J; Institut für Pathologie, Universitätsmedizin Mainz, Germany., Hartmann N; Institut für Pathologie, Universitätsmedizin Mainz, Germany., Jurmeister P; Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany; German Cancer Consortium, German Cancer Research Center (DKTK/DKFZ), Munich, Partner Site, Munich, Germany., Mock A; Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany; German Cancer Consortium, German Cancer Research Center (DKTK/DKFZ), Munich, Partner Site, Munich, Germany., Kumbrink J; Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany; German Cancer Consortium, German Cancer Research Center (DKTK/DKFZ), Munich, Partner Site, Munich, Germany., Jung A; Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany; German Cancer Consortium, German Cancer Research Center (DKTK/DKFZ), Munich, Partner Site, Munich, Germany., Mayr EM; Institute of Pathology, TUM School of Medicine and Health, Technical University of Munich, Germany., Jacob A; Institute of Pathology, TUM School of Medicine and Health, Technical University of Munich, Germany., Trautmann M; Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany; West German Cancer Center, University Hospital Münster, Münster, Germany., Kirmse S; Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany; West German Cancer Center, University Hospital Münster, Münster, Germany., Falkenberg K; Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany; West German Cancer Center, University Hospital Münster, Münster, Germany., Ruckert C; Centre of Medical Genetics, Department of Medical Genetics, University and University Hospital Münster, Münster, Germany., Hirsch D; Institute of Pathology, University of Regensburg, Germany., Immel A; Institute of Pathology, University of Regensburg, Germany; Centrum für Translationale Onkologie, Universitätsklinikum Regensburg, Germany., Dietmaier W; Institute of Pathology, University of Regensburg, Germany., Haack T; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany., Marienfeld R; Institute of Pathology, University Hospital Ulm, Germany; Centers for Personalized Medicine (ZPM), Ulm, Germany., Fürstberger A; Institute of Pathology, University Hospital Ulm, Germany; Centers for Personalized Medicine (ZPM), Ulm, Germany., Niewöhner J; Institute of Pathology, University Hospital Ulm, Germany; Centers for Personalized Medicine (ZPM), Ulm, Germany., Gerstenmaier U; Institute of Pathology, University Hospital Ulm, Germany; Centers for Personalized Medicine (ZPM), Ulm, Germany., Eberhardt T; Centers for Personalized Medicine (ZPM), Ulm, Germany; Department of Medicine III, University Hospital, LMU Munich, Munich, Germany., Greif PA; German Cancer Consortium, German Cancer Research Center (DKTK/DKFZ), Munich, Partner Site, Munich, Germany; Department of Medicine III, University Hospital, LMU Munich, Munich, Germany; Institute of Human Genetics, University Hospital, LMU Munich, Munich, Germany., Appenzeller S; Comprehensive Cancer Center Mainfranken, University Hospital Wuerzburg, Germany., Maurus K; Institute of Pathology, University of Wuerzburg, Germany., Doll J; Institute of Pathology, University of Wuerzburg, Germany., Jelting Y; Institute of Human Genetics, University of Wuerzburg, Germany., Jonigk D; Institute of Pathology, University Hospital RWTH Aachen, Aachen, Germany; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Germany; Biomedical Research in End-stage and Obstructive Lung Disease Hannover (BREATH), German Lung Research Centre (DZL), Hannover, Germany., Märkl B; Pathology, Faculty of Medicine, University of Augsburg, Germany., Beule D; Core Unit Bioinformatics, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, Berlin, Germany., Horst D; Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, Berlin, Germany., Wulf AL; Universitätsklinikum Bonn, Molekularpathologische Diagnostik, Institut für Pathologie, Venusberg Campus 1, 53127 Bonn, Germany., Aust D; Core Unit for Molecular Tumor Diagnostics (CMTD), National Center for Tumor Diseases Dresden (NCT), NCT/UCC Dresden, a partnership between German Cancer Research Center (DKFZ), Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Germany; Institut für Pathologie, Universitätsklinikum Carl Gustav Carus der TU Dresden, Fetscherstr. 74, 01307 Dresden, Germany., Werner M; Institute for Surgical Pathology, Medical Center, University of Freiburg, Germany; Center for Personalized Medicine (ZPM), partner site Freiburg, Germany; Comprehensive Cancer Center Freiburg (CCCF), Medical Center, Freiburg, Germany; German Cancer Consortium (DKTK), Partner Site Freiburg, Germany., Reuter-Jessen K; Institut für Pathologie, Universitätsmedizin Göttingen, Germany., Ströbel P; Institut für Pathologie, Universitätsmedizin Göttingen, Germany., Auber B; Department of Human Genetics, Hannover Medical School, Hannover, Germany., Sahm F; Department of Neuropathology, University Hospital Heidelberg, Germany; CCU Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Merkelbach-Bruse S; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Siebolts U; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Roth W; Institut für Pathologie, Universitätsmedizin Mainz, Germany., Lassmann S; Institute for Surgical Pathology, Medical Center, University of Freiburg, Freiburg, Germany; Center for Personalized Medicine (ZPM), Freiburg, Germany., Klauschen F; Department of Human Genetics, Hannover Medical School, Hannover, Germany; Institute of Human Genetics, Heidelberg University, Heidelberg, Germany., Gaisa NT; Institute of Pathology, University Hospital RWTH Aachen, Aachen, Germany; Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Germany; Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany., Weichert W; Institute of Pathology, TUM School of Medicine and Health, Technical University of Munich, Germany., Evert M; Institute of Pathology, University of Regensburg, Germany., Armeanu-Ebinger S; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany., Ossowski S; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany., Schroeder C; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany., Schaaf CP; Institute of Human Genetics, Heidelberg University, Heidelberg, Germany., Malek N; Centers for Personalized Medicine (ZPM), Germany; Department of Gastroenterology, Tübingen University Hospital, Tübingen, Germany., Schirmacher P; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany; Centers for Personalized Medicine (ZPM), Germany., Kazdal D; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany., Pfarr N; Institute of Pathology, TUM School of Medicine and Health, Technical University of Munich, Germany., Budczies J; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany; Centers for Personalized Medicine (ZPM), Germany., Stenzinger A; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany; Centers for Personalized Medicine (ZPM), Germany; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany; German Cancer Consortium (DKTK), Germany. Electronic address: albrecht.stenzinger@med.uni-heidelberg.de.

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